| EQT Fund Management S.a r.l. |
| 11.18% | 15.37% | #1 | $96.4M | 7.0M | $156.9M | 5.9M | +1.1M+17.80% | Add |
| Aberdeen Group plc |
| 0.04% | 0.07% | #15 | $30.0M | 2.2M | $46.5M | 1.7M | +412,863+23.63% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #21 | $28.3M | 2.0M | $24.3M | 913,034 | +1.1M+123.70% | Add |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 6.79% | 15.97% | #2 | $20.9M | 1.5M | $44.7M | 1.7M | -174,033-10.36% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #33 | $14.3M | 1.0M | $4.3M | 161,284 | +870,320+539.62% | Add |
| BRAIDWELL LP |
| 0.43% | — | #8 | $11.6M | 834,183 | $0 | 0 | +834,183 | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 0.17% | 0.26% | #10 | $11.2M | 808,827 | $13.1M | 493,827 | +315,000+63.79% | Add |
| Saturn V Capital Management LP |
| 1.36% | 2.49% | #4 | $9.5M | 684,880 | $13.7M | 516,761 | +168,119+32.53% | Add |
| SR ONE CAPITAL MANAGEMENT, LP |
| 0.86% | 1.86% | #6 | $8.9M | 641,022 | $17.0M | 641,022 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.18% | — | #9 | $8.7M | 625,000 | $0 | 0 | +625,000 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #32 | $8.6M | 619,922 | $0 | 0 | +619,922 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.01% | #34 | $7.5M | 540,056 | $35.8M | 1.3M | -805,672-59.87% | Reduce |
| PFM Health Sciences, LP |
| 0.52% | — | #7 | $6.0M | 436,042 | $0 | 0 | +436,042 | New Buy |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #35 | $6.0M | 434,751 | $0 | 0 | +434,751 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | — | #27 | $5.5M | 398,980 | $0 | 0 | +398,980 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #26 | $5.5M | 394,880 | $0 | 0 | +394,880 | New Buy |
| SYQUANT CAPITAL SAS |
| 1.18% | 0.93% | #5 | $5.2M | 375,000 | $5.9M | 222,867 | +152,133+68.26% | Add |
| Nan Fung Group Holdings Ltd |
| 3.17% | 7.69% | #3 | $4.2M | 300,565 | $9.3M | 350,745 | -50,180-14.31% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #29 | $3.6M | 262,113 | $544,829 | 20,490 | +241,623+1,179.22% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #42 | $3.1M | 225,083 | $112,793 | 6,416 | +218,667+3,408.15% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #30 | $3.1M | 220,403 | $1.5M | 56,127 | +164,276+292.69% | Add |
| Alyeska Investment Group, L.P. |
| 0.01% | 0.02% | #24 | $2.9M | 206,332 | $8.8M | 331,332 | -125,000-37.73% | Reduce |
| Woodline Partners LP |
| 0.01% | 0.02% | #22 | $2.8M | 201,200 | $5.3M | 201,200 | 00.00% | Unchanged |
| Y-Intercept (Hong Kong) Ltd |
| 0.05% | 0.01% | #14 | $2.7M | 192,016 | $776,348 | 29,197 | +162,819+557.66% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #41 | $2.5M | 182,415 | $1.7M | 62,746 | +119,669+190.72% | Add |
| Trexquant Investment LP |
| 0.01% | 0.01% | #19 | $2.1M | 151,228 | $1.2M | 44,238 | +106,990+241.85% | Add |
| Compagnie Lombard Odier SCmA |
| 0.02% | 0.03% | #17 | $1.5M | 105,455 | $2.8M | 105,455 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #43 | $963,993 | 69,502 | $1.8M | 67,753 | +1,749+2.58% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #36 | $909,983 | 65,608 | $0 | 0 | +65,608 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #37 | $854,461 | 61,605 | $384,146 | 14,447 | +47,158+326.42% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #46 | $849,176 | 61,224 | $1.6M | 58,925 | +2,299+3.90% | Add |
| ALPS ADVISORS INC |
| <0.01% | 0.01% | #28 | $804,724 | 58,019 | $1.2M | 46,539 | +11,480+24.67% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #20 | $782,143 | 56,391 | $663,686 | 24,960 | +31,431+125.93% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #44 | $696,704 | 50,231 | $0 | 0 | +50,231 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #47 | $609,975 | 43,978 | $1.9M | 69,764 | -25,786-36.96% | Reduce |
| XTX Topco Ltd |
| 0.01% | 0.01% | #23 | $597,742 | 43,096 | $612,182 | 23,023 | +20,073+87.19% | Add |
| Jump Financial, LLC |
| <0.01% | — | #25 | $551,097 | 39,733 | $0 | 0 | +39,733 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #39 | $430,261 | 31,021 | $768,291 | 28,894 | +2,127+7.36% | Add |
| Virtus Investment Advisers, LLC |
| 0.1% | — | #13 | $409,220 | 29,504 | $0 | 0 | +29,504 | New Buy |
| Persistent Asset Partners Ltd |
| 0.11% | — | #12 | $355,127 | 25,604 | $0 | 0 | +25,604 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #53 | $327,013 | 23,577 | $505,210 | 19,000 | +4,577+24.09% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #50 | $325,234 | 24,846 | $1.3M | 53,045 | -28,199-53.16% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $286,041 | 20,623 | $563,416 | 21,189 | -566-2.67% | Reduce |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. |
| 0.01% | 0.04% | #18 | $239,618 | 17,276 | $503,242 | 18,926 | -1,650-8.72% | Reduce |
| Marble Bar Asset Management LLP |
| 0.14% | — | #11 | $205,359 | 14,806 | $0 | 0 | +14,806 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #52 | $156,148 | 11,258 | $2.4M | 90,161 | -78,903-87.51% | Reduce |
| Quantbot Technologies LP |
| <0.01% | — | #31 | $73,775 | 5,319 | $0 | 0 | +5,319 | New Buy |
| Aventura Private Wealth, LLC |
| 0.02% | 0.04% | #16 | $55,480 | 4,000 | $106,360 | 4,000 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #54 | $44,897 | 3,237 | $0 | 0 | +3,237 | New Buy |
| WOLVERINE ASSET MANAGEMENT LLC |
| <0.01% | — | #40 | $41,263 | 2,975 | $0 | 0 | +2,975 | New Buy |
