| Rosalind Advisors, Inc. |
| 9.84% | 12.31% | #1 | $41.6M | 3.3M | $30.6M | 3.3M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $34.1M | 2.7M | $16.6M | 1.8M | +922,336+51.69% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $15.4M | 1.2M | $12.3M | 1.3M | -108,041-8.13% | Reduce |
| Propel Bio Management, LLC |
| 5.74% | 5.77% | #2 | $11.0M | 871,460 | $9.2M | 979,698 | -108,238-11.05% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #52 | $9.2M | 733,115 | $6.4M | 692,031 | +41,084+5.94% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #72 | $8.6M | 679,280 | $6.2M | 664,428 | +14,852+2.24% | Add |
| ALGERT GLOBAL LLC |
| 0.09% | 0.02% | #13 | $7.3M | 580,708 | $1.4M | 145,733 | +434,975+298.47% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $7.1M | 566,371 | $5.5M | 588,055 | -21,684-3.69% | Reduce |
| Divisadero Street Capital Management, LP |
| 0.14% | 0.19% | #8 | $6.3M | 499,796 | $4.6M | 499,796 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #70 | $5.1M | 407,983 | $2.7M | 253,015 | +154,968+61.25% | Add |
| ExodusPoint Capital Management, LP |
| 0.03% | — | #23 | $4.5M | 359,884 | $0 | 0 | +359,884 | New Buy |
| Caption Management, LLC |
| 0.02% | 0.02% | #24 | $4.1M | 328,200 | $3.0M | 328,200 | 00.00% | Unchanged |
| Private Wealth Advisors, LLC |
| 1.02% | 1.54% | #4 | $4.0M | 315,863 | $5.5M | 591,524 | -275,661-46.60% | Reduce |
| Simplify Asset Management Inc. |
| 0.05% | 0.04% | #17 | $3.3M | 264,770 | $2.4M | 261,126 | +3,644+1.40% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #57 | $3.2M | 252,108 | $2.3M | 251,863 | +245+0.10% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $3.2M | 250,312 | $2.7M | 289,131 | -38,819-13.43% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.13% | 0.12% | #10 | $2.8M | 224,385 | $2.1M | 224,385 | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #38 | $2.8M | 218,963 | $1.8M | 191,630 | +27,333+14.26% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #53 | $2.6M | 210,298 | $0 | 0 | +210,298 | New Buy |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.05% | 0.04% | #18 | $2.6M | 204,143 | $1.9M | 207,923 | -3,780-1.82% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $2.4M | 193,448 | $1.7M | 178,036 | +15,412+8.66% | Add |
| Ikarian Capital, LLC |
| 0.25% | 0.32% | #5 | $2.3M | 185,667 | $4.0M | 431,251 | -245,584-56.95% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $2.3M | 181,903 | $1.9M | 201,824 | -19,921-9.87% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #49 | $2.3M | 181,595 | $963,023 | 103,774 | +77,821+74.99% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $2.2M | 172,993 | $297,850 | 32,096 | +140,897+438.99% | Add |
| CIBC WORLD MARKET INC. |
| <0.01% | <0.01% | #34 | $2.1M | 163,208 | $1.8M | 189,737 | -26,529-13.98% | Reduce |
| Lane Generational LLC |
| 1.65% | 1.52% | #3 | $1.9M | 149,663 | $1.9M | 205,092 | -55,429-27.03% | Reduce |
| HSBC HOLDINGS PLC |
| <0.01% | — | #47 | $1.7M | 135,600 | $0 | 0 | +135,600 | New Buy |
| Man Group plc |
| <0.01% | <0.01% | #35 | $1.6M | 128,495 | $948,546 | 102,214 | +26,281+25.71% | Add |
| Diametric Capital, LP |
| 0.16% | 0.38% | #6 | $1.5M | 122,841 | $1.5M | 156,481 | -33,640-21.50% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #78 | $1.4M | 108,159 | $915,343 | 98,636 | +9,523+9.65% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #71 | $1.4M | 107,950 | $351,239 | 37,849 | +70,101+185.21% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #90 | $1.2M | 96,200 | $716,045 | 77,160 | +19,040+24.68% | Add |
| Capital Advisors Wealth Management, LLC |
| 0.14% | 0.12% | #9 | $1.2M | 93,000 | $863,040 | 93,000 | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.01% | — | #30 | $1.1M | 88,035 | $0 | 0 | +88,035 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.07% | 0.01% | #16 | $1.1M | 85,950 | $149,000 | 16,066 | +69,884+434.98% | Add |
| Jefferies Financial Group Inc. |
| 0.01% | 0.01% | #32 | $1.1M | 83,980 | $779,334 | 83,980 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $1.1M | 83,465 | $729,640 | 78,625 | +4,840+6.16% | Add |
| Stonepine Capital Management, LLC |
| 0.15% | 0.37% | #7 | $1.0M | 100,000 | $928,000 | 100,000 | 00.00% | Unchanged |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #48 | $851,813 | 67,658 | $24,165 | 2,604 | +65,054+2,498.23% | Add |
| FOX RUN MANAGEMENT, L.L.C. |
| 0.13% | — | #11 | $776,526 | 61,678 | $0 | 0 | +61,678 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #102 | $774,587 | 61,524 | $535,725 | 57,729 | +3,795+6.57% | Add |
| Quantbot Technologies LP |
| 0.03% | <0.01% | #22 | $749,860 | 59,560 | $86,313 | 9,301 | +50,259+540.36% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #60 | $728,885 | 57,894 | $0 | 0 | +57,894 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #92 | $726,984 | 57,743 | $1.7M | 180,764 | -123,021-68.06% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #59 | $725,864 | 57,654 | $120,807 | 13,018 | +44,636+342.88% | Add |
| Creative Planning |
| <0.01% | <0.01% | #58 | $609,784 | 48,434 | $367,015 | 39,549 | +8,885+22.47% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #97 | $525,179 | 41,714 | $641,610 | 69,139 | -27,425-39.67% | Reduce |
| Pale Fire Capital SE |
| 0.04% | 0.03% | #20 | $504,670 | 40,085 | $371,989 | 40,085 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #61 | $458,822 | 36,444 | $318,615 | 34,334 | +2,110+6.15% | Add |
