| Lynx1 Capital Management LP |
| 3.99% | 2.75% | #2 | $20.3M | 1.5M | $17.4M | 1.5M | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 1.08% | 0.84% | #4 | $17.1M | 1.3M | $14.7M | 1.3M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 0.4% | 0.43% | #6 | $13.3M | 1.0M | $11.4M | 1.0M | 00.00% | Unchanged |
| Atlas Venture Life Science Advisors, LLC |
| 1.44% | 1.63% | #3 | $12.7M | 962,884 | $12.9M | 1.1M | -174,265-15.32% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #15 | $12.5M | 951,783 | $11.8M | 1.0M | -88,271-8.49% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $10.8M | 817,621 | $5.2M | 460,006 | +357,615+77.74% | Add |
| Affinity Asset Advisors, LLC |
| 0.42% | 0.41% | #5 | $9.3M | 706,904 | $8.0M | 706,904 | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.29% | 0.28% | #9 | $8.7M | 660,036 | $7.5M | 660,036 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | <0.01% | #16 | $7.1M | 540,968 | $2.6M | 228,400 | +312,568+136.85% | Add |
| ADAR1 Capital Management, LLC |
| 0.33% | 0.36% | #8 | $7.1M | 540,054 | $6.1M | 540,054 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $6.0M | 454,778 | $3.5M | 310,913 | +143,865+46.27% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.03% | 0.04% | #13 | $5.9M | 450,045 | $5.1M | 450,045 | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 0.13% | 0.13% | #10 | $5.5M | 416,301 | $4.7M | 416,301 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.09% | 0.11% | #11 | $4.6M | 347,718 | $3.9M | 347,718 | 00.00% | Unchanged |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $3.9M | 298,974 | $3.0M | 267,755 | +31,219+11.66% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #51 | $3.9M | 296,870 | $2.0M | 173,643 | +123,227+70.97% | Add |
| 72 Investment Holdings, LLC |
| 7.3% | 6.32% | #1 | $3.6M | 276,831 | $3.1M | 276,831 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $3.1M | 232,587 | $1.6M | 140,341 | +92,246+65.73% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $2.9M | 223,551 | $1.7M | 148,559 | +74,992+50.48% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #25 | $2.3M | 178,071 | $1.9M | 165,472 | +12,599+7.61% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #69 | $1.6M | 124,726 | $704,180 | 68,500 | +56,226+82.08% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $1.6M | 123,790 | $3.0M | 269,114 | -145,324-54.00% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $1.6M | 118,434 | $720,020 | 63,606 | +54,828+86.20% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $1.5M | 116,983 | $572,124 | 50,541 | +66,442+131.46% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #23 | $1.5M | 110,524 | $1.5M | 136,227 | -25,703-18.87% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #54 | $1.4M | 105,453 | $245,372 | 21,676 | +83,777+386.50% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $1.2M | 88,089 | $653,186 | 57,702 | +30,387+52.66% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #47 | $987,195 | 74,901 | $470,244 | 41,541 | +33,360+80.31% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.03% | 0.03% | #14 | $837,747 | 63,562 | $711,519 | 62,855 | +707+1.12% | Add |
| F/m Investments LLC |
| 0.04% | 0.05% | #12 | $837,747 | 63,562 | $711,519 | 62,855 | +707+1.12% | Add |
| Walleye Capital LLC |
| <0.01% | — | #21 | $715,529 | 54,289 | $0 | 0 | +54,289 | New Buy |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #34 | $694,850 | 52,720 | $407,271 | 35,978 | +16,742+46.53% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #80 | $681,498 | 51,707 | $0 | 0 | +51,707 | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #55 | $644,765 | 48,920 | $484,926 | 42,838 | +6,082+14.20% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #17 | $630,254 | 47,819 | $684,543 | 60,472 | -12,653-20.92% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #78 | $623,414 | 47,300 | $2.3M | 204,100 | -156,800-76.83% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #89 | $513,691 | 38,975 | $440,348 | 38,900 | +75+0.19% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #18 | $472,543 | 35,853 | $475,440 | 42,000 | -6,147-14.64% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #48 | $450,927 | 34,213 | $0 | 0 | +34,213 | New Buy |
| Jump Financial, LLC |
| <0.01% | — | #19 | $446,881 | 33,906 | $0 | 0 | +33,906 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #71 | $418,196 | 31,730 | $245,980 | 21,730 | +10,000+46.02% | Add |
| AIHC Capital Management Ltd |
| 0.38% | 0.29% | #7 | $398,893 | 30,265 | $342,600 | 30,265 | 00.00% | Unchanged |
| Mariner, LLC |
| <0.01% | <0.01% | #43 | $367,824 | 27,908 | $292,145 | 25,819 | +2,089+8.09% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #57 | $346,028 | 26,254 | $26,647 | 2,354 | +23,900+1,015.29% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | — | #31 | $337,039 | 25,572 | $0 | 0 | +25,572 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $317,770 | 24,110 | $151,620 | 13,394 | +10,716+80.01% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #92 | $296,563 | 22,501 | $8.0M | 167,494 | -144,993-86.57% | Reduce |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #28 | $280,022 | 21,246 | $144,636 | 12,777 | +8,469+66.28% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #52 | $251,211 | 19,060 | $388,763 | 34,343 | -15,283-44.50% | Reduce |
| GUGGENHEIM CAPITAL LLC |
| <0.01% | <0.01% | #26 | $242,512 | 18,400 | $159,579 | 14,097 | +4,303+30.52% | Add |
