| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #23 | $16.8M | 9.0M | $10.1M | 6.3M | +2.8M+44.17% | Add |
| Aberdeen Group plc |
| 0.02% | 0.01% | #24 | $16.6M | 8.9M | $5.4M | 3.3M | +5.6M+169.30% | Add |
| Affinity Asset Advisors, LLC |
| 0.47% | 0.21% | #8 | $10.3M | 5.5M | $4.0M | 2.5M | +3.1M+125.89% | Add |
| Privium Fund Management B.V. |
| 1.89% | 1.84% | #2 | $10.3M | 5.5M | $8.9M | 5.5M | +52,875+0.97% | Add |
| Ikarian Capital, LLC |
| 0.68% | 0.2% | #5 | $6.4M | 3.4M | $2.4M | 1.5M | +1.9M+129.58% | Add |
| Woodline Partners LP |
| 0.02% | — | #26 | $6.1M | 3.3M | $0 | 0 | +3.3M | New Buy |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 1.19% | — | #3 | $5.1M | 2.8M | $0 | 0 | +2.8M | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #50 | $3.3M | 1.8M | $6.2M | 2.9M | -1.1M-39.09% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.43% | — | #9 | $3.3M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Kynam Capital Management, LP |
| 0.16% | 0.16% | #11 | $2.9M | 1.6M | $2.5M | 1.6M | 00.00% | Unchanged |
| DAFNA Capital Management LLC |
| 0.54% | 0.58% | #6 | $2.8M | 1.5M | $2.5M | 1.6M | -37,200-2.37% | Reduce |
| Squadron Capital Management LLC |
| 0.87% | — | #4 | $2.8M | 1.5M | $0 | 0 | +1.5M | New Buy |
| 683 Capital Management, LLC |
| 0.13% | — | #13 | $2.6M | 1.4M | $0 | 0 | +1.4M | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #48 | $2.2M | 1.2M | $1.1M | 703,323 | +480,991+68.39% | Add |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.53% | 0.5% | #7 | $2.2M | 1.2M | $2.0M | 1.2M | -76,086-6.16% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #36 | $2.1M | 1.1M | $1.5M | 918,857 | +219,858+23.93% | Add |
| Eversept Partners, LP |
| 0.1% | — | #15 | $1.9M | 1.0M | $0 | 0 | +1.0M | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | 0.01% | #22 | $1.8M | 948,736 | $575,558 | 355,283 | +593,453+167.04% | Add |
| DIADEMA PARTNERS LP |
| 0.21% | 0.05% | #10 | $1.7M | 926,016 | $291,734 | 180,083 | +745,933+414.22% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #51 | $1.2M | 639,243 | $494,528 | 305,264 | +333,979+109.41% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #35 | $1.2M | 620,000 | $1.0M | 620,000 | 00.00% | Unchanged |
| M28 Capital Management LP |
| 2.37% | 1.81% | #1 | $1.1M | 599,793 | $971,665 | 599,793 | 00.00% | Unchanged |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #47 | $1.1M | 571,073 | $884,648 | 546,079 | +24,994+4.58% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #54 | $846,493 | 455,104 | $53,929 | 33,289 | +421,815+1,267.13% | Add |
| STEMPOINT CAPITAL LP |
| 0.11% | — | #14 | $801,760 | 431,054 | $0 | 0 | +431,054 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #49 | $512,674 | 275,631 | $279,205 | 172,349 | +103,282+59.93% | Add |
| Monaco Asset Management SAM |
| 0.04% | 0.13% | #19 | $454,746 | 244,487 | $678,461 | 418,803 | -174,316-41.62% | Reduce |
| Persistent Asset Partners Ltd |
| 0.14% | 0.03% | #12 | $439,804 | 236,454 | $74,629 | 46,067 | +190,387+413.28% | Add |
| Palo Alto Investors LP |
| 0.05% | 0.05% | #16 | $351,181 | 188,807 | $305,867 | 188,807 | 00.00% | Unchanged |
| Burkehill Global Management, LP |
| 0.01% | — | #28 | $327,812 | 176,243 | $0 | 0 | +176,243 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.01% | #25 | $323,350 | 173,844 | $185,000 | 114,256 | +59,588+52.15% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $299,467 | 161,004 | $314,679 | 194,246 | -33,242-17.11% | Reduce |
| FRANKLIN STREET ADVISORS INC /NC |
| 0.02% | — | #27 | $279,000 | 150,000 | $0 | 0 | +150,000 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #55 | $202,297 | 108,762 | $176,194 | 108,762 | 00.00% | Unchanged |
| OneDigital Investment Advisors LLC |
| <0.01% | <0.01% | #39 | $158,100 | 85,000 | $137,700 | 85,000 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #38 | $157,739 | 84,806 | $19,497 | 12,035 | +72,771+604.66% | Add |
| RFG Advisory, LLC |
| <0.01% | <0.01% | #34 | $119,040 | 64,000 | $30,780 | 19,000 | +45,000+236.84% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #60 | $107,954 | 58,040 | $299,878 | 185,110 | -127,070-68.65% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #62 | $107,874 | 57,997 | $137,552 | 84,909 | -26,912-31.70% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #52 | $94,213 | 50,652 | $1.2M | 755,842 | -705,190-93.30% | Reduce |
| Keating Financial Advisory Services, Inc. |
| 0.01% | 0.01% | #29 | $88,447 | 47,552 | $33,294 | 20,552 | +27,000+131.37% | Add |
| Velan Capital Investment Management LP |
| 0.05% | 0.05% | #17 | $83,700 | 45,000 | $72,900 | 45,000 | 00.00% | Unchanged |
| GUGGENHEIM CAPITAL LLC |
| <0.01% | <0.01% | #44 | $74,314 | 39,954 | $44,783 | 27,644 | +12,310+44.53% | Add |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #46 | $65,548 | 35,241 | $2,106 | 1,300 | +33,941+2,610.85% | Add |
| Axiom Investment Management LLC |
| 0.04% | 0.04% | #18 | $57,660 | 31,000 | $53,460 | 33,000 | -2,000-6.06% | Reduce |
| MOODY LYNN LIEBERSON & WALKER, LLC |
| <0.01% | <0.01% | #32 | $46,500 | 25,000 | $40,500 | 25,000 | 00.00% | Unchanged |
| Vanguard Personalized Indexing Management, LLC |
| <0.01% | <0.01% | #45 | $41,097 | 22,095 | $31,444 | 19,410 | +2,685+13.83% | Add |
| Mariner, LLC |
| <0.01% | <0.01% | #56 | $37,514 | 20,169 | $32,674 | 20,169 | 00.00% | Unchanged |
| Verdad Advisers, LP |
| 0.03% | — | #20 | $35,526 | 19,100 | $0 | 0 | +19,100 | New Buy |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.03% | 0.02% | #21 | $32,550 | 17,500 | $16,200 | 10,000 | +7,500+75.00% | Add |
