| RA CAPITAL MANAGEMENT, L.P. |
| 1.51% | 0.67% | #5 | $174.2M | 18.0M | $63.5M | 9.9M | +8.1M+82.23% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.07% | — | #16 | $25.3M | 2.6M | $0 | 0 | +2.6M | New Buy |
| Blackstone Inc. |
| 0.07% | — | #17 | $23.3M | 2.4M | $0 | 0 | +2.4M | New Buy |
| 5AM Venture Management, LLC |
| 7.93% | 4.21% | #1 | $22.8M | 2.4M | $15.2M | 2.4M | 00.00% | Unchanged |
| Venrock Adviser, LLC |
| 0.6% | 0.39% | #10 | $19.8M | 2.0M | $10.4M | 1.6M | +434,027+26.97% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #29 | $19.4M | 2.0M | $3.4M | 520,327 | +1.5M+283.84% | Add |
| Caligan Partners LP |
| 0.79% | — | #8 | $16.8M | 1.7M | $0 | 0 | +1.7M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $9.5M | 981,815 | $1.3M | 207,686 | +774,129+372.74% | Add |
| Samsara BioCapital, LLC |
| 0.76% | — | #9 | $9.3M | 954,861 | $0 | 0 | +954,861 | New Buy |
| Blue Owl Capital Holdings LP |
| 1.24% | — | #7 | $8.5M | 874,542 | $0 | 0 | +874,542 | New Buy |
| Propel Bio Management, LLC |
| 3.54% | 0.6% | #2 | $6.8M | 696,436 | $949,818 | 146,369 | +550,067+375.81% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #43 | $6.7M | 694,726 | $1.4M | 213,388 | +481,338+225.57% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #33 | $5.9M | 609,376 | $102,203 | 15,870 | +593,506+3,739.80% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.53% | — | #11 | $5.1M | 525,000 | $0 | 0 | +525,000 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $3.4M | 353,845 | $655,451 | 101,695 | +252,150+247.95% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | — | #20 | $3.0M | 314,375 | $0 | 0 | +314,375 | New Buy |
| Nantahala Capital Management, LLC |
| 0.1% | — | #15 | $2.9M | 300,000 | $0 | 0 | +300,000 | New Buy |
| Revelation Capital Management, LLC |
| 2.65% | 2.86% | #3 | $2.9M | 299,311 | $1.9M | 299,311 | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| 0.01% | <0.01% | #24 | $2.7M | 273,615 | $644,000 | 100,000 | +173,615+173.62% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 1.76% | — | #4 | $2.5M | 260,416 | $0 | 0 | +260,416 | New Buy |
| KVP Capital Advisors, LP |
| 1.42% | — | #6 | $1.9M | 200,000 | $0 | 0 | +200,000 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #35 | $1.9M | 194,108 | $1.3M | 194,108 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #38 | $1.8M | 184,020 | $9,834 | 1,527 | +182,493+11,951.08% | Add |
| SEVEN GRAND MANAGERS, LLC |
| 0.07% | — | #18 | $1.7M | 175,000 | $0 | 0 | +175,000 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #51 | $1.6M | 165,764 | $230,707 | 35,824 | +129,940+362.72% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #31 | $1.5M | 151,000 | $515,445 | 80,038 | +70,962+88.66% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $1.4M | 148,393 | $211,296 | 32,810 | +115,583+352.28% | Add |
| ADAR1 Capital Management, LLC |
| 0.05% | — | #19 | $1.2M | 118,624 | $0 | 0 | +118,624 | New Buy |
| Simplify Asset Management Inc. |
| 0.01% | <0.01% | #23 | $983,144 | 101,355 | $149,601 | 23,230 | +78,125+336.31% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $824,500 | 85,000 | $225,400 | 35,000 | +50,000+142.86% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $762,178 | 78,575 | $740,864 | 115,041 | -36,466-31.70% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $741,303 | 76,423 | $78,620 | 12,208 | +64,215+526.01% | Add |
| DAFNA Capital Management LLC |
| 0.12% | — | #14 | $650,880 | 67,101 | $0 | 0 | +67,101 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | — | #27 | $478,647 | 49,345 | $0 | 0 | +49,345 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #45 | $434,705 | 44,815 | $131,183 | 20,370 | +24,445+120.00% | Add |
| XTX Topco Ltd |
| 0.01% | <0.01% | #25 | $412,337 | 42,509 | $130,539 | 20,270 | +22,239+109.71% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #59 | $301,796 | 31,113 | $0 | 0 | +31,113 | New Buy |
| Velan Capital Investment Management LP |
| 0.15% | 0.1% | #13 | $242,500 | 25,000 | $161,000 | 25,000 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #37 | $222,518 | 22,940 | $0 | 0 | +22,940 | New Buy |
| Atom Investors LP |
| 0.02% | — | #21 | $221,684 | 22,854 | $0 | 0 | +22,854 | New Buy |
| BAILARD, INC. |
| <0.01% | <0.01% | #28 | $200,790 | 20,700 | $133,308 | 20,700 | 00.00% | Unchanged |
| Spark Investment Management LLC |
| 0.31% | — | #12 | $160,050 | 16,500 | $0 | 0 | +16,500 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $153,066 | 15,780 | $73,835 | 11,465 | +4,315+37.64% | Add |
| Squarepoint Ops LLC |
| <0.01% | — | #41 | $144,094 | 14,855 | $0 | 0 | +14,855 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #52 | $135,606 | 13,980 | $0 | 0 | +13,980 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | — | #50 | $116,187 | 11,978 | $0 | 0 | +11,978 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #58 | $115,391 | 11,896 | $0 | 0 | +11,896 | New Buy |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #47 | $59,170 | 6,100 | $0 | 0 | +6,100 | New Buy |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #53 | $56,852 | 5,861 | $35,362 | 5,491 | +370+6.74% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #62 | $53,156 | 5,480 | $9,660 | 1,500 | +3,980+265.33% | Add |
