| BVF INC/IL |
| 8.25% | 2.59% | #1 | $322.7M | 7.6M | $81.3M | 2.6M | +5.0M+193.14% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #26 | $72.1M | 1.7M | $63.5M | 1.6M | +50,171+3.05% | Add |
| FMR LLC |
| <0.01% | <0.01% | #28 | $68.2M | 1.6M | $40.9M | 1.3M | +302,558+23.22% | Add |
| Woodline Partners LP |
| 0.15% | 0.08% | #10 | $47.4M | 1.1M | $20.1M | 640,001 | +474,362+74.12% | Add |
| Newtyn Management, LLC |
| 3.76% | — | #3 | $30.1M | 709,247 | $0 | 0 | +709,247 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $29.4M | 691,971 | $20.3M | 646,914 | +45,057+6.96% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $21.5M | 505,165 | $17.2M | 549,796 | -44,631-8.12% | Reduce |
| Opaleye Management Inc. |
| 1.3% | 1.24% | #5 | $14.4M | 338,374 | $9.4M | 300,000 | +38,374+12.79% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $10.4M | 245,321 | $7.2M | 229,766 | +15,555+6.77% | Add |
| WATER ISLAND CAPITAL LLC |
| 0.96% | — | #6 | $10.3M | 242,000 | $0 | 0 | +242,000 | New Buy |
| ALPINE ASSOCIATES MANAGEMENT INC. |
| 0.64% | — | #7 | $10.2M | 239,318 | $0 | 0 | +239,318 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $9.6M | 226,507 | $6.4M | 204,920 | +21,587+10.53% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #53 | $8.4M | 197,764 | $6.1M | 193,148 | +4,616+2.39% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #33 | $7.5M | 177,106 | $4.2M | 133,360 | +43,746+32.80% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | — | #29 | $6.3M | 149,523 | $0 | 0 | +149,523 | New Buy |
| TORNO CAPITAL, LLC |
| 0.17% | — | #9 | $5.9M | 139,700 | $0 | 0 | +139,700 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #47 | $5.7M | 134,023 | $752,566 | 23,990 | +110,033+458.66% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $4.1M | 96,179 | $2.9M | 93,490 | +2,689+2.88% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $3.8M | 90,348 | $2.7M | 85,797 | +4,551+5.30% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #23 | $3.6M | 84,391 | $0 | 0 | +84,391 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #43 | $3.2M | 75,348 | $2.4M | 74,984 | +364+0.49% | Add |
| Verition Fund Management LLC |
| <0.01% | — | #25 | $3.0M | 70,601 | $0 | 0 | +70,601 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #40 | $3.0M | 70,189 | $2.1M | 66,664 | +3,525+5.29% | Add |
| Simcoe Capital LLC |
| 1.76% | 1.96% | #4 | $2.9M | 68,053 | $2.1M | 68,053 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #57 | $2.4M | 57,492 | $791,120 | 25,219 | +32,273+127.97% | Add |
| TLS Advisors LLC |
| 5.27% | 8.55% | #2 | $1.8M | 42,165 | $3.6M | 114,867 | -72,702-63.29% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $1.6M | 36,744 | $817,973 | 26,075 | +10,669+40.92% | Add |
| XTX Topco Ltd |
| 0.02% | — | #19 | $1.5M | 35,046 | $0 | 0 | +35,046 | New Buy |
| CREDIT INDUSTRIEL ET COMMERCIAL |
| 0.09% | — | #14 | $1.5M | 34,853 | $0 | 0 | +34,853 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #31 | $1.5M | 34,621 | $0 | 0 | +34,621 | New Buy |
| RBF Capital, LLC |
| 0.05% | 0.05% | #16 | $1.3M | 30,000 | $941,100 | 30,000 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $1.3M | 30,018 | $120,758 | 3,992 | +26,026+651.95% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #61 | $1.2M | 28,460 | $3.5M | 110,238 | -81,778-74.18% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $1.2M | 28,078 | $851,727 | 27,151 | +927+3.41% | Add |
| EQUITEC PROPRIETARY MARKETS, LLC |
| 0.21% | — | #8 | $1.2M | 28,000 | $0 | 0 | +28,000 | New Buy |
| SIERRA SUMMIT ADVISORS LLC |
| 0.12% | — | #13 | $1.1M | 25,740 | $0 | 0 | +25,740 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #62 | $1.0M | 23,843 | $2.3M | 72,533 | -48,690-67.13% | Reduce |
| CSS LLC/IL |
| 0.03% | — | #17 | $890,842 | 20,961 | $0 | 0 | +20,961 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #70 | $855,185 | 20,122 | $752,818 | 23,998 | -3,876-16.15% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #58 | $781,490 | 18,388 | $398,587 | 12,706 | +5,682+44.72% | Add |
| MARTINGALE ASSET MANAGEMENT L P |
| 0.01% | — | #21 | $518,500 | 12,200 | $0 | 0 | +12,200 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #50 | $486,663 | 11,451 | $367,175 | 11,705 | -254-2.17% | Reduce |
| Yakira Capital Management, Inc. |
| 0.12% | — | #12 | $438,218 | 10,311 | $0 | 0 | +10,311 | New Buy |
| DIVERSIFIED MANAGEMENT INC |
| 0.09% | 0.05% | #15 | $425,000 | 10,000 | $313,700 | 10,000 | 00.00% | Unchanged |
| REGIONS FINANCIAL CORP |
| <0.01% | <0.01% | #30 | $393,125 | 9,250 | $290,173 | 9,250 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #65 | $388,408 | 9,139 | $264,983 | 8,447 | +692+8.19% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #75 | $361,017 | 8,495 | $121,230 | 3,865 | +4,630+119.79% | Add |
| Kintayl Capital LP |
| 0.14% | — | #11 | $360,230 | 8,476 | $0 | 0 | +8,476 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #81 | $297,712 | 7,005 | $214,000 | 6,803 | +202+2.97% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #83 | $292,314 | 6,878 | $345,634 | 11,018 | -4,140-37.57% | Reduce |
