| Lynx1 Capital Management LP |
| 1.55% | 1.28% | #2 | $7.9M | 8.0M | $8.1M | 8.0M | 00.00% | Unchanged |
| BVF INC/IL |
| 0.14% | 0.18% | #5 | $5.5M | 5.6M | $5.6M | 5.6M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.01% | 0.02% | #8 | $2.7M | 2.8M | $2.8M | 2.8M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $2.1M | 2.2M | $2.2M | 2.2M | +4,575+0.21% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #19 | $1.9M | 1.9M | $1.2M | 1.2M | +740,595+61.26% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #15 | $1.3M | 1.3M | $1.4M | 1.4M | -37,984-2.78% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $1.3M | 1.3M | $201,000 | 201,987 | +1.1M+546.50% | Add |
| Deer Management Co. LLC |
| 0.11% | 0.2% | #6 | $1.2M | 1.2M | $1.3M | 1.2M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #24 | $1.1M | 1.2M | $1.5M | 1.5M | -296,674-20.32% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #12 | $1.0M | 1.0M | $816,440 | 808,356 | +241,450+29.87% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #30 | $989,026 | 1.0M | $321,596 | 318,411 | +690,696+216.92% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #40 | $974,860 | 994,654 | $1.9M | 1.8M | -846,298-45.97% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | — | #10 | $756,873 | 772,241 | $0 | 0 | +772,241 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #23 | $673,616 | 687,364 | $239,719 | 237,346 | +450,018+189.60% | Add |
| DC Funds, LP |
| 49.27% | 42.4% | #1 | $617,463 | 630,000 | $630,000 | 630,000 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #36 | $573,401 | 584,811 | $623,340 | 616,952 | -32,141-5.21% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #26 | $537,489 | 548,402 | $322,783 | 319,587 | +228,815+71.60% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.03% | 0.02% | #7 | $537,180 | 548,087 | $383,000 | 378,960 | +169,127+44.63% | Add |
| Kalehua Capital Management LLC |
| 0.32% | — | #3 | $445,824 | 454,876 | $0 | 0 | +454,876 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #32 | $356,675 | 363,954 | $308,830 | 305,772 | +58,182+19.03% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #37 | $236,687 | 241,493 | $145,865 | 144,421 | +97,072+67.21% | Add |
| Verdad Advisers, LP |
| 0.22% | 0.15% | #4 | $228,127 | 232,759 | $135,341 | 134,001 | +98,758+73.70% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #49 | $203,187 | 207,313 | $209,386 | 207,313 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #44 | $193,952 | 197,891 | $1.5M | 847,537 | -649,646-76.65% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #25 | $161,325 | 164,601 | $0 | 0 | +164,601 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #14 | $146,493 | 149,467 | $61,327 | 60,720 | +88,747+146.16% | Add |
| BROWN BROTHERS HARRIMAN & CO |
| <0.01% | <0.01% | #22 | $140,204 | 143,051 | $144,482 | 143,051 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #39 | $136,016 | 138,778 | $98,422 | 97,448 | +41,330+42.41% | Add |
| LETKO, BROSSEAU & ASSOCIATES INC |
| <0.01% | <0.01% | #18 | $93,967 | 95,875 | $96,834 | 95,875 | 00.00% | Unchanged |
| NewEdge Wealth, LLC |
| <0.01% | <0.01% | #21 | $89,643 | 91,463 | $92,378 | 91,463 | 00.00% | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #20 | $75,370 | 76,900 | $113,019 | 111,900 | -35,000-31.28% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $69,111 | 70,514 | $37,640 | 37,267 | +33,247+89.21% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #42 | $68,104 | 69,487 | $53,161 | 52,635 | +16,852+32.02% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #47 | $67,495 | 68,873 | $32,809 | 32,484 | +36,389+112.02% | Add |
| STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #34 | $66,838 | 68,200 | $70,094 | 69,400 | -1,200-1.73% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #43 | $64,028 | 65,335 | $65,815 | 65,335 | 00.00% | Unchanged |
| Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #27 | $61,281 | 62,525 | $63,150 | 62,525 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #53 | $48,118 | 49,100 | $58,104 | 57,529 | -8,429-14.65% | Reduce |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
| <0.01% | <0.01% | #31 | $35,872 | 36,600 | $27,977 | 27,700 | +8,900+32.13% | Add |
| DC Investments Management, LLC |
| 0.01% | 0.01% | #9 | $34,855 | 35,563 | $35,919 | 35,563 | 00.00% | Unchanged |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| <0.01% | — | #16 | $25,349 | 25,864 | $0 | 0 | +25,864 | New Buy |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #45 | $23,842 | 24,574 | $24,439 | 24,574 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #54 | $23,153 | 23,623 | $158,800 | 157,228 | -133,605-84.98% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #52 | $18,788 | 19,170 | $17,251 | 17,080 | +2,090+12.24% | Add |
| R Squared Ltd |
| 0.01% | — | #11 | $17,995 | 18,360 | $0 | 0 | +18,360 | New Buy |
| Vanguard Personalized Indexing Management, LLC |
| <0.01% | <0.01% | #29 | $17,602 | 17,959 | $21,573 | 21,359 | -3,400-15.92% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #55 | $16,089 | 16,458 | $15,456 | 16,436 | +22+0.13% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #48 | $15,391 | 15,705 | $15,862 | 15,705 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #41 | $11,999 | 12,245 | $9,853 | 9,756 | +2,489+25.51% | Add |
| Aries Wealth Management |
| <0.01% | <0.01% | #13 | $9,801 | 10,000 | $10,100 | 10,000 | 00.00% | Unchanged |
