| RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.18% | #14 | $18.2M | 4.0M | $16.6M | 4.0M | 00.00% | Unchanged |
| BVF INC/IL |
| 0.38% | 0.26% | #9 | $14.8M | 3.2M | $8.2M | 2.0M | +1.3M+63.51% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 3.53% | 3.34% | #2 | $12.9M | 2.8M | $11.8M | 2.8M | 00.00% | Unchanged |
| StepStone Group LP |
| 4.82% | 5.31% | #1 | $11.0M | 2.7M | $11.0M | 2.7M | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.47% | 0.59% | #7 | $10.2M | 2.2M | $10.1M | 2.4M | -196,257-8.06% | Reduce |
| Vivo Capital, LLC |
| 0.8% | 0.66% | #5 | $8.8M | 1.9M | $8.0M | 1.9M | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 0.19% | 0.21% | #10 | $8.3M | 1.8M | $7.6M | 1.8M | -14,120-0.77% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $6.8M | 1.5M | $205,290 | 49,587 | +1.5M+2,924.67% | Add |
| Trails Edge Capital Partners, LP |
| 1.04% | — | #3 | $6.6M | 1.4M | $0 | 0 | +1.4M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $6.6M | 1.4M | $2.4M | 582,477 | +854,562+146.71% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #27 | $5.5M | 1.2M | $5.0M | 1.2M | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #36 | $5.4M | 1.2M | $155,610 | 37,587 | +1.1M+3,058.13% | Add |
| Sio Capital Management, LLC |
| 0.81% | 0.64% | #4 | $4.9M | 1.1M | $4.5M | 1.1M | 00.00% | Unchanged |
| Prosight Management, LP |
| 0.77% | 1.46% | #6 | $4.5M | 978,992 | $8.9M | 2.2M | -1.2M-54.56% | Reduce |
| Logos Global Management LP |
| 0.19% | — | #11 | $4.4M | 963,855 | $0 | 0 | +963,855 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $3.3M | 724,438 | $408,845 | 98,750 | +625,688+633.61% | Add |
| NEA Management Company, LLC |
| 0.14% | 0.11% | #16 | $2.2M | 478,548 | $2.0M | 478,548 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #50 | $2.1M | 463,662 | $55,733 | 13,462 | +450,200+3,344.23% | Add |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #30 | $2.0M | 431,631 | $0 | 0 | +431,631 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #31 | $1.6M | 358,738 | $1.6M | 377,250 | -18,512-4.91% | Reduce |
| Sofinnova Investments, Inc. |
| 0.08% | 0.02% | #21 | $1.5M | 321,692 | $586,638 | 141,700 | +179,992+127.02% | Add |
| Carlyle Group Inc. |
| 0.01% | 0.01% | #25 | $1.2M | 269,895 | $1.1M | 269,895 | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.05% | 0.05% | #22 | $1.1M | 240,963 | $997,587 | 240,963 | 00.00% | Unchanged |
| DV EQUITIES, LLC |
| 0.16% | — | #15 | $1.1M | 240,963 | $0 | 0 | +240,963 | New Buy |
| Seven Fleet Capital Management LP |
| 0.18% | — | #12 | $1.1M | 240,963 | $0 | 0 | +240,963 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $899,127 | 197,177 | $82,398 | 19,903 | +177,274+890.69% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #61 | $810,613 | 177,766 | $0 | 0 | +177,766 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #43 | $753,207 | 165,177 | $179,556 | 43,371 | +121,806+280.85% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #37 | $729,057 | 159,881 | $150,878 | 36,444 | +123,437+338.70% | Add |
| Rosalind Advisors, Inc. |
| 0.16% | 0.74% | #13 | $684,000 | 150,000 | $1.8M | 443,763 | -293,763-66.20% | Reduce |
| Stonepine Capital Management, LLC |
| 0.09% | 0.22% | #19 | $595,919 | 130,684 | $548,873 | 132,578 | -1,894-1.43% | Reduce |
| Longaeva Partners L.P. |
| 0.01% | — | #26 | $549,398 | 120,482 | $0 | 0 | +120,482 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #38 | $496,447 | 108,870 | $100,445 | 24,262 | +84,608+348.73% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #63 | $484,819 | 106,320 | $0 | 0 | +106,320 | New Buy |
| CANTOR FITZGERALD, L. P. |
| <0.01% | 0.01% | #28 | $456,064 | 100,014 | $413,586 | 99,900 | +114+0.11% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #51 | $454,194 | 99,604 | $14,055 | 3,395 | +96,209+2,833.84% | Add |
| Rangeley Capital, LLC |
| 0.41% | 0.38% | #8 | $433,200 | 95,000 | $393,300 | 95,000 | 00.00% | Unchanged |
| Aisling Capital Management LP |
| 0.09% | 0.08% | #20 | $404,048 | 88,607 | $366,833 | 88,607 | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| <0.01% | — | #53 | $329,302 | 72,215 | $0 | 0 | +72,215 | New Buy |
| Walleye Capital LLC |
| <0.01% | — | #32 | $324,230 | 71,103 | $0 | 0 | +71,103 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #52 | $312,453 | 68,563 | $0 | 0 | +68,563 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #59 | $290,198 | 63,640 | $0 | 0 | +63,640 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #29 | $229,336 | 50,293 | $67,453 | 16,293 | +34,000+208.68% | Add |
| Shay Capital LLC |
| 0.01% | 0.05% | #24 | $228,000 | 50,000 | $547,387 | 132,219 | -82,219-62.18% | Reduce |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #23 | $212,916 | 46,692 | $0 | 0 | +46,692 | New Buy |
| Aldebaran Capital, LLC |
| 0.14% | 0.13% | #17 | $181,803 | 39,869 | $167,335 | 40,419 | -550-1.36% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #65 | $166,217 | 36,451 | $55,890 | 13,500 | +22,951+170.01% | Add |
| Nuveen, LLC |
| <0.01% | — | #60 | $161,433 | 35,402 | $0 | 0 | +35,402 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #64 | $144,643 | 31,720 | $103,500 | 25,000 | +6,720+26.88% | Add |
| Verdad Advisers, LP |
| 0.13% | — | #18 | $130,690 | 28,660 | $0 | 0 | +28,660 | New Buy |
