| Redmile Group, LLC |
| 2.33% | 1.02% | #1 | $34.8M | 12.9M | $15.4M | 12.9M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #79 | $19.7M | 7.3M | $12.1M | 10.1M | -2.8M-27.51% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $12.3M | 4.5M | $5.0M | 4.1M | +411,308+9.95% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $12.0M | 4.4M | $5.0M | 4.2M | +253,473+6.05% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #17 | $11.7M | 4.4M | $4.9M | 4.1M | +231,050+5.61% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $10.4M | 3.8M | $3.6M | 3.0M | +835,708+27.84% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #23 | $9.7M | 3.6M | $4.2M | 3.5M | +123,077+3.55% | Add |
| JOHNSON & JOHNSON |
| 1.14% | 0.62% | #2 | $9.1M | 3.4M | $4.1M | 3.4M | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #20 | $8.1M | 3.0M | $3.6M | 3.0M | +8,585+0.29% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #36 | $6.6M | 2.4M | $0 | 0 | +2.4M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $5.5M | 2.0M | $1.6M | 1.3M | +721,430+54.33% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #90 | $3.6M | 1.3M | $3.1M | 2.6M | -1.3M-48.97% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #83 | $3.0M | 1.1M | $793,895 | 661,579 | +459,828+69.50% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #76 | $3.0M | 1.1M | $1.2M | 970,226 | +123,382+12.72% | Add |
| T. Rowe Price Investment Management, Inc. |
| <0.01% | — | #38 | $2.9M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Bruce & Co., Inc. |
| 0.75% | 0.27% | #3 | $2.7M | 989,188 | $947,026 | 789,188 | +200,000+25.34% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #110 | $1.9M | 694,580 | $1.2M | 929,944 | -235,364-25.31% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #102 | $1.8M | 672,050 | $456,595 | 380,496 | +291,554+76.62% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #74 | $1.7M | 640,428 | $784,513 | 653,761 | -13,333-2.04% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #86 | $1.6M | 610,949 | $907,528 | 756,273 | -145,324-19.22% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #88 | $1.6M | 590,178 | $2.2M | 1.8M | -1.2M-67.60% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | — | #43 | $1.6M | 578,150 | $0 | 0 | +578,150 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #31 | $1.6M | 574,995 | $563,742 | 469,785 | +105,210+22.40% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #125 | $1.5M | 558,928 | $2.7M | 2.3M | -1.7M-75.30% | Reduce |
| DAFNA Capital Management LLC |
| 0.27% | 0.15% | #4 | $1.4M | 525,000 | $660,000 | 550,000 | -25,000-4.55% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | — | #49 | $1.3M | 492,426 | $0 | 0 | +492,426 | New Buy |
| IEQ CAPITAL, LLC |
| 0.01% | <0.01% | #26 | $1.3M | 487,728 | $389,746 | 324,788 | +162,940+50.17% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #45 | $1.2M | 442,228 | $51,743 | 43,119 | +399,109+925.60% | Add |
| Privium Fund Management B.V. |
| 0.21% | 0.1% | #5 | $1.1M | 414,311 | $497,173 | 414,311 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #93 | $949,091 | 352,226 | $1.1M | 883,790 | -531,564-60.15% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #15 | $912,757 | 338,058 | $0 | 0 | +338,058 | New Buy |
| Cerity Partners LLC |
| <0.01% | <0.01% | #50 | $854,028 | 341,732 | $136,253 | 113,544 | +228,188+200.97% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #75 | $733,412 | 271,634 | $30,858 | 25,715 | +245,919+956.33% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #122 | $718,151 | 265,982 | $451,063 | 375,886 | -109,904-29.24% | Reduce |
| Headlands Technologies LLC |
| 0.07% | 0.02% | #7 | $679,865 | 251,802 | $150,850 | 125,708 | +126,094+100.31% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #107 | $663,697 | 245,814 | $0 | 0 | +245,814 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $655,212 | 242,671 | $974,305 | 811,920 | -569,249-70.11% | Reduce |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #81 | $635,511 | 240,724 | $116,244 | 97,684 | +143,040+146.43% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #105 | $550,114 | 203,746 | $195,295 | 162,746 | +41,000+25.19% | Add |
| Mariner, LLC |
| <0.01% | <0.01% | #63 | $518,762 | 192,215 | $117,911 | 98,295 | +93,920+95.55% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #112 | $507,571 | 187,989 | $87,596 | 72,996 | +114,993+157.53% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $499,500 | 185,000 | $222,000 | 185,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.01% | 0.01% | #24 | $488,230 | 180,826 | $467,003 | 389,169 | -208,343-53.54% | Reduce |
| Man Group plc |
| <0.01% | <0.01% | #55 | $475,489 | 176,107 | $516,088 | 430,073 | -253,966-59.05% | Reduce |
| Woodline Partners LP |
| <0.01% | <0.01% | #44 | $431,055 | 159,650 | $286,380 | 238,650 | -79,000-33.10% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #132 | $415,006 | 153,706 | $226,276 | 188,564 | -34,858-18.49% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | — | #66 | $414,785 | 153,624 | $0 | 0 | +153,624 | New Buy |
| Arete Wealth Advisors, LLC |
| 0.01% | — | #18 | $405,000 | 150,000 | $0 | 0 | +150,000 | New Buy |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #64 | $393,763 | 145,838 | $228,302 | 190,252 | -44,414-23.34% | Reduce |
| National Philanthropic Trust |
| <0.01% | 0.01% | #28 | $337,500 | 125,000 | $467,500 | 125,000 | 00.00% | Unchanged |
