| Venrock Adviser, LLC |
| 0.77% | 0.69% | #9 | $25.5M | 3.9M | $18.5M | 3.9M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.41% | 0.36% | #11 | $21.6M | 3.3M | $18.4M | 3.8M | -561,443-14.65% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.01% | #27 | $20.2M | 3.1M | $3.4M | 700,000 | +2.4M+337.14% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #37 | $17.7M | 2.7M | $11.6M | 2.4M | +266,315+11.02% | Add |
| Rosalind Advisors, Inc. |
| 3.06% | 2.95% | #2 | $12.9M | 2.0M | $7.4M | 1.5M | +425,000+27.74% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 1.4% | 0.75% | #6 | $10.7M | 1.6M | $4.7M | 987,090 | +633,663+64.20% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 2.78% | 2.1% | #3 | $10.2M | 1.5M | $7.4M | 1.5M | 00.00% | Unchanged |
| DCF Advisers, LLC |
| 1.68% | 0.89% | #4 | $9.5M | 1.4M | $3.3M | 691,988 | +743,000+107.37% | Add |
| Sio Capital Management, LLC |
| 1.42% | — | #5 | $8.6M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Nan Fung Group Holdings Ltd |
| 4.96% | 1.82% | #1 | $6.5M | 987,222 | $2.2M | 460,000 | +527,222+114.61% | Add |
| Boxer Capital Management, LLC |
| 0.39% | 0.4% | #12 | $5.2M | 790,000 | $3.1M | 640,000 | +150,000+23.44% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #55 | $5.2M | 779,259 | $4.4M | 915,647 | -136,388-14.90% | Reduce |
| Logos Global Management LP |
| 0.21% | — | #16 | $5.0M | 750,000 | $0 | 0 | +750,000 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #59 | $3.9M | 586,016 | $2.4M | 498,325 | +87,691+17.60% | Add |
| DAFNA Capital Management LLC |
| 0.65% | 0.54% | #10 | $3.4M | 514,061 | $2.4M | 498,361 | +15,700+3.15% | Add |
| Walleye Capital LLC |
| 0.01% | — | #32 | $3.3M | 502,554 | $0 | 0 | +502,554 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #67 | $3.1M | 461,886 | $1.3M | 227,661 | +234,225+102.88% | Add |
| Knott David M Jr |
| 1.3% | 1.02% | #7 | $2.4M | 370,000 | $1.7M | 350,000 | +20,000+5.71% | Add |
| Stonepine Capital Management, LLC |
| 0.35% | 0.26% | #13 | $2.3M | 330,530 | $643,488 | 134,060 | +196,470+146.55% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #64 | $2.3M | 349,903 | $510,475 | 106,349 | +243,554+229.01% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #69 | $2.2M | 337,435 | $0 | 0 | +337,435 | New Buy |
| DIADEMA PARTNERS LP |
| 0.24% | — | #14 | $2.0M | 300,000 | $0 | 0 | +300,000 | New Buy |
| AdvisorShares Investments LLC |
| 0.23% | 0.17% | #15 | $1.9M | 292,711 | $938,899 | 195,604 | +97,107+49.64% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #50 | $1.8M | 269,300 | $534,240 | 111,300 | +158,000+141.96% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #72 | $1.6M | 237,828 | $9,694 | 2,244 | +235,584+10,498.40% | Add |
| ROYCE & ASSOCIATES LP |
| 0.01% | 0.01% | #31 | $1.5M | 232,078 | $744,240 | 155,050 | +77,028+49.68% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #66 | $1.4M | 218,726 | $1.1M | 238,302 | -19,576-8.21% | Reduce |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.85% | — | #8 | $1.4M | 204,424 | $0 | 0 | +204,424 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #46 | $1.3M | 191,193 | $0 | 0 | +191,193 | New Buy |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #47 | $1.1M | 167,600 | $16,618 | 3,462 | +164,138+4,741.13% | Add |
| Pale Fire Capital SE |
| 0.07% | 0.06% | #23 | $1.0M | 153,505 | $736,824 | 153,505 | 00.00% | Unchanged |
| PDT Partners, LLC |
| 0.05% | — | #25 | $993,463 | 150,297 | $0 | 0 | +150,297 | New Buy |
| Eversept Partners, LP |
| 0.05% | — | #26 | $967,724 | 146,403 | $0 | 0 | +146,403 | New Buy |
| Ikarian Capital, LLC |
| 0.09% | 0.05% | #20 | $873,532 | 132,153 | $634,334 | 132,153 | 00.00% | Unchanged |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #48 | $823,989 | 124,658 | $897,000 | 187,052 | -62,394-33.36% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #52 | $703,681 | 106,457 | $94,483 | 19,684 | +86,773+440.83% | Add |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.01% | #29 | $537,248 | 81,278 | $150,134 | 31,278 | +50,000+159.86% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #92 | $533,552 | 80,719 | $139,805 | 29,126 | +51,593+177.14% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #73 | $517,002 | 78,215 | $0 | 0 | +78,215 | New Buy |
| Altshuler Shaham Ltd |
| 0.01% | — | #39 | $475,920 | 72,000 | $0 | 0 | +72,000 | New Buy |
| Independent Advisor Alliance |
| 0.01% | — | #34 | $462,259 | 69,933 | $0 | 0 | +69,933 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #63 | $408,379 | 61,782 | $0 | 0 | +61,782 | New Buy |
| Blue Owl Capital Holdings LP |
| 0.06% | — | #24 | $396,012 | 59,911 | $0 | 0 | +59,911 | New Buy |
| Persistent Asset Partners Ltd |
| 0.12% | — | #17 | $393,224 | 51,234 | $0 | 0 | +51,234 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | — | #41 | $309,275 | 46,789 | $0 | 0 | +46,789 | New Buy |
| PEAK6 LLC |
| <0.01% | <0.01% | #54 | $286,986 | 43,417 | $300,466 | 62,597 | -19,180-30.64% | Reduce |
| Fore Capital, LLC |
| 0.08% | 0.11% | #21 | $240,743 | 36,421 | $174,821 | 36,421 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #81 | $234,000 | 35,537 | $151,000 | 31,592 | +3,945+12.49% | Add |
| Mitsubishi UFJ Asset Management (UK) Ltd. |
| 0.1% | 0.04% | #19 | $204,910 | 31,000 | $72,000 | 15,000 | +16,000+106.67% | Add |
| PDS Planning, Inc |
| 0.01% | 0.01% | #33 | $200,574 | 30,344 | $145,499 | 30,344 | 00.00% | Unchanged |
