| FMR LLC |
| <0.01% | <0.01% | #16 | $74.5M | 3.7M | $55.0M | 3.8M | -110,592-2.92% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #31 | $12.9M | 638,420 | $8.1M | 556,052 | +82,368+14.81% | Add |
| SECTORAL ASSET MANAGEMENT INC |
| 6.09% | 5.18% | #1 | $8.7M | 430,407 | $6.3M | 430,407 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $8.0M | 392,181 | $6.0M | 413,480 | -21,299-5.15% | Reduce |
| KCM Capital Inc |
| 0.38% | 0.08% | #5 | $6.1M | 300,000 | $508,550 | 35,000 | +265,000+757.14% | Add |
| TimesSquare Capital Management, LLC |
| 0.09% | 0.08% | #7 | $6.0M | 298,219 | $4.7M | 322,764 | -24,545-7.60% | Reduce |
| Roubaix Capital, LLC |
| 1.86% | 1.74% | #3 | $5.2M | 255,288 | $3.7M | 257,121 | -1,833-0.71% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.03% | — | #8 | $5.1M | 253,760 | $0 | 0 | +253,760 | New Buy |
| Parkman Healthcare Partners LLC |
| 0.47% | — | #4 | $4.6M | 226,212 | $0 | 0 | +226,212 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #30 | $4.0M | 199,529 | $2.7M | 183,679 | +15,850+8.63% | Add |
| CM Management, LLC |
| 1.87% | 1.21% | #2 | $2.9M | 145,000 | $1.5M | 100,000 | +45,000+45.00% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #39 | $2.6M | 124,437 | $1.9M | 130,711 | -6,274-4.80% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #41 | $2.4M | 117,265 | $1.4M | 114,827 | +2,438+2.12% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #47 | $2.3M | 114,859 | $1.4M | 93,245 | +21,614+23.18% | Add |
| HighTower Advisors, LLC |
| <0.01% | — | #19 | $2.1M | 102,640 | $0 | 0 | +102,640 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #38 | $1.8M | 86,307 | $0 | 0 | +86,307 | New Buy |
| Walleye Capital LLC |
| 0.01% | 0.01% | #11 | $1.7M | 86,155 | $1.2M | 85,183 | +972+1.14% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.01% | — | #13 | $1.6M | 77,737 | $0 | 0 | +77,737 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #37 | $1.4M | 71,291 | $930,894 | 64,067 | +7,224+11.28% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $1.4M | 70,335 | $886,286 | 60,997 | +9,338+15.31% | Add |
| Informed Momentum Co LLC |
| 0.1% | — | #6 | $1.2M | 57,998 | $0 | 0 | +57,998 | New Buy |
| KING LUTHER CAPITAL MANAGEMENT CORP |
| <0.01% | — | #14 | $1.1M | 52,350 | $0 | 0 | +52,350 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #20 | $895,545 | 44,159 | $0 | 0 | +44,159 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #21 | $784,167 | 38,667 | $0 | 0 | +38,667 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #35 | $767,111 | 37,826 | $546,648 | 37,622 | +204+0.54% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #32 | $753,240 | 37,142 | $176,932 | 12,177 | +24,965+205.02% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #44 | $746,202 | 36,795 | $196,504 | 13,524 | +23,271+172.07% | Add |
| SEI INVESTMENTS CO |
| <0.01% | — | #22 | $696,618 | 34,350 | $0 | 0 | +34,350 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #57 | $688,080 | 33,929 | $392,063 | 26,983 | +6,946+25.74% | Add |
| READYSTATE ASSET MANAGEMENT LP |
| 0.03% | 0.03% | #9 | $572,932 | 39,431 | $572,932 | 39,431 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #48 | $518,803 | 25,582 | $333,493 | 22,952 | +2,630+11.46% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #45 | $479,176 | 23,628 | $252,328 | 17,366 | +6,262+36.06% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | — | #25 | $464,818 | 22,920 | $0 | 0 | +22,920 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | — | #40 | $401,036 | 19,775 | $0 | 0 | +19,775 | New Buy |
| ARMSTRONG ADVISORY GROUP, INC |
| 0.02% | — | #10 | $350,642 | 17,290 | $0 | 0 | +17,290 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #55 | $322,000 | 15,901 | $783,000 | 53,860 | -37,959-70.48% | Reduce |
| Blue Trust, Inc. |
| <0.01% | <0.01% | #17 | $318,781 | 15,719 | $228,397 | 15,719 | 00.00% | Unchanged |
| Jump Financial, LLC |
| <0.01% | — | #18 | $274,185 | 13,520 | $0 | 0 | +13,520 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #61 | $227,379 | 11,212 | $73,202 | 5,038 | +6,174+122.55% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #36 | $223,337 | 11,013 | $68,924 | 4,744 | +6,269+132.15% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #43 | $207,343 | 10,224 | $32,663 | 2,248 | +7,976+354.80% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #50 | $195,702 | 9,650 | $135,579 | 9,331 | +319+3.42% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #60 | $179,458 | 8,849 | $55,679 | 3,832 | +5,017+130.92% | Add |
| MetLife Investment Management, LLC |
| <0.01% | <0.01% | #23 | $124,316 | 6,130 | $90,435 | 6,224 | -94-1.51% | Reduce |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | — | #27 | $118,577 | 5,847 | $0 | 0 | +5,847 | New Buy |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #58 | $107,478 | 4,716 | $65,364 | 4,716 | 00.00% | Unchanged |
| China Universal Asset Management Co., Ltd. |
| 0.01% | <0.01% | #12 | $101,400 | 5,000 | $52,308 | 3,600 | +1,400+38.89% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #59 | $98,561 | 4,860 | $7,643 | 526 | +4,334+823.95% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | <0.01% | #42 | $98,196 | 4,842 | $70,732 | 4,868 | -26-0.53% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #51 | $65,767 | 3,243 | $5,928 | 408 | +2,835+694.85% | Add |
