| GILEAD SCIENCES, INC. |
| 30.34% | 23.67% | #1 | $500.2M | 16.7M | $501.2M | 16.7M | 00.00% | Unchanged |
| TANG CAPITAL MANAGEMENT LLC |
| 5.16% | 5.77% | #3 | $113.5M | 3.8M | $113.6M | 3.8M | 00.00% | Unchanged |
| Madison Avenue Partners, LP |
| 4.45% | 3.22% | #4 | $103.4M | 3.4M | $74.0M | 2.5M | +982,628+39.86% | Add |
| Prosight Management, LP |
| 10.56% | 7.63% | #2 | $61.3M | 2.0M | $46.5M | 1.6M | +493,344+31.83% | Add |
| EcoR1 Capital, LLC |
| 2.43% | 2.12% | #5 | $50.0M | 1.7M | $50.0M | 1.7M | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #16 | $38.1M | 1.3M | $42.7M | 1.4M | -152,425-10.70% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #26 | $18.0M | 600,986 | $13.9M | 462,687 | +138,299+29.89% | Add |
| DME Capital Management, LP |
| 0.37% | 0.45% | #7 | $14.5M | 482,746 | $14.5M | 482,746 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #12 | $12.2M | 407,800 | $9.5M | 315,400 | +92,400+29.30% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #46 | $10.1M | 338,152 | $9.4M | 312,106 | +26,046+8.35% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #15 | $8.1M | 269,814 | $10.0M | 332,125 | -62,311-18.76% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #22 | $5.9M | 197,844 | $6.5M | 215,718 | -17,874-8.29% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $5.4M | 181,090 | $3.2M | 107,912 | +73,178+67.81% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #34 | $5.0M | 168,148 | $5.3M | 175,289 | -7,141-4.07% | Reduce |
| DAFNA Capital Management LLC |
| 0.74% | 0.89% | #6 | $3.9M | 130,175 | $3.9M | 130,175 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #41 | $2.6M | 88,343 | $4.4M | 146,828 | -58,485-39.83% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #24 | $2.5M | 81,749 | $775,800 | 25,860 | +55,889+216.12% | Add |
| NORGES BANK |
| <0.01% | <0.01% | #42 | $2.3M | 76,879 | $3.0M | 120,000 | -43,121-35.93% | Reduce |
| ALPS ADVISORS INC |
| 0.01% | 0.01% | #14 | $2.0M | 65,523 | $1.6M | 53,661 | +11,862+22.11% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #48 | $1.7M | 56,581 | $1.4M | 45,371 | +11,210+24.71% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #36 | $1.2M | 40,804 | $1.2M | 38,790 | +2,014+5.19% | Add |
| BAROMETER CAPITAL MANAGEMENT INC. |
| 0.34% | 0.39% | #8 | $1.2M | 40,800 | $1.1M | 38,100 | +2,700+7.09% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $1.1M | 37,682 | $2.2M | 64,063 | -26,381-41.18% | Reduce |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #20 | $977,256 | 32,597 | $0 | 0 | +32,597 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #31 | $971,321 | 32,399 | $0 | 0 | +32,399 | New Buy |
| Monaco Asset Management SAM |
| 0.06% | 0.15% | #10 | $767,488 | 25,600 | $825,600 | 27,520 | -1,920-6.98% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $710,556 | 23,701 | $1.4M | 45,942 | -22,241-48.41% | Reduce |
| denkapparat Operations GmbH |
| 0.21% | 0.13% | #9 | $639,294 | 21,324 | $319,080 | 10,636 | +10,688+100.49% | Add |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.04% | #11 | $578,764 | 19,305 | $579,150 | 19,305 | 00.00% | Unchanged |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #33 | $526,958 | 17,577 | $152,460 | 5,082 | +12,495+245.87% | Add |
| QRG CAPITAL MANAGEMENT, INC. |
| <0.01% | 0.01% | #17 | $526,029 | 17,546 | $591,150 | 19,705 | -2,159-10.96% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #29 | $519,493 | 17,328 | $1.4M | 45,168 | -27,840-61.64% | Reduce |
| Erste Asset Management GmbH |
| <0.01% | <0.01% | #21 | $415,380 | 14,000 | $403,760 | 14,000 | 00.00% | Unchanged |
| COMMONWEALTH EQUITY SERVICES, LLC |
| <0.01% | <0.01% | #37 | $343,300 | 11,451 | $314,970 | 10,499 | +952+9.07% | Add |
| Crossmark Global Holdings, Inc. |
| <0.01% | 0.01% | #19 | $315,929 | 10,538 | $978,210 | 32,607 | -22,069-67.68% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $304,297 | 10,150 | $304,500 | 10,150 | 00.00% | Unchanged |
| Cerity Partners LLC |
| <0.01% | <0.01% | #38 | $299,800 | 10,000 | $309,300 | 10,310 | -310-3.01% | Reduce |
| Aquatic Capital Management LLC |
| 0.01% | 0.01% | #13 | $273,088 | 9,109 | $355,770 | 11,859 | -2,750-23.19% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #45 | $249,523 | 8,323 | $216,810 | 7,227 | +1,096+15.17% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #64 | $225,720 | 7,529 | $621,750 | 20,725 | -13,196-63.67% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #44 | $218,755 | 7,297 | $221,430 | 7,381 | -84-1.14% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #50 | $206,742 | 6,896 | $338,760 | 11,292 | -4,396-38.93% | Reduce |
| China Universal Asset Management Co., Ltd. |
| <0.01% | 0.01% | #18 | $71,742 | 2,393 | $78,930 | 2,631 | -238-9.05% | Reduce |
| SIGNATUREFD, LLC |
| <0.01% | <0.01% | #32 | $55,523 | 1,852 | $48,330 | 1,611 | +241+14.96% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #73 | $39,164 | 1,320 | $4,326 | 150 | +1,170+780.00% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #67 | $35,976 | 1,200 | $36,000 | 1,200 | 00.00% | Unchanged |
| Arax Advisory Partners |
| <0.01% | <0.01% | #43 | $30,251 | 1,009 | $26,220 | 874 | +135+15.45% | Add |
| CACTI ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #25 | $30,000 | 1,000 | $30,000 | 1,000 | 00.00% | Unchanged |
| GAMMA Investing LLC |
| <0.01% | <0.01% | #27 | $28,601 | 954 | $60,150 | 2,005 | -1,051-52.42% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #69 | $26,000 | 867 | $20,000 | 661 | +206+31.16% | Add |
