| SR ONE CAPITAL MANAGEMENT, LP |
| 2.56% | — | #1 | $26.6M | 2.0M | $0 | 0 | +2.0M | New Buy |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.07% | — | #7 | $15.1M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Avidity Partners Management LP |
| 1.71% | — | #2 | $10.7M | 798,282 | $0 | 0 | +798,282 | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.09% | — | #6 | $9.0M | 670,752 | $0 | 0 | +670,752 | New Buy |
| Aberdeen Group plc |
| 0.01% | — | #10 | $7.8M | 584,570 | $0 | 0 | +584,570 | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 0.11% | — | #5 | $7.0M | 523,654 | $0 | 0 | +523,654 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #23 | $6.0M | 444,355 | $0 | 0 | +444,355 | New Buy |
| Rock Springs Capital Management LP |
| 0.27% | — | #3 | $5.6M | 418,200 | $0 | 0 | +418,200 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | — | #13 | $5.2M | 387,500 | $0 | 0 | +387,500 | New Buy |
| Integral Health Asset Management, LLC |
| 0.13% | — | #4 | $3.4M | 250,000 | $0 | 0 | +250,000 | New Buy |
| Schonfeld Strategic Advisors LLC |
| 0.01% | — | #12 | $2.4M | 177,276 | $0 | 0 | +177,276 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #31 | $2.0M | 152,828 | $0 | 0 | +152,828 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #24 | $1.7M | 125,575 | $0 | 0 | +125,575 | New Buy |
| Ghisallo Capital Management LLC |
| 0.01% | — | #11 | $1.7M | 125,000 | $0 | 0 | +125,000 | New Buy |
| Bellevue Group AG |
| 0.03% | — | #9 | $1.3M | 100,000 | $0 | 0 | +100,000 | New Buy |
| LMR Partners LLP |
| <0.01% | — | #15 | $938,000 | 70,000 | $0 | 0 | +70,000 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #18 | $911,615 | 68,031 | $0 | 0 | +68,031 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #22 | $856,809 | 63,941 | $0 | 0 | +63,941 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #26 | $670,000 | 50,000 | $0 | 0 | +50,000 | New Buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS |
| <0.01% | — | #17 | $670,000 | 50,000 | $0 | 0 | +50,000 | New Buy |
| SCS Capital Management LLC |
| 0.01% | — | #14 | $670,000 | 50,000 | $0 | 0 | +50,000 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #25 | $628,835 | 46,928 | $0 | 0 | +46,928 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | — | #20 | $626,142 | 46,727 | $0 | 0 | +46,727 | New Buy |
| Cresset Asset Management, LLC |
| <0.01% | — | #16 | $525,213 | 39,195 | $0 | 0 | +39,195 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #29 | $461,643 | 34,451 | $0 | 0 | +34,451 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | — | #28 | $341,000 | 25,454 | $0 | 0 | +25,454 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #30 | $294,720 | 21,994 | $0 | 0 | +21,994 | New Buy |
| Hudson Bay Capital Management LP |
| <0.01% | — | #19 | $194,702 | 14,530 | $0 | 0 | +14,530 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #37 | $183,379 | 13,685 | $0 | 0 | +13,685 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #36 | $157,530 | 11,756 | $0 | 0 | +11,756 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #33 | $146,301 | 10,918 | $0 | 0 | +10,918 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #27 | $134,000 | 10,000 | $0 | 0 | +10,000 | New Buy |
| UBS Group AG |
| <0.01% | — | #34 | $115,280 | 8,603 | $0 | 0 | +8,603 | New Buy |
| Legal & General Group Plc |
| <0.01% | — | #35 | $68,314 | 5,000 | $0 | 0 | +5,000 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | — | #32 | $62,015 | 4,628 | $0 | 0 | +4,628 | New Buy |
| Mowery & Schoenfeld Wealth Management, LLC |
| 0.06% | — | #8 | $43,550 | 3,250 | $0 | 0 | +3,250 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #40 | $42,183 | 3,148 | $0 | 0 | +3,148 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #38 | $18,318 | 1,367 | $0 | 0 | +1,367 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #21 | $14,874 | 1,110 | $0 | 0 | +1,110 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #39 | $12,006 | 896 | $0 | 0 | +896 | New Buy |
