| RA CAPITAL MANAGEMENT, L.P. |
| 0.07% | 0.09% | #8 | $8.1M | 932,624 | $8.1M | 1.2M | -250,000-21.14% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.14% | 0.14% | #7 | $7.3M | 844,787 | $7.0M | 1.0M | -183,157-17.82% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #25 | $5.4M | 626,571 | $4.3M | 626,571 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #29 | $4.0M | 466,248 | $2.6M | 381,823 | +84,425+22.11% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $3.0M | 343,228 | $2.3M | 336,524 | +6,704+1.99% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #20 | $2.4M | 274,375 | $1.9M | 274,375 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #21 | $2.3M | 265,945 | $1.6M | 232,591 | +33,354+14.34% | Add |
| Stonepine Capital Management, LLC |
| 0.32% | 0.61% | #3 | $2.1M | 245,518 | $1.5M | 221,955 | +23,563+10.62% | Add |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #18 | $1.8M | 203,799 | $1.4M | 203,799 | 00.00% | Unchanged |
| Schonfeld Strategic Advisors LLC |
| 0.01% | — | #17 | $1.7M | 195,514 | $0 | 0 | +195,514 | New Buy |
| Carlyle Group Inc. |
| 0.02% | 0.01% | #11 | $1.6M | 184,295 | $1.3M | 184,295 | 00.00% | Unchanged |
| NEXTBio Capital Management LP |
| 0.63% | 0.5% | #1 | $1.4M | 157,827 | $1.1M | 157,827 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #24 | $1.1M | 124,832 | $802,000 | 118,138 | +6,694+5.67% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $836,689 | 96,839 | $293,552 | 43,106 | +53,733+124.65% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $826,703 | 95,634 | $689,043 | 101,135 | -5,501-5.44% | Reduce |
| DAFNA Capital Management LLC |
| 0.15% | 0.15% | #6 | $810,536 | 93,812 | $638,860 | 93,812 | 00.00% | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #13 | $742,686 | 85,959 | $0 | 0 | +85,959 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #28 | $686,775 | 79,488 | $0 | 0 | +79,488 | New Buy |
| Trexquant Investment LP |
| <0.01% | <0.01% | #19 | $673,937 | 78,002 | $297,365 | 43,666 | +34,336+78.63% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #38 | $609,647 | 70,561 | $252,542 | 37,084 | +33,477+90.27% | Add |
| Burkehill Global Management, LP |
| 0.02% | 0.02% | #10 | $540,000 | 62,500 | $425,625 | 62,500 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $536,769 | 62,126 | $249,144 | 36,585 | +25,541+69.81% | Add |
| REGENERON PHARMACEUTICALS, INC. |
| 0.3% | 0.86% | #4 | $522,819 | 60,511 | $412,080 | 60,511 | 00.00% | Unchanged |
| Rangeley Capital, LLC |
| 0.42% | 0.37% | #2 | $439,707 | 50,892 | $381,360 | 56,000 | -5,108-9.12% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #34 | $437,789 | 50,670 | $342,775 | 50,334 | +336+0.67% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #42 | $347,760 | 40,250 | $360,249 | 52,900 | -12,650-23.91% | Reduce |
| RBF Capital, LLC |
| 0.01% | 0.01% | #12 | $333,348 | 38,582 | $262,743 | 38,582 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #46 | $312,958 | 36,222 | $246,672 | 36,222 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | — | #23 | $312,708 | 36,193 | $0 | 0 | +36,193 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #39 | $273,049 | 31,603 | $73,398 | 10,778 | +20,825+193.22% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #41 | $257,619 | 29,817 | $261,286 | 38,368 | -8,551-22.29% | Reduce |
| Verdad Advisers, LP |
| 0.21% | — | #5 | $217,728 | 25,200 | $0 | 0 | +25,200 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #22 | $209,814 | 24,284 | $130,248 | 19,126 | +5,158+26.97% | Add |
| JOHNSON & JOHNSON |
| 0.02% | 0.02% | #9 | $196,811 | 22,779 | $155,125 | 22,779 | 00.00% | Unchanged |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #14 | $160,272 | 18,550 | $0 | 0 | +18,550 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $159,287 | 18,436 | $130,752 | 19,200 | -764-3.98% | Reduce |
| OCCUDO QUANTITATIVE STRATEGIES LP |
| 0.01% | 0.01% | #16 | $143,735 | 16,636 | $114,005 | 15,100 | +1,536+10.17% | Add |
| Squarepoint Ops LLC |
| <0.01% | — | #33 | $131,795 | 15,254 | $0 | 0 | +15,254 | New Buy |
| Vontobel Holding Ltd. |
| <0.01% | <0.01% | #31 | $119,025 | 13,776 | $97,022 | 14,247 | -471-3.31% | Reduce |
| AXQ CAPITAL, LP |
| 0.01% | — | #15 | $94,962 | 10,991 | $0 | 0 | +10,991 | New Buy |
| Jump Financial, LLC |
| <0.01% | — | #26 | $94,539 | 10,942 | $0 | 0 | +10,942 | New Buy |
| Arax Advisory Partners |
| <0.01% | — | #32 | $51,840 | 6,000 | $0 | 0 | +6,000 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #44 | $45,109 | 5,221 | $35,555 | 5,221 | 00.00% | Unchanged |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #43 | $41,592 | 4,814 | $9,486 | 1,393 | +3,421+245.59% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $19,795 | 2,291 | $59,697 | 73,682 | -71,391-96.89% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #50 | $15,000 | 1,701 | $11,000 | 1,687 | +14+0.83% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #49 | $2,592 | 300 | $681 | 100 | +200+200.00% | Add |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #36 | $2,393 | 277 | $9,677 | 1,421 | -1,144-80.51% | Reduce |
| Avion Wealth |
| <0.01% | <0.01% | #30 | $2,125 | 246 | $1,000 | 246 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #54 | $1,677 | 196 | $49 | 8 | +188+2,350.00% | Add |
