| FMR LLC |
| 0.16% | 0.12% | #88 | $3.63B | 51.9M | $2.32B | 45.7M | +6.2M+13.55% | Add |
| BlackRock, Inc. |
| 0.03% | 0.03% | #211 | $2.14B | 30.6M | $1.51B | 29.6M | +963,533+3.25% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.03% | 0.03% | #193 | $1.63B | 23.2M | $1.16B | 22.9M | +336,334+1.47% | Add |
| Capital World Investors |
| 0.18% | 0.13% | #79 | $1.56B | 22.3M | $949.8M | 18.7M | +3.6M+19.14% | Add |
| BAILLIE GIFFORD & CO |
| 1.16% | 0.99% | #21 | $1.28B | 18.2M | $1.02B | 20.0M | -1.8M-8.90% | Reduce |
| STATE STREET CORP |
| 0.03% | 0.03% | #202 | $1.10B | 15.7M | $755.0M | 14.9M | +864,784+5.82% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.05% | 0.04% | #159 | $1.09B | 15.6M | $793.3M | 15.6M | -35,054-0.22% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.06% | 0.07% | #152 | $734.4M | 10.5M | $638.8M | 12.6M | -2.1M-16.61% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.03% | #188 | $678.8M | 9.7M | $478.5M | 9.4M | +275,203+2.92% | Add |
| MORGAN STANLEY |
| 0.04% | 0.02% | #190 | $668.0M | 9.5M | $257.3M | 10.0M | -424,138-4.26% | Reduce |
| Theleme Partners LLP |
| 33.52% | 27.24% | #1 | $564.3M | 8.1M | $408.9M | 8.0M | +9,326+0.12% | Add |
| JANE STREET GROUP, LLC |
| 0.04% | 0.05% | #170 | $508.8M | 7.3M | $373.6M | 7.4M | -88,588-1.20% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.37% | 0.38% | #51 | $507.2M | 7.2M | $467.7M | 9.2M | -2.0M-21.34% | Reduce |
| CITADEL ADVISORS LLC |
| 0.05% | 0.06% | #157 | $436.5M | 6.2M | $358.9M | 7.1M | -832,874-11.79% | Reduce |
| Invesco Ltd. |
| 0.03% | 0.04% | #209 | $404.8M | 5.8M | $243.1M | 4.8M | +995,541+20.81% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | <0.01% | #180 | $391.4M | 5.6M | $37.5M | 738,578 | +4.9M+656.80% | Add |
| UBS Group AG |
| 0.05% | 0.06% | #163 | $361.9M | 5.2M | $423.5M | 8.3M | -3.2M-38.01% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.05% | 0.04% | #165 | $338.9M | 4.8M | $240.5M | 4.7M | +104,528+2.21% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.03% | 0.04% | #222 | $335.9M | 4.8M | $344.0M | 6.8M | -2.0M-29.15% | Reduce |
| Flagship Pioneering, LLC |
| 21.07% | 20.26% | #3 | $324.4M | 4.6M | $235.3M | 4.6M | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.15% | 0.12% | #91 | $321.8M | 4.4M | $248.8M | 4.3M | +56,283+1.30% | Add |
| Tidal Investments LLC |
| 0.48% | 0.54% | #43 | $275.5M | 3.9M | $257.8M | 5.1M | -1.1M-22.56% | Reduce |
| NORGES BANK |
| 0.02% | 0.01% | #264 | $211.9M | 3.0M | $77.6M | 2.7M | +287,534+10.50% | Add |
| NORTHERN TRUST CORP |
| 0.02% | 0.02% | #245 | $209.1M | 3.0M | $150.0M | 3.0M | +33,288+1.13% | Add |
| D. E. Shaw & Co., Inc. |
| 0.1% | 0.16% | #114 | $200.7M | 2.9M | $271.8M | 5.4M | -2.5M-46.45% | Reduce |
