| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #15 | $5.7M | 500,000 | $0 | 0 | +500,000 | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.05% | — | #9 | $5.7M | 500,000 | $0 | 0 | +500,000 | New Buy |
| GREAT POINT PARTNERS LLC |
| 1.07% | — | #1 | $5.7M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Jupiter Topco LLC |
| <0.01% | — | #17 | $5.7M | 500,000 | $0 | 0 | +500,000 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.22% | — | #4 | $4.7M | 417,724 | $0 | 0 | +417,724 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #19 | $4.5M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Atika Capital Management LLC |
| 0.44% | — | #2 | $4.5M | 400,000 | $0 | 0 | +400,000 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #23 | $3.6M | 319,986 | $0 | 0 | +319,986 | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.02% | — | #12 | $3.4M | 300,000 | $0 | 0 | +300,000 | New Buy |
| BRAIDWELL LP |
| 0.11% | — | #5 | $2.8M | 250,000 | $0 | 0 | +250,000 | New Buy |
| Nantahala Capital Management, LLC |
| 0.09% | — | #7 | $2.6M | 225,000 | $0 | 0 | +225,000 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.1% | — | #6 | $2.3M | 200,000 | $0 | 0 | +200,000 | New Buy |
| TCG Crossover Management, LLC |
| 0.05% | — | #8 | $2.3M | 200,000 | $0 | 0 | +200,000 | New Buy |
| Spruce Street Capital LP |
| 0.36% | — | #3 | $1.8M | 160,000 | $0 | 0 | +160,000 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #22 | $1.8M | 159,683 | $0 | 0 | +159,683 | New Buy |
| Logos Global Management LP |
| 0.05% | — | #10 | $1.1M | 100,000 | $0 | 0 | +100,000 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #20 | $1.1M | 96,165 | $0 | 0 | +96,165 | New Buy |
| TORONTO DOMINION BANK |
| <0.01% | — | #21 | $573,680 | 50,500 | $0 | 0 | +50,500 | New Buy |
| Woodline Partners LP |
| <0.01% | — | #18 | $568,000 | 50,000 | $0 | 0 | +50,000 | New Buy |
| Magnetar Financial LLC |
| <0.01% | — | #16 | $544,235 | 47,908 | $0 | 0 | +47,908 | New Buy |
| 683 Capital Management, LLC |
| 0.02% | — | #11 | $480,119 | 42,264 | $0 | 0 | +42,264 | New Buy |
| DIADEMA PARTNERS LP |
| 0.01% | — | #13 | $102,479 | 9,021 | $0 | 0 | +9,021 | New Buy |
| Clear Street Group Inc. |
| <0.01% | — | #24 | $80,917 | 7,123 | $0 | 0 | +7,123 | New Buy |
| Persistent Asset Partners Ltd |
| 0.01% | — | #14 | $26,128 | 2,300 | $0 | 0 | +2,300 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #25 | $91 | 8 | $0 | 0 | +8 | New Buy |
