| BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $18.1M | 5.2M | $21.5M | 5.6M | -396,318-7.12% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #22 | $15.6M | 4.4M | $13.2M | 3.4M | +1.0M+29.59% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.15% | 0.24% | #5 | $12.0M | 3.4M | $13.5M | 3.5M | -64,000-1.83% | Reduce |
| Vestal Point Capital, LP |
| 0.21% | 0.32% | #3 | $9.2M | 2.6M | $11.6M | 3.0M | -377,936-12.59% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $8.2M | 2.3M | $8.8M | 2.3M | +62,421+2.73% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #62 | $4.7M | 1.3M | $4.1M | 1.0M | +280,514+26.72% | Add |
| Opaleye Management Inc. |
| 0.38% | 0.58% | #1 | $4.1M | 1.2M | $4.4M | 1.2M | +35,000+3.04% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #76 | $3.8M | 1.1M | $3.7M | 948,226 | +128,196+13.52% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #29 | $3.3M | 948,517 | $2.4M | 615,660 | +332,857+54.07% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #58 | $3.1M | 890,467 | $1.6M | 402,764 | +487,703+121.09% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #45 | $2.9M | 838,184 | $3.4M | 875,568 | -37,384-4.27% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $2.8M | 810,091 | $2.8M | 725,769 | +84,322+11.62% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #73 | $2.4M | 697,334 | $2.8M | 599,688 | +97,646+16.28% | Add |
| Erste Asset Management GmbH |
| 0.02% | 0.04% | #15 | $2.3M | 638,900 | $4.2M | 1.1M | -456,241-41.66% | Reduce |
| DIADEMA PARTNERS LP |
| 0.24% | 0.38% | #2 | $2.0M | 563,642 | $2.2M | 573,642 | -10,000-1.74% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $1.7M | 495,236 | $2.2M | 578,024 | -82,788-14.32% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $1.5M | 428,670 | $957,000 | 248,871 | +179,799+72.25% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.2% | 0.29% | #4 | $1.5M | 427,554 | $1.8M | 469,761 | -42,207-8.98% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #70 | $1.4M | 411,803 | $1.5M | 384,843 | +26,960+7.01% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #50 | $1.2M | 356,109 | $898,149 | 232,681 | +123,428+53.05% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #78 | $1.2M | 338,477 | $1.7M | 427,597 | -89,120-20.84% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #61 | $1.2M | 337,325 | $1.2M | 298,322 | +39,003+13.07% | Add |
| FIDUCIARY TRUST CO |
| 0.01% | 0.02% | #17 | $1.2M | 334,397 | $1.3M | 334,397 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #98 | $988,836 | 276,211 | $1.1M | 276,867 | -656-0.24% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #37 | $826,291 | 236,083 | $1.0M | 268,223 | -32,140-11.98% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | — | #28 | $808,770 | 231,077 | $0 | 0 | +231,077 | New Buy |
| Seven Fleet Capital Management LP |
| 0.13% | 0.14% | #6 | $771,860 | 230,406 | $444,684 | 115,203 | +115,203+100.00% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #95 | $743,222 | 212,349 | $459,999 | 119,171 | +93,178+78.19% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #39 | $679,172 | 194,049 | $67,569 | 17,505 | +176,544+1,008.53% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #104 | $618,097 | 176,599 | $441,163 | 114,291 | +62,308+54.52% | Add |
| FMR LLC |
| <0.01% | <0.01% | #110 | $615,537 | 175,868 | $631,814 | 163,682 | +12,186+7.44% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #99 | $544,341 | 155,526 | $452,000 | 117,078 | +38,448+32.84% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $530,079 | 151,451 | $482,936 | 125,113 | +26,338+21.05% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #65 | $514,059 | 146,874 | $569,917 | 147,647 | -773-0.52% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #84 | $512,946 | 146,556 | $539,510 | 139,770 | +6,786+4.86% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #63 | $503,973 | 143,992 | $381,044 | 98,716 | +45,276+45.86% | Add |
| Altshuler Shaham Ltd |
| 0.01% | 0.02% | #21 | $497,700 | 142,200 | $1.1M | 273,925 | -131,725-48.09% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | — | #54 | $487,980 | 139,422 | $0 | 0 | +139,422 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #89 | $437,647 | 125,042 | $392,648 | 101,722 | +23,320+22.93% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | 0.01% | #18 | $431,193 | 123,198 | $346,296 | 89,714 | +33,484+37.32% | Add |
| Privium Fund Management B.V. |
| 0.08% | 0.1% | #11 | $420,000 | 120,000 | $463,200 | 120,000 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #80 | $409,851 | 117,100 | $452,006 | 117,100 | 00.00% | Unchanged |
| Persistent Asset Partners Ltd |
| 0.12% | 0.17% | #7 | $405,681 | 104,922 | $461,906 | 107,473 | -2,551-2.37% | Reduce |
| CAPTRUST FINANCIAL ADVISORS |
| <0.01% | <0.01% | #42 | $391,954 | 111,987 | $404,737 | 104,854 | +7,133+6.80% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #91 | $357,716 | 102,204 | $386,350 | 100,091 | +2,113+2.11% | Add |
| Verition Fund Management LLC |
| <0.01% | — | #48 | $350,000 | 100,000 | $0 | 0 | +100,000 | New Buy |
| Patriot Financial Group Insurance Agency, LLC |
| 0.03% | 0.04% | #13 | $336,175 | 96,050 | $794,126 | 205,732 | -109,682-53.31% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #20 | $306,107 | 87,459 | $337,592 | 87,459 | 00.00% | Unchanged |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #82 | $266,533 | 69,050 | $231,202 | 58,830 | +10,220+17.37% | Add |
| Birchview Capital, LP |
| 0.12% | 0.16% | #8 | $263,015 | 75,147 | $289,183 | 74,918 | +229+0.31% | Add |
