| MONTANOVA CAPITAL, LLC |
| 1.02% | 1.38% | #9 | $55.7M | 9.4M | $53.9M | 9.1M | +376,000+4.15% | Add |
| Venrock Adviser, LLC |
| 1.15% | 1.43% | #6 | $38.0M | 6.4M | $38.3M | 6.4M | 00.00% | Unchanged |
| MPM BioImpact LLC |
| 1.61% | — | #5 | $26.4M | 4.5M | $0 | 0 | +4.5M | New Buy |
| GREAT POINT PARTNERS LLC |
| 4.7% | 5.77% | #1 | $24.9M | 4.2M | $25.1M | 4.2M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #38 | $24.5M | 4.4M | $25.3M | 4.5M | -104,136-2.34% | Reduce |
| BRAIDWELL LP |
| 0.87% | 0.79% | #10 | $23.5M | 4.0M | $23.7M | 4.0M | -8,694-0.22% | Reduce |
| Siren, L.L.C. |
| 0.45% | 0.62% | #14 | $22.0M | 3.7M | $22.2M | 3.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $21.3M | 3.6M | $2.7M | 457,359 | +3.2M+690.34% | Add |
| Commodore Capital LP |
| 1.14% | 1.12% | #8 | $19.2M | 3.3M | $19.3M | 3.3M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.03% | #25 | $16.2M | 2.8M | $16.4M | 2.8M | 00.00% | Unchanged |
| Saturn V Capital Management LP |
| 1.78% | 0.8% | #2 | $12.4M | 2.1M | $4.4M | 739,960 | +1.4M+183.95% | Add |
| QVT Financial LP |
| 0.66% | 0.57% | #12 | $11.2M | 1.9M | $7.8M | 1.3M | +584,560+44.60% | Add |
| ADAR1 Capital Management, LLC |
| 0.48% | 0.22% | #13 | $10.4M | 1.8M | $3.8M | 630,403 | +1.1M+179.07% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.12% | 0.16% | #22 | $9.7M | 1.6M | $9.0M | 1.5M | +129,000+8.56% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #43 | $9.3M | 1.6M | $3.1M | 527,691 | +1.1M+200.22% | Add |
| Affinity Asset Advisors, LLC |
| 0.39% | 0.79% | #17 | $8.6M | 1.5M | $15.3M | 2.6M | -1.1M-42.90% | Reduce |
| STEMPOINT CAPITAL LP |
| 1.15% | 0.83% | #7 | $8.1M | 1.4M | $4.5M | 753,520 | +614,695+81.58% | Add |
| Ikarian Capital, LLC |
| 0.76% | 0.58% | #11 | $7.2M | 1.2M | $7.1M | 1.2M | +25,000+2.09% | Add |
| EcoR1 Capital, LLC |
| 0.34% | 0.3% | #19 | $7.0M | 1.2M | $7.0M | 1.2M | 00.00% | Unchanged |
| Vestal Point Capital, LP |
| 0.16% | 0.09% | #21 | $6.9M | 1.2M | $3.0M | 511,000 | +662,956+129.74% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #57 | $5.9M | 1.0M | $1.2M | 194,963 | +806,674+413.76% | Add |
| Boxer Capital Management, LLC |
| 0.4% | 0.7% | #16 | $5.3M | 900,000 | $5.4M | 900,000 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $4.4M | 747,352 | $2.9M | 486,850 | +260,502+53.51% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #49 | $3.4M | 573,946 | $909,844 | 152,915 | +421,031+275.34% | Add |
| FMR LLC |
| <0.01% | <0.01% | #64 | $3.1M | 528,284 | $3.1M | 529,346 | -1,062-0.20% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $3.0M | 505,953 | $906,814 | 209,426 | +296,527+141.59% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $3.0M | 500,086 | $619,574 | 104,130 | +395,956+380.25% | Add |
| PFIZER INC |
| 1.69% | 7.05% | #3 | $2.9M | 538,841 | $16.8M | 2.8M | -2.3M-81.02% | Reduce |
| Foresite Capital Management VI LLC |
| 0.41% | 0.58% | #15 | $2.7M | 450,000 | $2.7M | 450,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #67 | $2.4M | 407,532 | $0 | 0 | +407,532 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #42 | $2.4M | 406,450 | $1.4M | 231,862 | +174,588+75.30% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.03% | #24 | $2.2M | 379,177 | $2.2M | 374,506 | +4,671+1.25% | Add |
| KVP Capital Advisors, LP |
| 1.62% | 1.66% | #4 | $2.2M | 373,128 | $2.2M | 373,128 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #37 | $2.1M | 350,902 | $1.9M | 318,186 | +32,716+10.28% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #36 | $1.9M | 321,702 | $1.9M | 313,300 | +8,402+2.68% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #52 | $1.8M | 300,719 | $190,983 | 32,098 | +268,621+836.88% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #47 | $1.7M | 282,207 | $0 | 0 | +282,207 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #53 | $1.6M | 265,314 | $1.4M | 241,027 | +24,287+10.08% | Add |
| Jump Financial, LLC |
| 0.01% | <0.01% | #28 | $1.4M | 231,600 | $166,975 | 28,063 | +203,537+725.29% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #63 | $1.0M | 174,395 | $185,021 | 31,096 | +143,299+460.83% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #51 | $812,070 | 137,639 | $9.0M | 1.5M | -1.4M-90.87% | Reduce |
| XTX Topco Ltd |
| 0.01% | 0.01% | #29 | $803,722 | 136,224 | $712,286 | 119,712 | +16,512+13.79% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #74 | $798,270 | 135,300 | $1.9M | 312,786 | -177,486-56.74% | Reduce |
| Alberta Investment Management Corp |
| <0.01% | <0.01% | #34 | $785,880 | 133,200 | $792,540 | 133,200 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | — | #56 | $744,604 | 126,204 | $0 | 0 | +126,204 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #65 | $733,754 | 124,365 | $0 | 0 | +124,365 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #66 | $623,901 | 105,746 | $1.0M | 169,833 | -64,087-37.74% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #83 | $572,495 | 97,033 | $812,312 | 136,523 | -39,490-28.93% | Reduce |
| ALPS ADVISORS INC |
| <0.01% | <0.01% | #35 | $568,843 | 96,414 | $417,642 | 70,192 | +26,222+37.36% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #30 | $503,553 | 85,348 | $507,821 | 85,348 | 00.00% | Unchanged |
