| Jupiter Topco LLC |
| 0.01% | — | #24 | $30.0M | 34.2M | $0 | 0 | +34.2M | New Buy |
| BVF INC/IL |
| 0.63% | 0.81% | #3 | $24.6M | 28.2M | $25.4M | 19.5M | +8.6M+44.25% | Add |
| MAVERICK CAPITAL LTD |
| 0.15% | 0.28% | #9 | $16.6M | 19.0M | $24.7M | 19.0M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 0.24% | 0.53% | #5 | $16.1M | 18.5M | $27.1M | 20.9M | -2.4M-11.36% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $14.1M | 16.1M | $5.6M | 4.3M | +11.9M+276.83% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $9.2M | 10.5M | $13.1M | 10.1M | +422,181+4.19% | Add |
| M28 Capital Management LP |
| 17.11% | 22.35% | #1 | $8.1M | 9.2M | $12.0M | 9.2M | 00.00% | Unchanged |
| Saturn V Capital Management LP |
| 1.05% | 2.58% | #2 | $7.3M | 8.4M | $14.2M | 10.9M | -2.6M-23.35% | Reduce |
| Soleus Capital Management, L.P. |
| 0.23% | 0.41% | #6 | $6.7M | 7.7M | $10.0M | 7.7M | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #26 | $6.6M | 7.5M | $57,110 | 43,931 | +7.5M+17,067.97% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $5.0M | 5.7M | $858,139 | 780,127 | +5.0M+634.62% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $4.7M | 5.4M | $3.2M | 2.5M | +2.9M+119.48% | Add |
| Siren, L.L.C. |
| 0.09% | 0.14% | #16 | $4.4M | 5.0M | $5.2M | 4.0M | +1.0M+25.00% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.02% | 0.08% | #22 | $4.2M | 4.8M | $11.0M | 8.4M | -3.6M-43.03% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.15% | 0.29% | #7 | $3.3M | 3.8M | $5.0M | 3.8M | -15,000-0.39% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $3.3M | 3.8M | $2.2M | 1.7M | +2.1M+124.15% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | 0.01% | #29 | $3.2M | 3.7M | $4.8M | 3.7M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #70 | $3.0M | 3.5M | $9.0M | 6.9M | -3.5M-50.15% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #34 | $2.9M | 3.3M | $3.5M | 2.7M | +633,043+23.56% | Add |
| Ikarian Capital, LLC |
| 0.25% | 0.28% | #4 | $2.3M | 2.7M | $3.5M | 2.7M | 00.00% | Unchanged |
| Redmile Group, LLC |
| 0.15% | 0.23% | #8 | $2.3M | 2.6M | $3.4M | 2.6M | -50,900-1.92% | Reduce |
| 683 Capital Management, LLC |
| 0.11% | 0.17% | #12 | $2.2M | 2.5M | $3.3M | 2.5M | -32,457-1.29% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #40 | $2.0M | 2.3M | $2.6M | 2.0M | +363,815+18.47% | Add |
| Eversept Partners, LP |
| 0.1% | 0.16% | #13 | $2.0M | 2.2M | $3.0M | 2.3M | -39,334-1.73% | Reduce |
| Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #35 | $1.5M | 1.7M | $2.6M | 2.0M | -297,931-14.75% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #64 | $1.4M | 1.6M | $598,163 | 460,125 | +1.2M+249.98% | Add |
| Boxer Capital Management, LLC |
| 0.1% | 0.26% | #14 | $1.3M | 1.5M | $2.0M | 1.5M | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #56 | $1.3M | 1.5M | $1.7M | 1.3M | +140,347+10.64% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #80 | $1.2M | 1.4M | $0 | 0 | +1.4M | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $1.1M | 1.2M | $4.6M | 3.5M | -2.3M-65.67% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #74 | $920,108 | 1.1M | $3.1M | 2.4M | -1.4M-56.23% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #42 | $868,329 | 995,334 | $1.1M | 846,265 | +149,069+17.61% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #73 | $853,689 | 978,552 | $3.4M | 2.6M | -1.6M-62.53% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #61 | $687,952 | 790,749 | $761,001 | 585,385 | +205,364+35.08% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #25 | $675,792 | 774,635 | $1.0M | 774,635 | 00.00% | Unchanged |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | 0.03% | #21 | $577,586 | 662,065 | $426,000 | 327,464 | +334,601+102.18% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #78 | $481,570 | 552,260 | $799,097 | 614,690 | -62,430-10.16% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $451,833 | 517,920 | $35,340 | 27,184 | +490,736+1,805.24% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #81 | $409,781 | 469,717 | $153,416 | 118,012 | +351,705+298.02% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #86 | $396,532 | 454,530 | $494,536 | 380,412 | +74,118+19.48% | Add |
| CANTOR FITZGERALD, L. P. |
| <0.01% | — | #30 | $392,680 | 450,115 | $0 | 0 | +450,115 | New Buy |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.01% | 0.03% | #23 | $374,126 | 428,847 | $557,501 | 428,847 | 00.00% | Unchanged |
| Virtus Investment Advisers, LLC |
| 0.09% | 0.04% | #17 | $370,712 | 424,933 | $152,798 | 117,537 | +307,396+261.53% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #95 | $311,234 | 356,920 | $1.3M | 962,386 | -605,466-62.91% | Reduce |
| Birchview Capital, LP |
| 0.13% | — | #11 | $298,601 | 342,275 | $0 | 0 | +342,275 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #79 | $244,563 | 280,333 | $0 | 0 | +280,333 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #59 | $201,939 | 231,475 | $1.1M | 819,968 | -588,493-71.77% | Reduce |
| MML INVESTORS SERVICES, LLC |
| <0.01% | <0.01% | #54 | $178,350 | 204,436 | $288,506 | 221,928 | -17,492-7.88% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #105 | $154,153 | 176,700 | $1.2M | 939,152 | -762,452-81.19% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #92 | $154,001 | 176,526 | $325 | 250 | +176,276+70,510.40% | Add |
