| GordonMD Global Investments LP |
| 14.98% | 25.51% | #1 | $37.8M | 4.2M | $36.6M | 4.2M | 00.00% | Unchanged |
| GILEAD SCIENCES, INC. |
| 2.23% | 1.68% | #4 | $36.8M | 4.1M | $35.6M | 4.1M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #65 | $27.9M | 3.1M | $7.6M | 877,078 | +2.3M+257.41% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 1.53% | 2.42% | #6 | $25.7M | 2.9M | $26.8M | 3.1M | -225,000-7.23% | Reduce |
| AIGH Capital Management LLC |
| 1.57% | 2.35% | #5 | $24.9M | 2.8M | $17.3M | 2.0M | +795,797+39.79% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.19% | 0.2% | #12 | $17.8M | 2.0M | $17.3M | 2.0M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $16.9M | 1.9M | $15.4M | 1.8M | +114,109+6.40% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #46 | $10.6M | 1.2M | $13.4M | 1.6M | -369,264-23.74% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $9.4M | 1.0M | $3.7M | 423,826 | +625,604+147.61% | Add |
| Insight Holdings Group, LLC |
| 0.67% | 0.6% | #7 | $8.8M | 989,054 | $8.5M | 989,054 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #62 | $8.8M | 982,307 | $1.0M | 174,203 | +808,104+463.89% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #76 | $8.8M | 982,233 | $1.2M | 138,300 | +843,933+610.22% | Add |
| Propel Bio Management, LLC |
| 4.12% | 3.52% | #3 | $7.9M | 883,198 | $5.6M | 644,421 | +238,777+37.05% | Add |
| Woodline Partners LP |
| 0.02% | 0.03% | #20 | $7.5M | 845,325 | $7.3M | 845,325 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $5.7M | 639,780 | $8.7M | 1.0M | -365,728-36.37% | Reduce |
| MBB PUBLIC MARKETS I LLC |
| 0.59% | 0.63% | #8 | $5.5M | 614,477 | $5.3M | 614,477 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #30 | $4.5M | 500,000 | $4.3M | 500,000 | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #38 | $4.2M | 469,346 | $6.2M | 721,581 | -252,235-34.96% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #57 | $3.3M | 373,009 | $987,263 | 114,399 | +258,610+226.06% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #64 | $3.3M | 365,574 | $3.9M | 449,750 | -84,176-18.72% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $3.0M | 335,230 | $1.8M | 212,910 | +122,320+57.45% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #33 | $3.0M | 333,899 | $3.2M | 367,492 | -33,593-9.14% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #71 | $2.9M | 321,927 | $756,212 | 87,626 | +234,301+267.39% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #67 | $2.8M | 319,666 | $1.8M | 211,088 | +108,578+51.44% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #72 | $2.8M | 315,354 | $673,502 | 78,042 | +237,312+304.08% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #40 | $2.8M | 310,632 | $3.6M | 412,032 | -101,400-24.61% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #93 | $2.5M | 282,189 | $0 | 0 | +282,189 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #85 | $2.4M | 265,405 | $480,933 | 55,728 | +209,677+376.25% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #59 | $2.3M | 259,667 | $1.9M | 224,584 | +35,083+15.62% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #83 | $2.2M | 246,400 | $5.5M | 633,400 | -387,000-61.10% | Reduce |
| Walleye Capital LLC |
| 0.01% | <0.01% | #26 | $2.2M | 245,587 | $329,631 | 38,196 | +207,391+542.97% | Add |
| Y-Intercept (Hong Kong) Ltd |
| 0.04% | 0.02% | #15 | $2.2M | 242,387 | $991,078 | 114,841 | +127,546+111.06% | Add |
| Nuveen, LLC |
| <0.01% | — | #61 | $2.1M | 233,743 | $0 | 0 | +233,743 | New Buy |
| Burkehill Global Management, LP |
| 0.06% | 0.09% | #13 | $1.8M | 200,000 | $1.7M | 200,000 | 00.00% | Unchanged |
| Simplify Asset Management Inc. |
| 0.02% | 0.02% | #21 | $1.6M | 182,603 | $1.5M | 173,106 | +9,497+5.49% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.03% | #19 | $1.3M | 149,900 | $1.3M | 149,900 | 00.00% | Unchanged |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #44 | $1.3M | 145,682 | $1.5M | 169,082 | -23,400-13.84% | Reduce |
| STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #47 | $1.2M | 139,965 | $1.1M | 130,524 | +9,441+7.23% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #49 | $1.1M | 123,646 | $2.9M | 333,692 | -210,046-62.95% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #80 | $1.0M | 117,844 | $1.2M | 136,375 | -18,531-13.59% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #82 | $1.0M | 117,442 | $0 | 0 | +117,442 | New Buy |
| WESBANCO BANK INC |
| 0.02% | 0.03% | #18 | $982,773 | 110,300 | $951,889 | 110,300 | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.01% | 0.01% | #29 | $903,046 | 101,352 | $455,336 | 52,762 | +48,590+92.09% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #86 | $893,504 | 100,281 | $0 | 0 | +100,281 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #106 | $855,813 | 96,051 | $58,782 | 6,811 | +89,240+1,310.23% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | 0.01% | #45 | $855,788 | 96,048 | $9.7M | 1.1M | -1.0M-91.46% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | <0.01% | #23 | $791,609 | 88,845 | $240,311 | 27,846 | +60,999+219.06% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #53 | $738,345 | 82,867 | $1.3M | 146,978 | -64,111-43.62% | Reduce |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #56 | $732,464 | 82,207 | $1.2M | 134,530 | -52,323-38.89% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #90 | $698,713 | 78,419 | $676,756 | 78,419 | 00.00% | Unchanged |
