| BAKER BROS. ADVISORS LP |
| 0.19% | 0.37% | #9 | $37.3M | 5.1M | $64.0M | 5.1M | 00.00% | Unchanged |
| 5AM Venture Management, LLC |
| 10.37% | 14.21% | #1 | $29.9M | 4.1M | $51.2M | 4.1M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #64 | $19.0M | 2.6M | $29.8M | 2.4M | +224,540+9.52% | Add |
| Merck & Co., Inc. |
| 2.43% | 6.28% | #2 | $12.8M | 1.7M | $22.0M | 1.7M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #73 | $9.3M | 1.3M | $15.9M | 1.3M | +13,621+1.08% | Add |
| MPM BioImpact LLC |
| 0.56% | — | #4 | $9.2M | 1.3M | $0 | 0 | +1.3M | New Buy |
| TCG Crossover Management, LLC |
| 0.19% | 0.83% | #8 | $7.8M | 1.1M | $28.9M | 2.3M | -1.2M-53.65% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #43 | $7.0M | 954,419 | $13.1M | 1.0M | -80,363-7.77% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $5.6M | 763,959 | $6.6M | 519,356 | +244,603+47.10% | Add |
| StepStone Group LP |
| 2.33% | 4.63% | #3 | $5.3M | 761,277 | $9.6M | 761,277 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $5.3M | 717,430 | $8.4M | 667,347 | +50,083+7.50% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $5.1M | 699,537 | $1.0M | 79,493 | +620,044+780.00% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #81 | $4.4M | 596,677 | $6.7M | 533,798 | +62,879+11.78% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #57 | $4.0M | 542,316 | $6.6M | 526,043 | +16,273+3.09% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $3.8M | 496,457 | $174,749 | 14,847 | +481,610+3,243.82% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #29 | $3.0M | 400,862 | $4.2M | 333,169 | +67,693+20.32% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #62 | $2.9M | 394,323 | $2.7M | 215,018 | +179,305+83.39% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #53 | $2.8M | 376,136 | $4.1M | 324,471 | +51,665+15.92% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #66 | $2.3M | 309,942 | $3.0M | 234,992 | +74,950+31.89% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.02% | #19 | $2.2M | 303,459 | $4.2M | 333,914 | -30,455-9.12% | Reduce |
| Nantahala Capital Management, LLC |
| 0.07% | 0.07% | #10 | $2.2M | 300,575 | $2.0M | 159,332 | +141,243+88.65% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $1.9M | 254,130 | $2.8M | 220,494 | +33,636+15.25% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #74 | $1.5M | 197,136 | $2.7M | 214,751 | -17,615-8.20% | Reduce |
| Longaeva Partners L.P. |
| 0.03% | 0.1% | #13 | $1.4M | 195,237 | $2.6M | 204,978 | -9,741-4.75% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #95 | $1.4M | 191,650 | $2.0M | 346,756 | -155,106-44.73% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #37 | $1.4M | 191,000 | $2.6M | 202,084 | -11,084-5.48% | Reduce |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #40 | $1.4M | 188,839 | $896,247 | 71,018 | +117,821+165.90% | Add |
| Lynx1 Capital Management LP |
| 0.26% | 0.42% | #6 | $1.3M | 178,606 | $2.7M | 211,689 | -33,083-15.63% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #86 | $1.3M | 177,343 | $2.7M | 212,780 | -35,437-16.65% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #65 | $1.2M | 167,646 | $2.0M | 156,861 | +10,785+6.88% | Add |
| Woodline Partners LP |
| <0.01% | 0.01% | #31 | $1.1M | 145,600 | $2.7M | 215,977 | -70,377-32.59% | Reduce |
| Trexquant Investment LP |
| 0.01% | 0.01% | #22 | $1.0M | 140,143 | $1.0M | 82,733 | +57,410+69.39% | Add |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.01% | 0.03% | #17 | $772,800 | 105,000 | $1.3M | 105,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.01% | 0.03% | #18 | $701,680 | 95,337 | $1.6M | 129,562 | -34,225-26.42% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #61 | $699,524 | 95,044 | $2.3M | 181,148 | -86,104-47.53% | Reduce |
| Allspring Global Investments Holdings, LLC |
| <0.01% | <0.01% | #44 | $688,440 | 93,538 | $245,648 | 19,465 | +74,073+380.54% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | — | #11 | $647,717 | 88,005 | $0 | 0 | +88,005 | New Buy |
| ROYCE & ASSOCIATES LP |
| <0.01% | 0.02% | #25 | $610,159 | 82,902 | $1.5M | 120,845 | -37,943-31.40% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #67 | $586,599 | 79,701 | $983,994 | 77,971 | +1,730+2.22% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #89 | $581,955 | 79,070 | $964,509 | 76,427 | +2,643+3.46% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #56 | $533,747 | 72,520 | $891,679 | 70,656 | +1,864+2.64% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #87 | $518,107 | 70,395 | $886,934 | 70,280 | +115+0.16% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #55 | $448,018 | 60,872 | $1.1M | 87,453 | -26,581-30.39% | Reduce |
| CANTOR FITZGERALD, L. P. |
| <0.01% | 0.01% | #26 | $441,600 | 60,000 | $593,140 | 47,000 | +13,000+27.66% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #111 | $426,343 | 57,927 | $494,855 | 39,212 | +18,715+47.73% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #88 | $417,879 | 56,777 | $2.2M | 175,648 | -118,871-67.68% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #21 | $398,272 | 54,113 | $0 | 0 | +54,113 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $394,408 | 53,588 | $676,281 | 53,588 | 00.00% | Unchanged |
| ExodusPoint Capital Management, LP |
| <0.01% | — | #34 | $388,365 | 52,767 | $0 | 0 | +52,767 | New Buy |
| Nan Fung Group Holdings Ltd |
| 0.27% | 0.51% | #5 | $361,244 | 49,082 | $619,415 | 49,082 | 00.00% | Unchanged |
