| Cormorant Asset Management, LP |
| 1.12% | 1.11% | #2 | $22.0M | 2.3M | $22.0M | 2.3M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.31% | 0.32% | #9 | $16.3M | 1.7M | $16.3M | 1.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $12.5M | 1.3M | $2.6M | 271,636 | +1.1M+390.04% | Add |
| Aberdeen Group plc |
| 0.02% | 0.02% | #18 | $12.4M | 1.3M | $12.4M | 1.3M | 00.00% | Unchanged |
| DIADEMA PARTNERS LP |
| 1.08% | 0.89% | #3 | $8.8M | 935,064 | $5.2M | 555,257 | +379,807+68.40% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $7.1M | 760,940 | $6.9M | 734,106 | +26,834+3.66% | Add |
| Jones Hill Capital LP |
| 1.3% | — | #1 | $6.1M | 653,572 | $0 | 0 | +653,572 | New Buy |
| Prosight Management, LP |
| 1.05% | 1.07% | #5 | $6.1M | 650,000 | $6.5M | 697,108 | -47,108-6.76% | Reduce |
| Caption Management, LLC |
| 0.03% | <0.01% | #16 | $5.6M | 600,152 | $60,753 | 6,470 | +593,682+9,175.92% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #42 | $5.5M | 587,703 | $3.9M | 418,315 | +169,388+40.49% | Add |
| ADAR1 Capital Management, LLC |
| 0.21% | 0.2% | #11 | $4.5M | 481,787 | $3.4M | 366,781 | +115,006+31.36% | Add |
| Stonepine Capital Management, LLC |
| 0.61% | 1.44% | #6 | $4.0M | 425,000 | $3.6M | 383,462 | +41,538+10.83% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #52 | $4.0M | 423,374 | $1.8M | 187,029 | +236,345+126.37% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #66 | $2.4M | 254,672 | $646,708 | 68,872 | +185,800+269.78% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #27 | $2.3M | 240,100 | $67,589 | 7,198 | +232,902+3,235.65% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #49 | $2.1M | 224,754 | $7.6M | 806,560 | -581,806-72.13% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #47 | $1.8M | 190,214 | $1.3M | 136,602 | +53,612+39.25% | Add |
| Exome Asset Management LLC |
| 1.07% | 1.14% | #4 | $1.7M | 184,914 | $2.2M | 234,136 | -49,222-21.02% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #58 | $1.6M | 170,333 | $955,836 | 101,793 | +68,540+67.33% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | <0.01% | #31 | $1.4M | 151,640 | $1.5M | 160,462 | -8,822-5.50% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #57 | $1.2M | 124,906 | $389,723 | 41,504 | +83,402+200.95% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $1.1M | 112,397 | $903,703 | 96,241 | +16,156+16.79% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $1.0M | 111,302 | $228,787 | 24,365 | +86,937+356.81% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #32 | $1.0M | 110,822 | $3.3M | 346,998 | -236,176-68.06% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #38 | $1.0M | 108,200 | $496,130 | 52,836 | +55,364+104.78% | Add |
| DAFNA Capital Management LLC |
| 0.19% | — | #12 | $1.0M | 107,773 | $0 | 0 | +107,773 | New Buy |
| Persistent Asset Partners Ltd |
| 0.29% | 0.42% | #10 | $956,563 | 78,534 | $1.1M | 111,518 | -32,984-29.58% | Reduce |
| Advisory Services Network, LLC |
| 0.01% | <0.01% | #21 | $843,740 | 89,951 | $131 | 14 | +89,937+642,407.14% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #39 | $744,125 | 79,331 | $1.4M | 146,596 | -67,265-45.88% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #46 | $732,766 | 78,120 | $98,492 | 10,489 | +67,631+644.78% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #20 | $712,683 | 75,979 | $0 | 0 | +75,979 | New Buy |
| XTX Topco Ltd |
| 0.01% | 0.01% | #22 | $634,595 | 67,654 | $357,036 | 38,023 | +29,631+77.93% | Add |
| Verdad Advisers, LP |
| 0.57% | 0.53% | #7 | $596,596 | 63,603 | $471,866 | 50,252 | +13,351+26.57% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #74 | $589,655 | 62,863 | $874,313 | 93,111 | -30,248-32.49% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #68 | $520,168 | 55,455 | $0 | 0 | +55,455 | New Buy |
| HSBC HOLDINGS PLC |
| <0.01% | — | #53 | $504,747 | 55,224 | $0 | 0 | +55,224 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #71 | $457,716 | 48,797 | $362,811 | 38,638 | +10,159+26.29% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #67 | $424,746 | 45,282 | $0 | 0 | +45,282 | New Buy |
| Rangeley Capital, LLC |
| 0.39% | 0.41% | #8 | $412,720 | 44,000 | $421,048 | 44,840 | -840-1.87% | Reduce |
| CANTOR FITZGERALD, L. P. |
| <0.01% | 0.01% | #24 | $376,117 | 40,098 | $376,512 | 40,098 | 00.00% | Unchanged |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| <0.01% | — | #29 | $365,604 | 38,977 | $0 | 0 | +38,977 | New Buy |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $350,709 | 37,389 | $1.0M | 108,792 | -71,403-65.63% | Reduce |
| LMR Partners LLP |
| <0.01% | — | #34 | $332,990 | 35,500 | $0 | 0 | +35,500 | New Buy |
| Engineers Gate Manager LP |
| <0.01% | <0.01% | #25 | $279,524 | 29,800 | $133,338 | 14,200 | +15,600+109.86% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #80 | $246,422 | 26,271 | $119,000 | 12,572 | +13,699+108.96% | Add |
| Velan Capital Investment Management LP |
| 0.15% | 0.15% | #13 | $243,880 | 26,000 | $244,140 | 26,000 | 00.00% | Unchanged |
| Jump Financial, LLC |
| <0.01% | <0.01% | #30 | $242,004 | 25,800 | $287,334 | 30,600 | -4,800-15.69% | Reduce |
| Pale Fire Capital SE |
| 0.02% | 0.02% | #19 | $227,943 | 24,301 | $200,477 | 21,350 | +2,951+13.82% | Add |
| Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #23 | $212,419 | 22,646 | $0 | 0 | +22,646 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #64 | $211,116 | 22,507 | $142,155 | 15,139 | +7,368+48.67% | Add |
