| BML Capital Management, LLC |
| 4.07% | 4.24% | #1 | $7.1M | 5.3M | $6.6M | 5.3M | +10,000+0.19% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.26% | 0.27% | #6 | $5.7M | 4.2M | $5.3M | 4.2M | 00.00% | Unchanged |
| Sio Capital Management, LLC |
| 0.58% | 0.55% | #3 | $3.5M | 2.6M | $3.8M | 3.1M | -442,443-14.38% | Reduce |
| Euclidean Capital LLC |
| 0.8% | 0.83% | #2 | $3.5M | 2.6M | $3.3M | 2.6M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #19 | $3.2M | 2.4M | $2.3M | 1.9M | +500,000+26.88% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $3.0M | 2.2M | $2.7M | 2.2M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $2.7M | 2.0M | $2.4M | 2.0M | +37,114+1.88% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.11% | 0.09% | #10 | $2.6M | 2.0M | $3.6M | 2.9M | -913,185-31.79% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #23 | $2.6M | 2.0M | $2.3M | 1.9M | +69,606+3.69% | Add |
| Eversept Partners, LP |
| 0.13% | 0.15% | #7 | $2.5M | 1.9M | $2.9M | 2.3M | -457,456-19.48% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $1.2M | 919,818 | $1.1M | 874,374 | +45,444+5.20% | Add |
| Stonepine Capital Management, LLC |
| 0.11% | 0.35% | #9 | $718,355 | 536,086 | $878,046 | 708,102 | -172,016-24.29% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $634,624 | 473,158 | $615,455 | 495,922 | -22,764-4.59% | Reduce |
| Aldebaran Capital, LLC |
| 0.47% | 0.45% | #4 | $626,359 | 467,432 | $586,969 | 473,362 | -5,930-1.25% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #16 | $574,663 | 428,853 | $531,778 | 428,853 | 00.00% | Unchanged |
| BIT Capital GmbH |
| 0.02% | 0.01% | #12 | $546,124 | 407,555 | $153,208 | 123,555 | +284,000+229.86% | Add |
| Verdad Advisers, LP |
| 0.47% | 0.25% | #5 | $485,564 | 362,361 | $223,400 | 180,161 | +182,200+101.13% | Add |
| Walleye Capital LLC |
| <0.01% | <0.01% | #24 | $449,830 | 335,694 | $416,261 | 335,694 | 00.00% | Unchanged |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #28 | $442,204 | 330,003 | $447,375 | 360,786 | -30,783-8.53% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #32 | $430,956 | 321,610 | $538,276 | 434,093 | -112,483-25.91% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #37 | $341,399 | 254,775 | $369,676 | 298,126 | -43,351-14.54% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #44 | $334,475 | 249,608 | $160,144 | 129,148 | +120,460+93.27% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #47 | $321,747 | 240,110 | $298,258 | 240,531 | -421-0.18% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.01% | 0.02% | #14 | $269,351 | 201,008 | $286,450 | 231,008 | -30,000-12.99% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #55 | $245,459 | 183,178 | $227,141 | 183,178 | 00.00% | Unchanged |
| RBF Capital, LLC |
| 0.01% | 0.01% | #17 | $217,348 | 162,200 | $201,128 | 162,200 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $183,572 | 136,994 | $142,431 | 114,864 | +22,130+19.27% | Add |
| MAI Capital Management |
| <0.01% | — | #26 | $178,383 | 133,122 | $0 | 0 | +133,122 | New Buy |
| EVOKE WEALTH, LLC |
| <0.01% | <0.01% | #22 | $165,071 | 133,122 | $165,071 | 133,122 | 00.00% | Unchanged |
| Rangeley Capital, LLC |
| 0.13% | 0.08% | #8 | $132,982 | 99,240 | $82,889 | 66,846 | +32,394+48.46% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #52 | $124,683 | 93,047 | $143,123 | 115,422 | -22,375-19.39% | Reduce |
| Ikarian Capital, LLC |
| 0.01% | 0.01% | #13 | $119,442 | 89,136 | $110,529 | 89,136 | 00.00% | Unchanged |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #33 | $94,475 | 70,504 | $223,043 | 179,873 | -109,369-60.80% | Reduce |
| PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #41 | $91,038 | 67,938 | $84,682 | 68,292 | -354-0.52% | Reduce |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #25 | $83,174 | 62,070 | $75,856 | 61,174 | +896+1.46% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #57 | $76,122 | 56,807 | $153,777 | 124,014 | -67,207-54.19% | Reduce |
| Seven Fleet Capital Management LP |
| 0.01% | 0.02% | #15 | $71,782 | 53,569 | $78,738 | 63,498 | -9,929-15.64% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #42 | $68,340 | 51,000 | $10,144 | 8,181 | +42,819+523.40% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #35 | $67,683 | 50,510 | $0 | 0 | +50,510 | New Buy |
| Accurate Wealth Management, LLC |
| 0.01% | 0.01% | #18 | $62,000 | 50,000 | $66,500 | 50,000 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $55,856 | 41,684 | $45,353 | 32,395 | +9,289+28.67% | Add |
| ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #27 | $53,403 | 39,853 | $52,000 | 41,590 | -1,737-4.18% | Reduce |
| COOPER/HAIMS ADVISORS, LLC |
| 0.02% | — | #11 | $52,288 | 39,021 | $0 | 0 | +39,021 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #58 | $50,292 | 37,531 | $0 | 0 | +37,531 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #36 | $43,496 | 32,460 | $40,250 | 32,460 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #40 | $42,656 | 31,833 | $33,952 | 27,381 | +4,452+16.26% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #49 | $40,776 | 30,891 | $38,459 | 30,891 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #56 | $37,201 | 27,761 | $34,145 | 27,536 | +225+0.82% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #30 | $36,349 | 27,126 | $33,636 | 27,126 | 00.00% | Unchanged |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #53 | $28,889 | 21,559 | $26,733 | 21,559 | 00.00% | Unchanged |
