| EQT Fund Management S.a r.l. |
| 7.74% | 5.28% | #2 | $66.7M | 5.1M | $53.9M | 5.1M | 00.00% | Unchanged |
| Sanofi |
| 6.76% | 8.69% | #3 | $36.1M | 2.8M | $29.2M | 2.8M | 00.00% | Unchanged |
| Redmile Group, LLC |
| 2.38% | 0.11% | #4 | $35.5M | 2.7M | $1.6M | 156,250 | +2.6M+1,649.71% | Add |
| Cormorant Asset Management, LP |
| 1.62% | 1.3% | #5 | $32.0M | 2.5M | $25.9M | 2.5M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 0.64% | 0.62% | #8 | $26.7M | 2.1M | $21.5M | 2.1M | 00.00% | Unchanged |
| FEDERATED HERMES, INC. |
| 0.03% | 0.03% | #15 | $21.0M | 1.6M | $17.0M | 1.6M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.68% | 0.47% | #7 | $20.4M | 1.6M | $12.9M | 1.2M | +368,188+30.68% | Add |
| Casdin Capital, LLC |
| 1.01% | 1.23% | #6 | $20.1M | 1.6M | $16.3M | 1.6M | 00.00% | Unchanged |
| Andera Partners |
| 9.67% | 9.12% | #1 | $20.0M | 1.5M | $16.1M | 1.5M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #23 | $18.9M | 1.5M | $15.3M | 1.5M | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.02% | 0.01% | #18 | $11.0M | 846,695 | $7.4M | 707,656 | +139,039+19.65% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.12% | 0.12% | #12 | $7.8M | 600,000 | $6.3M | 600,000 | 00.00% | Unchanged |
| Samsara BioCapital, LLC |
| 0.64% | 0.61% | #9 | $7.8M | 600,000 | $6.3M | 600,000 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.11% | 0.12% | #13 | $5.3M | 411,250 | $4.3M | 411,250 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.05% | — | #14 | $2.5M | 192,740 | $0 | 0 | +192,740 | New Buy |
| PFIZER INC |
| 0.61% | 0.34% | #10 | $1.0M | 75,000 | $813,750 | 75,000 | 00.00% | Unchanged |
| ALPS ADVISORS INC |
| <0.01% | — | #20 | $648,792 | 49,984 | $0 | 0 | +49,984 | New Buy |
| Bellevue Group AG |
| 0.01% | 0.01% | #19 | $639,239 | 49,248 | $524,500 | 50,000 | -752-1.50% | Reduce |
| SEVEN GRAND MANAGERS, LLC |
| 0.02% | 0.14% | #16 | $617,848 | 47,600 | $2.1M | 200,000 | -152,400-76.20% | Reduce |
| SECTORAL ASSET MANAGEMENT INC |
| 0.39% | 0.4% | #11 | $564,630 | 43,500 | $477,295 | 43,500 | 00.00% | Unchanged |
| Burkehill Global Management, LP |
| 0.02% | 0.02% | #17 | $454,300 | 35,000 | $367,150 | 35,000 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | — | #21 | $265,584 | 20,461 | $0 | 0 | +20,461 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $234,575 | 18,072 | $149,388 | 14,241 | +3,831+26.90% | Add |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #25 | $221,634 | 17,075 | $248,000 | 23,726 | -6,651-28.03% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #29 | $153,164 | 11,800 | $374,902 | 35,739 | -23,939-66.98% | Reduce |
| XTX Topco Ltd |
| <0.01% | — | #22 | $133,318 | 10,271 | $0 | 0 | +10,271 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #28 | $123,258 | 9,496 | $0 | 0 | +9,496 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $27,622 | 2,128 | $67,524 | 6,437 | -4,309-66.94% | Reduce |
| GAMMA Investing LLC |
| <0.01% | — | #24 | $17,445 | 1,344 | $0 | 0 | +1,344 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #33 | $15,576 | 1,200 | $0 | 0 | +1,200 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #30 | $9,787 | 754 | $0 | 0 | +754 | New Buy |
| Larson Financial Group LLC |
| <0.01% | — | #26 | $9,060 | 698 | $0 | 0 | +698 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #34 | $26 | 2 | $21 | 2 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #31 | $26 | 2 | $0 | 0 | +2 | New Buy |
