| FMR LLC |
| <0.01% | <0.01% | #25 | $11.8M | 2.7M | $10.5M | 2.7M | +1,214+0.04% | Add |
| BML Capital Management, LLC |
| 6.21% | 4.69% | #1 | $10.9M | 2.5M | $7.3M | 1.9M | +617,500+32.46% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $4.3M | 998,961 | $3.1M | 808,285 | +190,676+23.59% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.05% | 0.06% | #7 | $3.6M | 833,333 | $3.2M | 833,333 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $3.4M | 780,134 | $2.9M | 763,822 | +16,312+2.14% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #32 | $2.9M | 665,847 | $3.6M | 949,397 | -283,550-29.87% | Reduce |
| PFM Health Sciences, LP |
| 0.22% | 0.21% | #4 | $2.5M | 582,122 | $2.3M | 594,630 | -12,508-2.10% | Reduce |
| Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #15 | $1.9M | 434,341 | $2.0M | 526,585 | -92,244-17.52% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #67 | $1.8M | 418,211 | $4.9M | 1.3M | -845,008-66.89% | Reduce |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #17 | $1.5M | 339,438 | $1.9M | 504,093 | -164,655-32.66% | Reduce |
| Peapod Lane Capital LLC |
| 0.97% | — | #3 | $1.4M | 331,951 | $0 | 0 | +331,951 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #23 | $915,809 | 211,993 | $0 | 0 | +211,993 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $884,538 | 204,652 | $1.6M | 421,373 | -216,721-51.43% | Reduce |
| Stratos Wealth Partners, LTD. |
| 0.01% | 0.01% | #11 | $866,359 | 200,546 | $770,097 | 200,546 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #39 | $822,048 | 190,289 | $969,596 | 252,499 | -62,210-24.64% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $786,166 | 181,983 | $6.1M | 433,175 | -251,192-57.99% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #28 | $785,350 | 181,794 | $0 | 0 | +181,794 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #45 | $749,348 | 173,460 | $358,503 | 93,360 | +80,100+85.80% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #53 | $601,331 | 139,197 | $668,582 | 174,110 | -34,913-20.05% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #55 | $555,219 | 128,523 | $1.2M | 300,780 | -172,257-57.27% | Reduce |
| XTX Topco Ltd |
| 0.01% | 0.01% | #12 | $538,661 | 124,690 | $547,008 | 142,450 | -17,760-12.47% | Reduce |
| Catalio Capital Management, LP |
| 0.1% | 0.09% | #6 | $510,965 | 118,279 | $454,191 | 118,279 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #37 | $496,420 | 114,912 | $428,694 | 111,639 | +3,273+2.93% | Add |
| GMT CAPITAL CORP |
| 0.02% | 0.01% | #10 | $423,827 | 98,108 | $162,897 | 42,421 | +55,687+131.27% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #44 | $391,828 | 90,698 | $435,032 | 113,365 | -22,667-19.99% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #58 | $361,061 | 83,579 | $1.4M | 353,200 | -269,621-76.34% | Reduce |
| PURA VIDA INVESTMENTS, LLC |
| 0.97% | 2.15% | #2 | $359,999 | 83,333 | $319,999 | 83,333 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #77 | $350,810 | 81,206 | $1.3M | 334,994 | -253,788-75.76% | Reduce |
| C WorldWide Group Holding A/S |
| 0.01% | 0.01% | #13 | $287,997 | 66,666 | $256,000 | 66,666 | 00.00% | Unchanged |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #20 | $225,189 | 52,127 | $152,590 | 39,737 | +12,390+31.18% | Add |
| Marquette Asset Management, LLC |
| 0.03% | — | #9 | $211,598 | 48,981 | $0 | 0 | +48,981 | New Buy |
| NATIONAL BANK OF CANADA /FI/ |
| <0.01% | <0.01% | #34 | $197,087 | 45,622 | $176,808 | 46,164 | -542-1.17% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #69 | $188,239 | 43,574 | $481,678 | 125,437 | -81,863-65.26% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #29 | $187,609 | 43,428 | $852,768 | 222,075 | -178,647-80.44% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #61 | $184,771 | 42,771 | $41,441 | 10,792 | +31,979+296.32% | Add |
| Centiva Capital, LP |
| <0.01% | <0.01% | #19 | $171,871 | 39,785 | $194,761 | 50,719 | -10,934-21.56% | Reduce |
| Clayton Partners LLC |
| 0.11% | — | #5 | $162,117 | 37,527 | $0 | 0 | +37,527 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #74 | $153,887 | 35,622 | $152,000 | 39,427 | -3,805-9.65% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $151,416 | 35,050 | $149,000 | 39,755 | -4,705-11.83% | Reduce |
| Jain Global LLC |
| <0.01% | — | #24 | $142,970 | 33,095 | $0 | 0 | +33,095 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #30 | $142,063 | 32,885 | $0 | 0 | +32,885 | New Buy |
| Mariner, LLC |
| <0.01% | <0.01% | #36 | $140,026 | 32,413 | $70,894 | 18,470 | +13,943+75.49% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $123,634 | 28,619 | $164,893 | 42,941 | -14,322-33.35% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #71 | $120,523 | 27,899 | $239,460 | 62,360 | -34,461-55.26% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #52 | $116,394 | 26,943 | $103,461 | 26,943 | 00.00% | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #16 | $108,000 | 25,000 | $0 | 0 | +25,000 | New Buy |
| BANK OF MONTREAL /CAN/ |
| <0.01% | <0.01% | #60 | $106,609 | 24,678 | $264,957 | 18,012 | +6,666+37.01% | Add |
| Squarepoint Ops LLC |
| <0.01% | — | #38 | $98,073 | 22,702 | $0 | 0 | +22,702 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #51 | $87,696 | 20,300 | $26,945 | 7,017 | +13,283+189.30% | Add |
| Catalyst Funds Management Pty Ltd |
| <0.01% | — | #14 | $82,948 | 19,201 | $0 | 0 | +19,201 | New Buy |
