| BVF INC/IL |
| 5.95% | 3.87% | #1 | $232.5M | 8.7M | $121.6M | 8.7M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.78% | 1.14% | #3 | $205.3M | 7.6M | $107.9M | 7.7M | -39,884-0.52% | Reduce |
| FMR LLC |
| 0.01% | <0.01% | #20 | $160.7M | 6.0M | $72.2M | 5.1M | +841,000+16.37% | Add |
| RTW INVESTMENTS, LP |
| 1.36% | 0.83% | #4 | $159.5M | 5.9M | $83.4M | 5.9M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 1.3% | — | #6 | $89.6M | 3.3M | $0 | 0 | +3.3M | New Buy |
| Avoro Capital Advisors LLC |
| 0.43% | 0.25% | #8 | $48.4M | 1.8M | $25.3M | 1.8M | 00.00% | Unchanged |
| Foresite Capital Management VI LLC |
| 3.93% | 0.96% | #2 | $25.3M | 940,493 | $4.4M | 315,492 | +625,001+198.10% | Add |
| Jefferies Financial Group Inc. |
| 0.13% | 0.07% | #11 | $19.1M | 712,300 | $10.0M | 712,300 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $12.9M | 480,287 | $6.4M | 455,618 | +24,669+5.41% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #26 | $12.8M | 477,408 | $5.8M | 412,416 | +64,992+15.76% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #25 | $8.7M | 323,399 | $13.2M | 937,898 | -614,499-65.52% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | — | #33 | $5.7M | 212,651 | $0 | 0 | +212,651 | New Buy |
| BRAIDWELL LP |
| 0.21% | — | #10 | $5.6M | 207,240 | $0 | 0 | +207,240 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.07% | 0.05% | #14 | $5.4M | 202,103 | $4.0M | 282,891 | -80,788-28.56% | Reduce |
| HighVista Strategies LLC |
| 0.97% | 0.83% | #7 | $4.3M | 158,770 | $3.0M | 213,212 | -54,442-25.53% | Reduce |
| Trexquant Investment LP |
| 0.02% | 0.01% | #17 | $4.1M | 153,767 | $981,500 | 69,808 | +83,959+120.27% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #36 | $4.0M | 148,673 | $629,818 | 44,795 | +103,878+231.90% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #39 | $2.8M | 105,752 | $920,424 | 65,464 | +40,288+61.54% | Add |
| XTX Topco Ltd |
| 0.03% | 0.01% | #16 | $2.3M | 86,986 | $732,385 | 52,090 | +34,896+66.99% | Add |
| AdvisorShares Investments LLC |
| 0.23% | 0.17% | #9 | $1.9M | 71,267 | $942,498 | 67,034 | +4,233+6.31% | Add |
| CenterBook Partners LP |
| 0.09% | 0.16% | #13 | $1.9M | 69,436 | $3.0M | 216,574 | -147,138-67.94% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #24 | $1.8M | 65,375 | $0 | 0 | +65,375 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $1.4M | 52,218 | $60,661 | 4,242 | +47,976+1,130.98% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | — | #27 | $1.4M | 50,882 | $0 | 0 | +50,882 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #30 | $1.3M | 46,697 | $1.3M | 91,108 | -44,411-48.75% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | — | #29 | $1.2M | 43,948 | $0 | 0 | +43,948 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #53 | $1.1M | 40,483 | $569,190 | 40,483 | 00.00% | Unchanged |
| Axxion S.A. |
| 0.07% | — | #15 | $972,250 | 36,170 | $0 | 0 | +36,170 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #28 | $921,393 | 34,278 | $260,954 | 18,560 | +15,718+84.69% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $855,967 | 31,844 | $459,551 | 32,685 | -841-2.57% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #40 | $681,274 | 25,345 | $0 | 0 | +25,345 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | — | #22 | $567,625 | 21,117 | $0 | 0 | +21,117 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #55 | $534,985 | 18,778 | $245,655 | 18,853 | -75-0.40% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | — | #32 | $495,398 | 18,430 | $0 | 0 | +18,430 | New Buy |
| Virtus Investment Advisers, LLC |
| 0.1% | 0.08% | #12 | $416,425 | 15,492 | $294,135 | 20,920 | -5,428-25.95% | Reduce |
| LETKO, BROSSEAU & ASSOCIATES INC |
| 0.01% | — | #21 | $414,624 | 15,425 | $0 | 0 | +15,425 | New Buy |
| China Universal Asset Management Co., Ltd. |
| 0.02% | 0.01% | #18 | $360,703 | 13,419 | $189,908 | 13,507 | -88-0.65% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #56 | $360,192 | 13,400 | $157,472 | 11,200 | +2,200+19.64% | Add |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #38 | $341,376 | 12,700 | $219,336 | 15,600 | -2,900-18.59% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #62 | $300,061 | 11,163 | $155,349 | 11,049 | +114+1.03% | Add |
| Lion Point Capital, LP |
| 1.31% | 0.86% | #5 | $274,176 | 10,200 | $143,412 | 10,200 | 00.00% | Unchanged |
| Eversept Partners, LP |
| 0.01% | — | #19 | $233,103 | 8,672 | $0 | 0 | +8,672 | New Buy |
| HSBC HOLDINGS PLC |
| <0.01% | — | #49 | $216,420 | 7,847 | $0 | 0 | +7,847 | New Buy |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #43 | $171,867 | 6,394 | $0 | 0 | +6,394 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #54 | $160,661 | 5,977 | $61,780 | 4,394 | +1,583+36.03% | Add |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #57 | $158,000 | 5,877 | $36,000 | 2,567 | +3,310+128.94% | Add |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #45 | $155,232 | 5,775 | $83,305 | 5,925 | -150-2.53% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #50 | $127,384 | 4,739 | $1,166 | 83 | +4,656+5,609.64% | Add |
| Mirae Asset Global Investments Co., Ltd. |
| <0.01% | <0.01% | #47 | $82,468 | 3,068 | $45,484 | 3,235 | -167-5.16% | Reduce |
| North Star Investment Management Corp. |
| <0.01% | <0.01% | #23 | $59,136 | 2,200 | $30,932 | 2,200 | 00.00% | Unchanged |
