| BVF INC/IL |
| 0.63% | 0.62% | #5 | $24.8M | 6.3M | $19.4M | 6.3M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $20.2M | 5.1M | $13.5M | 4.4M | +741,597+16.92% | Add |
| Defilade Capital Management, L.P. |
| 1.86% | 1.54% | #2 | $13.9M | 3.5M | $11.0M | 3.6M | -38,789-1.09% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $13.5M | 3.4M | $10.1M | 3.3M | +124,089+3.77% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #54 | $9.9M | 2.5M | $1.1M | 370,090 | +2.1M+578.30% | Add |
| Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #22 | $8.3M | 2.1M | $7.6M | 2.5M | -363,695-14.75% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $7.7M | 2.0M | $5.5M | 1.8M | +164,818+9.20% | Add |
| Catalio Capital Management, LP |
| 1.26% | 1.06% | #4 | $6.7M | 1.7M | $5.1M | 1.6M | +55,255+3.37% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #91 | $6.4M | 1.6M | $3.6M | 1.2M | +467,298+40.47% | Add |
| Zimmer Partners, LP |
| 0.14% | 0.14% | #12 | $6.3M | 1.6M | $5.8M | 1.9M | -278,401-14.85% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.61% | 0.87% | #6 | $4.7M | 1.2M | $5.5M | 1.8M | -580,944-32.78% | Reduce |
| AWM Investment Company, Inc. |
| 0.38% | 0.38% | #8 | $4.3M | 1.1M | $3.4M | 1.1M | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #67 | $4.1M | 1.0M | $1.7M | 547,447 | +500,798+91.48% | Add |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.42% | 0.35% | #7 | $4.1M | 1.0M | $3.2M | 1.0M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #49 | $3.9M | 979,712 | $0 | 0 | +979,712 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #84 | $3.5M | 883,097 | $2.7M | 869,544 | +13,553+1.56% | Add |
| ADAR1 Capital Management, LLC |
| 0.12% | 0.18% | #13 | $2.6M | 647,812 | $3.0M | 974,421 | -326,609-33.52% | Reduce |
| 22NW, LP |
| 2.4% | 1.54% | #1 | $2.5M | 636,364 | $2.0M | 636,364 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #80 | $2.4M | 616,399 | $1.7M | 543,842 | +72,557+13.34% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $2.3M | 581,028 | $531,045 | 172,417 | +408,611+236.99% | Add |
| CM Management, LLC |
| 1.44% | 1.67% | #3 | $2.3M | 575,000 | $2.0M | 650,000 | -75,000-11.54% | Reduce |
| Blue Owl Capital Holdings LP |
| 0.32% | 1.18% | #9 | $2.2M | 566,509 | $4.4M | 1.4M | -853,403-60.10% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #93 | $2.2M | 560,432 | $338,643 | 109,949 | +450,483+409.72% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #76 | $2.1M | 538,738 | $204,315 | 67,081 | +471,657+703.12% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #109 | $2.1M | 533,365 | $1.3M | 429,889 | +103,476+24.07% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #71 | $2.1M | 528,963 | $1.6M | 503,764 | +25,199+5.00% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #83 | $2.0M | 510,673 | $138,600 | 45,000 | +465,673+1,034.83% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #107 | $1.9M | 485,092 | $619,423 | 239,159 | +245,933+102.83% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #106 | $1.2M | 314,979 | $150,612 | 48,900 | +266,079+544.13% | Add |
| Triumph Capital Management |
| 0.22% | — | #11 | $1.2M | 303,443 | $0 | 0 | +303,443 | New Buy |
| Brevan Howard Capital Management LP |
| 0.01% | 0.01% | #28 | $1.2M | 304,707 | $679,957 | 228,557 | +76,150+33.32% | Add |
| BIT Capital GmbH |
| 0.03% | 0.02% | #17 | $1.0M | 266,000 | $412,720 | 134,000 | +132,000+98.51% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #101 | $974,772 | 247,404 | $597,588 | 194,022 | +53,382+27.51% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #89 | $823,842 | 209,097 | $234,979 | 76,292 | +132,805+174.07% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #52 | $791,546 | 200,900 | $75,768 | 24,600 | +176,300+716.67% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #104 | $657,690 | 166,927 | $443,976 | 144,148 | +22,779+15.80% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #108 | $440,078 | 111,695 | $230,877 | 74,960 | +36,735+49.01% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | — | #46 | $432,774 | 109,841 | $0 | 0 | +109,841 | New Buy |
| Maven Securities LTD |
| 0.01% | — | #27 | $394,000 | 100,000 | $0 | 0 | +100,000 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #82 | $349,112 | 88,609 | $146,683 | 47,626 | +40,983+86.05% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #87 | $349,072 | 88,597 | $27,104 | 8,800 | +79,797+906.78% | Add |
| Prodigy Asset Management LLC |
| 0.1% | — | #14 | $341,610 | 86,703 | $0 | 0 | +86,703 | New Buy |
| Daytona Street Capital LLC |
| 0.23% | 0.2% | #10 | $313,301 | 81,166 | $253,648 | 81,166 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #112 | $301,973 | 76,643 | $275,198 | 89,350 | -12,707-14.22% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #125 | $295,280 | 74,944 | $112,633 | 36,569 | +38,375+104.94% | Add |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #73 | $286,304 | 72,666 | $220,731 | 71,666 | +1,000+1.40% | Add |
| Susquehanna Portfolio Strategies, LLC |
| <0.01% | <0.01% | #35 | $283,361 | 71,919 | $31,207 | 10,132 | +61,787+609.82% | Add |
| Shay Capital LLC |
| 0.02% | — | #20 | $252,160 | 64,000 | $0 | 0 | +64,000 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #139 | $252,097 | 63,984 | $155,000 | 50,162 | +13,822+27.55% | Add |
| Cambridge Investment Research Advisors, Inc. |
| <0.01% | <0.01% | #66 | $236,183 | 59,945 | $148,000 | 48,202 | +11,743+24.36% | Add |
