| RA CAPITAL MANAGEMENT, L.P. |
| 1.55% | 2.2% | #4 | $178.6M | 8.0M | $207.8M | 8.0M | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 10.36% | 10.89% | #1 | $164.6M | 7.4M | $191.5M | 7.4M | 00.00% | Unchanged |
| Sands Capital Alternatives, LLC |
| 9.07% | 15.38% | #2 | $55.7M | 2.5M | $64.8M | 2.5M | 00.00% | Unchanged |
| Samsara BioCapital, LLC |
| 3.86% | 5.31% | #3 | $47.0M | 2.1M | $54.7M | 2.1M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #24 | $15.8M | 711,712 | $3.8M | 144,739 | +566,973+391.72% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #13 | $15.0M | 674,143 | $18.3M | 704,440 | -30,297-4.30% | Reduce |
| Vestal Point Capital, LP |
| 0.35% | 0.48% | #5 | $14.9M | 670,000 | $17.3M | 666,760 | +3,240+0.49% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #16 | $13.6M | 629,739 | $13.5M | 577,109 | +52,630+9.12% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.13% | 0.17% | #7 | $12.2M | 550,000 | $14.3M | 550,000 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #10 | $11.3M | 507,257 | $12.1M | 468,794 | +38,463+8.20% | Add |
| Aberdeen Group plc |
| 0.02% | 0.01% | #9 | $11.0M | 493,076 | $5.7M | 220,454 | +272,622+123.66% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $9.7M | 434,423 | $11.3M | 434,813 | -390-0.09% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $6.2M | 277,325 | $3.3M | 126,540 | +150,785+119.16% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #14 | $5.2M | 233,412 | $7.8M | 300,000 | -66,588-22.20% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.13% | 0.33% | #6 | $2.9M | 131,586 | $6.5M | 250,000 | -118,414-47.37% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #35 | $2.6M | 117,561 | $446,948 | 17,250 | +100,311+581.51% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #23 | $1.9M | 85,681 | $1.5M | 59,610 | +26,071+43.74% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #26 | $1.8M | 82,451 | $540,534 | 20,862 | +61,589+295.22% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $1.7M | 75,812 | $95,349 | 3,680 | +72,132+1,960.11% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #21 | $1.5M | 68,498 | $1.5M | 59,782 | +8,716+14.58% | Add |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #12 | $1.3M | 57,000 | $1.5M | 57,000 | 00.00% | Unchanged |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #15 | $1.1M | 47,580 | $1.2M | 47,580 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #28 | $1.0M | 45,668 | $1.2M | 44,477 | +1,191+2.68% | Add |
| ALPS ADVISORS INC |
| <0.01% | — | #11 | $755,326 | 33,932 | $0 | 0 | +33,932 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #33 | $532,993 | 23,944 | $0 | 0 | +23,944 | New Buy |
| Virtus Investment Advisers, LLC |
| 0.09% | — | #8 | $394,981 | 17,744 | $0 | 0 | +17,744 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #34 | $326,087 | 14,649 | $0 | 0 | +14,649 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #25 | $278,339 | 12,504 | $307,552 | 11,870 | +634+5.34% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #29 | $263,641 | 11,844 | $0 | 0 | +11,844 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #45 | $249,601 | 11,213 | $725,998 | 28,020 | -16,807-59.98% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #37 | $244,014 | 10,962 | $0 | 0 | +10,962 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #41 | $219,306 | 9,852 | $0 | 0 | +9,852 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #47 | $198,582 | 8,921 | $0 | 0 | +8,921 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #43 | $176,856 | 7,945 | $11,789 | 455 | +7,490+1,646.15% | Add |
| MetLife Investment Management, LLC |
| <0.01% | — | #17 | $155,508 | 6,986 | $0 | 0 | +6,986 | New Buy |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #31 | $120,204 | 5,400 | $0 | 0 | +5,400 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #39 | $115,529 | 5,190 | $0 | 0 | +5,190 | New Buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #32 | $113,593 | 5,103 | $0 | 0 | +5,103 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #38 | $102,997 | 4,627 | $127,659 | 4,927 | -300-6.09% | Reduce |
| Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #19 | $72,746 | 3,268 | $0 | 0 | +3,268 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #48 | $49,172 | 2,209 | $3,627 | 140 | +2,069+1,477.86% | Add |
| STRS OHIO |
| <0.01% | — | #30 | $48,972 | 2,200 | $0 | 0 | +2,200 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #44 | $44,876 | 2,016 | $0 | 0 | +2,016 | New Buy |
| FMR LLC |
| <0.01% | — | #52 | $33,323 | 1,497 | $0 | 0 | +1,497 | New Buy |
| Legal & General Group Plc |
| <0.01% | — | #49 | $24,148 | 1,087 | $0 | 0 | +1,087 | New Buy |
| Ameritas Investment Partners, Inc. |
| <0.01% | — | #18 | $22,394 | 1,006 | $0 | 0 | +1,006 | New Buy |
| Russell Investments Group, Ltd. |
| <0.01% | — | #46 | $19,722 | 886 | $0 | 0 | +886 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #20 | $16,695 | 750 | $0 | 0 | +750 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #51 | $13,000 | 589 | $2,000 | 85 | +504+592.94% | Add |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
| <0.01% | — | #50 | $3,406 | 153 | $0 | 0 | +153 | New Buy |