| BANQUE PICTET & CIE SA |
| 1.18% | 0.98% | #19 | $189.0M | 2.7M | $139.6M | 2.7M | -49,352-1.80% | Reduce |
| CITIGROUP INC |
| 0.06% | 0.14% | #149 | $175.1M | 2.5M | $320.0M | 6.3M | -3.8M-60.31% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.02% | #213 | $172.9M | 2.5M | $108.2M | 2.1M | +336,608+15.79% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #220 | $172.4M | 2.5M | $119.8M | 2.4M | +103,977+4.41% | Add |
| LMR Partners LLP |
| 0.64% | 0.13% | #35 | $171.3M | 2.4M | $57.6M | 1.1M | +1.3M+115.69% | Add |
| Merck & Co., Inc. |
| 30.71% | 33.56% | #2 | $161.6M | 2.3M | $117.3M | 2.3M | 00.00% | Unchanged |
| BAMCO INC /NY/ |
| 0.21% | — | #70 | $139.3M | 2.0M | $0 | 0 | +2.0M | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| 0.03% | 0.03% | #216 | $139.2M | 2.0M | $99.9M | 2.0M | +21,310+1.08% | Add |
| FEDERATED HERMES, INC. |
| 0.18% | 0.16% | #81 | $125.7M | 1.8M | $100.4M | 2.0M | -182,301-9.22% | Reduce |
| Bank of New York Mellon Corp |
| 0.02% | 0.02% | #278 | $119.2M | 1.7M | $85.9M | 1.7M | +10,470+0.62% | Add |
| BARCLAYS PLC |
| 0.02% | 0.01% | #257 | $116.1M | 1.7M | $54.4M | 1.1M | +586,557+54.75% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.02% | #282 | $106.6M | 1.5M | $82.3M | 1.6M | -98,725-6.09% | Reduce |
| NATIONAL BANK OF CANADA /FI/ |
| 0.09% | 0.09% | #119 | $99.8M | 1.4M | $92.3M | 1.8M | -392,199-21.58% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #434 | $98.7M | 1.4M | $50.1M | 986,360 | +423,319+42.92% | Add |
| Douglas Lane & Associates, LLC |
| 1.28% | 0.98% | #18 | $94.1M | 1.3M | $66.6M | 1.3M | +31,999+2.44% | Add |
| Qube Research & Technologies Ltd |
| 0.09% | 0.12% | #118 | $93.4M | 1.3M | $107.0M | 2.1M | -772,235-36.67% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 1.05% | 0.99% | #24 | $70.0M | 1.0M | $50.8M | 1.0M | 00.00% | Unchanged |
| Allianz Asset Management GmbH |
| 0.06% | 0.05% | #147 | $69.0M | 989,897 | $50.2M | 988,908 | +989+0.10% | Add |
| DEUTSCHE BANK AG\ |
| 0.02% | 0.01% | #272 | $68.9M | 983,450 | $41.2M | 810,253 | +173,197+21.38% | Add |
| Affinity Asset Advisors, LLC |
| 3.09% | 2.1% | #10 | $68.3M | 975,000 | $40.6M | 800,000 | +175,000+21.88% | Add |
| ROYAL BANK OF CANADA |
| 0.01% | 0.01% | #381 | $66.1M | 944,457 | $52.7M | 1.0M | -93,383-9.00% | Reduce |
| Walleye Trading LLC |
| 0.08% | 0.1% | #129 | $65.8M | 939,266 | $58.5M | 1.2M | -212,991-18.48% | Reduce |
| Amundi |
| 0.02% | 0.01% | #332 | $62.2M | 888,779 | $46.0M | 904,823 | -16,044-1.77% | Reduce |
| Legal & General Group Plc |
| 0.01% | 0.01% | #353 | $61.8M | 883,075 | $38.1M | 750,841 | +132,234+17.61% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #521 | $59.5M | 837,452 | $63.5M | 1.3M | -480,149-36.44% | Reduce |
