| RA CAPITAL MANAGEMENT, L.P. |
| 0.27% | 0.24% | #8 | $30.6M | 10.8M | $22.8M | 10.8M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #59 | $17.8M | 6.3M | $9.5M | 4.5M | +1.8M+39.74% | Add |
| NEA Management Company, LLC |
| 0.64% | 0.43% | #5 | $10.1M | 3.6M | $7.5M | 3.6M | 00.00% | Unchanged |
| Samsara BioCapital, LLC |
| 0.82% | 0.72% | #4 | $9.9M | 3.5M | $7.4M | 3.5M | 00.00% | Unchanged |
| SR ONE CAPITAL MANAGEMENT, LP |
| 0.91% | 0.77% | #3 | $9.4M | 3.3M | $7.0M | 3.3M | 00.00% | Unchanged |
| GSK plc |
| 1.48% | 1.11% | #1 | $8.9M | 3.2M | $6.6M | 3.2M | 00.00% | Unchanged |
| Monaco Asset Management SAM |
| 0.53% | 0.98% | #6 | $6.7M | 2.4M | $5.3M | 2.5M | -148,532-5.89% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #41 | $6.4M | 2.3M | $3.8M | 1.8M | +450,651+24.97% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #73 | $6.3M | 2.2M | $4.2M | 2.0M | +214,994+10.69% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $5.3M | 1.9M | $4.3M | 2.0M | -174,083-8.50% | Reduce |
| WASATCH ADVISORS LP |
| 0.03% | 0.02% | #15 | $4.5M | 1.6M | $3.3M | 1.6M | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $3.9M | 1.4M | $2.7M | 1.3M | +100,772+8.00% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #78 | $3.6M | 1.3M | $2.6M | 1.2M | +48,635+3.93% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #69 | $3.6M | 1.3M | $2.7M | 1.3M | +17,592+1.39% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #25 | $3.3M | 1.2M | $3.7M | 1.7M | -554,720-32.02% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $3.0M | 1.1M | $1.3M | 595,726 | +458,525+76.97% | Add |
| AWM Investment Company, Inc. |
| 0.22% | 0.21% | #9 | $2.6M | 906,000 | $1.9M | 906,000 | 00.00% | Unchanged |
| Blackstone Inc. |
| 0.01% | — | #21 | $2.1M | 747,044 | $0 | 0 | +747,044 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #31 | $1.9M | 673,010 | $0 | 0 | +673,010 | New Buy |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #24 | $1.7M | 583,249 | $599,683 | 284,210 | +299,039+105.22% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #82 | $1.6M | 562,980 | $1.2M | 575,001 | -12,021-2.09% | Reduce |
| Peapod Lane Capital LLC |
| 1.05% | 1.15% | #2 | $1.6M | 549,923 | $1.4M | 676,212 | -126,289-18.68% | Reduce |
| Alyeska Investment Group, L.P. |
| <0.01% | 0.01% | #28 | $1.4M | 484,840 | $4.4M | 2.1M | -1.6M-76.74% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #60 | $1.4M | 483,211 | $730,923 | 346,593 | +136,618+39.42% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #53 | $1.3M | 469,555 | $940,634 | 445,798 | +23,757+5.33% | Add |
| T. Rowe Price Investment Management, Inc. |
| <0.01% | — | #37 | $1.3M | 455,033 | $0 | 0 | +455,033 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #79 | $1.2M | 433,982 | $812,349 | 385,000 | +48,982+12.72% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #75 | $1.1M | 371,425 | $880,232 | 417,172 | -45,747-10.97% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $985,366 | 348,186 | $692,164 | 328,040 | +20,146+6.14% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $915,955 | 323,659 | $307,402 | 145,688 | +177,971+122.16% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $854,422 | 301,916 | $574,087 | 272,079 | +29,837+10.97% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #19 | $820,658 | 289,985 | $324,552 | 153,816 | +136,169+88.53% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $746,479 | 263,773 | $979,559 | 473,217 | -209,444-44.26% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #92 | $586,701 | 207,315 | $318,484 | 150,940 | +56,375+37.35% | Add |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #29 | $501,017 | 177,038 | $217,011 | 102,849 | +74,189+72.13% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #67 | $459,900 | 162,509 | $753,127 | 356,932 | -194,423-54.47% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #103 | $372,499 | 131,625 | $299,418 | 141,904 | -10,279-7.24% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #91 | $370,659 | 130,975 | $276,357 | 130,975 | 00.00% | Unchanged |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.28% | 0.35% | #7 | $367,900 | 130,000 | $369,250 | 175,000 | -45,000-25.71% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #115 | $367,736 | 129,942 | $272,399 | 129,099 | +843+0.65% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | <0.01% | #23 | $357,539 | 126,339 | $130,681 | 61,934 | +64,405+103.99% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $347,524 | 122,800 | $227,458 | 107,800 | +15,000+13.91% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #87 | $344,042 | 121,570 | $260,571 | 123,493 | -1,923-1.56% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | — | #52 | $341,889 | 120,809 | $0 | 0 | +120,809 | New Buy |
| MACKENZIE FINANCIAL CORP |
| <0.01% | — | #54 | $325,985 | 115,189 | $0 | 0 | +115,189 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #90 | $324,978 | 114,833 | $232,108 | 110,004 | +4,829+4.39% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.04% | #17 | $320,928 | 113,402 | $606,000 | 287,365 | -173,963-60.54% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #49 | $302,261 | 106,806 | $127,334 | 60,348 | +46,458+76.98% | Add |
| Man Group plc |
| <0.01% | <0.01% | #45 | $283,133 | 100,047 | $322,032 | 152,622 | -52,575-34.45% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #77 | $268,428 | 94,851 | $200,136 | 94,851 | 00.00% | Unchanged |
