| BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $15.7M | 3.6M | $11.5M | 3.3M | +357,816+10.92% | Add |
| Blue Water Life Science Advisors, LP |
| 9.45% | 6.05% | #1 | $15.0M | 3.5M | $7.5M | 2.1M | +1.3M+62.18% | Add |
| First Eagle Investment Management, LLC |
| 0.02% | 0.01% | #12 | $11.9M | 2.8M | $4.6M | 1.3M | +1.5M+111.77% | Add |
| Portolan Capital Management, LLC |
| 0.31% | 0.55% | #5 | $8.2M | 1.9M | $10.4M | 2.9M | -1.0M-35.53% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $7.8M | 1.8M | $6.3M | 1.8M | +16,031+0.90% | Add |
| Lionhunter Capital Management, LLC |
| 2.92% | — | #2 | $6.5M | 1.5M | $0 | 0 | +1.5M | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $5.8M | 1.3M | $296,145 | 84,132 | +1.3M+1,496.31% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #49 | $4.9M | 1.1M | $3.5M | 994,764 | +136,613+13.73% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #33 | $4.3M | 987,424 | $12.5M | 3.5M | -2.6M-72.13% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #20 | $4.2M | 973,872 | $2.2M | 622,380 | +351,492+56.48% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #72 | $4.0M | 932,307 | $3.2M | 898,277 | +34,030+3.79% | Add |
| Tikvah Management LLC |
| 0.75% | 0.62% | #4 | $2.5M | 571,555 | $2.0M | 571,619 | -64-0.01% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $2.1M | 489,566 | $2.0M | 576,600 | -87,034-15.09% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | — | #16 | $2.1M | 487,600 | $0 | 0 | +487,600 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $1.9M | 447,688 | $4.4M | 806,263 | -358,575-44.47% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #66 | $1.9M | 433,350 | $547,906 | 155,655 | +277,695+178.40% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.11% | 0.02% | #7 | $1.8M | 410,252 | $336,000 | 95,528 | +314,724+329.46% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #25 | $1.7M | 400,402 | $1.1M | 316,001 | +84,401+26.71% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #46 | $1.7M | 397,833 | $1.6M | 443,118 | -45,285-10.22% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #62 | $1.5M | 337,227 | $1.2M | 349,658 | -12,431-3.56% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #59 | $1.3M | 310,701 | $1.2M | 345,913 | -35,212-10.18% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $1.2M | 288,311 | $952,262 | 270,529 | +17,782+6.57% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #67 | $1.2M | 281,978 | $1.3M | 376,982 | -95,004-25.20% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #27 | $1.1M | 260,000 | $0 | 0 | +260,000 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #50 | $1.0M | 232,592 | $252,883 | 71,842 | +160,750+223.75% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $992,460 | 229,736 | $308,356 | 87,601 | +142,135+162.25% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #13 | $985,111 | 228,035 | $393,043 | 111,660 | +116,375+104.22% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #31 | $974,821 | 225,653 | $328,251 | 93,253 | +132,400+141.98% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #83 | $916,082 | 212,056 | $951,059 | 270,187 | -58,131-21.52% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #100 | $909,940 | 210,634 | $645,413 | 183,356 | +27,278+14.88% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #88 | $822,615 | 190,420 | $232,387 | 66,019 | +124,401+188.43% | Add |
| IRONWOOD INVESTMENT MANAGEMENT LLC |
| 0.25% | 0.25% | #6 | $736,798 | 170,555 | $597,784 | 169,825 | +730+0.43% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #92 | $695,032 | 160,887 | $409,080 | 116,216 | +44,671+38.44% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #74 | $644,362 | 149,158 | $454,165 | 129,024 | +20,134+15.60% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #15 | $642,030 | 148,618 | $0 | 0 | +148,618 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $591,304 | 136,876 | $473,099 | 134,403 | +2,473+1.84% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #81 | $569,808 | 131,900 | $444,797 | 126,363 | +5,537+4.38% | Add |
| SCS Capital Management LLC |
| <0.01% | <0.01% | #19 | $518,551 | 120,035 | $422,523 | 120,035 | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #57 | $434,000 | 100,463 | $358,371 | 101,810 | -1,347-1.32% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #99 | $413,104 | 95,626 | $241,000 | 68,372 | +27,254+39.86% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #22 | $346,464 | 80,200 | $0 | 0 | +80,200 | New Buy |
| Cerity Partners LLC |
| <0.01% | — | #42 | $337,319 | 78,083 | $0 | 0 | +78,083 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #18 | $294,736 | 68,226 | $240,156 | 68,226 | 00.00% | Unchanged |
| Clearstead Advisors, LLC |
| <0.01% | <0.01% | #24 | $268,969 | 62,261 | $436,902 | 124,120 | -61,859-49.84% | Reduce |
| Jain Global LLC |
| <0.01% | — | #32 | $247,618 | 57,319 | $0 | 0 | +57,319 | New Buy |
| ALGERT GLOBAL LLC |
| <0.01% | — | #23 | $238,537 | 55,217 | $0 | 0 | +55,217 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #60 | $231,358 | 53,557 | $183,257 | 52,065 | +1,492+2.87% | Add |
| PEDDOCK CAPITAL ADVISORS, LLC |
| 0.04% | 0.04% | #8 | $225,094 | 52,105 | $183,410 | 52,105 | 00.00% | Unchanged |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #86 | $199,866 | 56,780 | $282,893 | 44,480 | +12,300+27.65% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $175,660 | 40,662 | $2.4M | 689,167 | -648,505-94.10% | Reduce |
