| Siren, L.L.C. |
| 0.74% | 0.43% | #9 | $36.4M | 3.3M | $15.3M | 2.9M | +400,000+13.74% | Add |
| TCG Crossover Management, LLC |
| 0.8% | 0.46% | #8 | $33.3M | 3.0M | $16.0M | 3.0M | 00.00% | Unchanged |
| Redmile Group, LLC |
| 1.6% | 0.76% | #4 | $23.8M | 2.2M | $11.4M | 2.2M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.49% | 0.42% | #11 | $14.8M | 1.3M | $11.3M | 2.1M | -800,000-37.27% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $14.6M | 1.3M | $6.6M | 1.2M | +83,518+6.70% | Add |
| Tetragon Partners GP Ltd |
| 1.84% | 0.64% | #2 | $11.7M | 1.1M | $3.3M | 630,161 | +434,095+68.89% | Add |
| Nextech Invest Ltd. |
| 0.5% | 0.35% | #10 | $10.5M | 952,400 | $5.0M | 952,400 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $10.0M | 909,279 | $5.7M | 1.1M | -164,912-15.35% | Reduce |
| Ikarian Capital, LLC |
| 0.97% | 0.14% | #6 | $9.1M | 830,784 | $1.7M | 865,784 | -35,000-4.04% | Reduce |
| Soleus Capital Management, L.P. |
| 0.24% | — | #14 | $6.9M | 630,000 | $0 | 0 | +630,000 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #29 | $6.7M | 610,980 | $0 | 0 | +610,980 | New Buy |
| 5AM Venture Management, LLC |
| 1.82% | 0.7% | #3 | $5.2M | 476,200 | $2.5M | 476,200 | 00.00% | Unchanged |
| Caption Management, LLC |
| 0.02% | — | #23 | $5.1M | 460,376 | $0 | 0 | +460,376 | New Buy |
| GREAT POINT PARTNERS LLC |
| 0.93% | 1.24% | #7 | $4.9M | 450,000 | $5.4M | 1.0M | -570,489-55.90% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $4.4M | 403,172 | $6.3M | 1.2M | -804,552-66.62% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #48 | $4.3M | 387,551 | $531,885 | 100,927 | +286,624+283.99% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #42 | $4.1M | 370,052 | $0 | 0 | +370,052 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.05% | #16 | $3.7M | 338,373 | $907,267 | 172,157 | +166,216+96.55% | Add |
| SummitTX Capital, L.P. |
| 0.09% | — | #19 | $3.6M | 326,648 | $0 | 0 | +326,648 | New Buy |
| Schonfeld Strategic Advisors LLC |
| 0.01% | — | #27 | $3.0M | 269,348 | $0 | 0 | +269,348 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #49 | $2.7M | 243,152 | $1.3M | 246,937 | -3,785-1.53% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $2.6M | 233,719 | $813,588 | 154,381 | +79,338+51.39% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #62 | $2.4M | 219,917 | $1.1M | 204,777 | +15,140+7.39% | Add |
| BANK OF MONTREAL /CAN/ |
| <0.01% | <0.01% | #43 | $2.2M | 201,734 | $1.1M | 202,901 | -1,167-0.58% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.01% | #22 | $2.2M | 198,347 | $1.1M | 209,088 | -10,741-5.14% | Reduce |
| Propel Bio Management, LLC |
| 1.1% | — | #5 | $2.1M | 191,733 | $0 | 0 | +191,733 | New Buy |
| FRED ALGER MANAGEMENT, LLC |
| 0.01% | — | #30 | $1.9M | 177,000 | $0 | 0 | +177,000 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #36 | $1.8M | 163,945 | $551,005 | 104,555 | +59,390+56.80% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #41 | $1.7M | 158,950 | $778,210 | 147,668 | +11,282+7.64% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #55 | $1.7M | 155,929 | $276,733 | 52,511 | +103,418+196.95% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #40 | $1.3M | 121,004 | $85,390 | 16,203 | +104,801+646.80% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #46 | $1.3M | 122,834 | $639,965 | 122,834 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| 0.01% | — | #26 | $1.3M | 118,129 | $0 | 0 | +118,129 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #39 | $1.3M | 115,918 | $471,502 | 89,469 | +26,449+29.56% | Add |
| XTX Topco Ltd |
| 0.02% | 0.01% | #24 | $1.2M | 107,579 | $558,631 | 106,002 | +1,577+1.49% | Add |
| M28 Capital Management LP |
| 2.36% | 0.99% | #1 | $1.1M | 101,203 | $533,340 | 101,203 | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #44 | $790,989 | 72,039 | $893,877 | 169,616 | -97,577-57.53% | Reduce |
| Birchview Capital, LP |
| 0.35% | — | #13 | $781,974 | 71,218 | $0 | 0 | +71,218 | New Buy |
| Seven Fleet Capital Management LP |
| 0.11% | 0.26% | #18 | $659,975 | 60,107 | $826,120 | 156,759 | -96,652-61.66% | Reduce |
| Ishara Investments LP |
| 0.44% | 0.7% | #12 | $608,850 | 55,350 | $740,435 | 140,500 | -85,150-60.60% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #45 | $337,613 | 30,748 | $63,000 | 11,994 | +18,754+156.36% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #65 | $324,327 | 29,538 | $155,665 | 29,538 | 00.00% | Unchanged |
| Virtu Financial LLC |
| 0.01% | — | #28 | $281,538 | 25,641 | $0 | 0 | +25,641 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #64 | $277,574 | 25,280 | $156,904 | 29,773 | -4,493-15.09% | Reduce |
| Trexquant Investment LP |
| <0.01% | — | #38 | $261,785 | 23,842 | $0 | 0 | +23,842 | New Buy |
| Verdad Advisers, LP |
| 0.21% | — | #15 | $223,992 | 20,400 | $0 | 0 | +20,400 | New Buy |
| Scientech Research LLC |
| 0.17% | — | #17 | $210,080 | 19,133 | $0 | 0 | +19,133 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #50 | $185,891 | 16,930 | $0 | 0 | +16,930 | New Buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
| 0.04% | — | #21 | $179,347 | 16,334 | $0 | 0 | +16,334 | New Buy |
| Persistent Asset Partners Ltd |
| 0.05% | — | #20 | $166,567 | 15,170 | $0 | 0 | +15,170 | New Buy |
