| BlackRock, Inc. |
| <0.01% | <0.01% | #59 | $16.5M | 7.3M | $11.5M | 7.0M | +255,579+3.64% | Add |
| Opaleye Management Inc. |
| 1.39% | 1.46% | #1 | $15.3M | 6.8M | $11.1M | 6.8M | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.02% | 0.02% | #9 | $15.3M | 6.8M | $14.1M | 8.7M | -1.9M-22.01% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #24 | $12.5M | 5.5M | $6.5M | 4.0M | +1.6M+38.79% | Add |
| Telemark Asset Management, LLC |
| 0.63% | 0.58% | #4 | $8.7M | 3.8M | $6.3M | 3.8M | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #32 | $8.6M | 3.8M | $5.5M | 3.4M | +408,944+12.03% | Add |
| Nantahala Capital Management, LLC |
| 0.27% | 0.25% | #6 | $8.2M | 3.6M | $6.7M | 4.1M | -500,000-12.13% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $8.2M | 3.6M | $6.0M | 3.7M | -51,398-1.40% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $4.9M | 2.2M | $3.1M | 1.9M | +277,040+14.69% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #77 | $4.0M | 1.8M | $2.7M | 1.7M | +89,860+5.39% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #33 | $3.0M | 1.3M | $1.6M | 979,847 | +362,167+36.96% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.01% | #14 | $3.0M | 1.3M | $1.8M | 1.1M | +242,178+22.26% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $3.0M | 1.3M | $1.4M | 879,339 | +427,832+48.65% | Add |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #26 | $2.9M | 1.3M | $1.2M | 751,170 | +527,036+70.16% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $1.9M | 845,431 | $992,021 | 608,601 | +236,830+38.91% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #36 | $1.6M | 696,599 | $394,387 | 241,955 | +454,644+187.90% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #65 | $1.5M | 682,940 | $1.1M | 657,139 | +25,801+3.93% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #56 | $1.5M | 678,640 | $1.1M | 688,210 | -9,570-1.39% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #89 | $1.5M | 649,170 | $479,768 | 196,626 | +452,544+230.15% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $1.3M | 581,058 | $898,143 | 551,008 | +30,050+5.45% | Add |
| Man Group plc |
| <0.01% | — | #29 | $1.3M | 565,593 | $0 | 0 | +565,593 | New Buy |
| Post Resch Tallon Group Inc. |
| 0.88% | 0.79% | #3 | $1.3M | 563,478 | $974,941 | 571,478 | -8,000-1.40% | Reduce |
| PERKINS CAPITAL MANAGEMENT INC |
| 0.94% | 0.81% | #2 | $1.2M | 526,100 | $859,825 | 527,500 | -1,400-0.27% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #103 | $1.1M | 478,483 | $672,533 | 412,597 | +65,886+15.97% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #87 | $982,929 | 434,924 | $1.3M | 824,870 | -389,946-47.27% | Reduce |
| ALGERT GLOBAL LLC |
| 0.01% | <0.01% | #12 | $973,857 | 430,910 | $322,000 | 197,447 | +233,463+118.24% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #60 | $886,524 | 392,267 | $598,932 | 367,443 | +24,824+6.76% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $809,724 | 358,285 | $200,000 | 123,749 | +234,536+189.53% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #37 | $808,910 | 357,925 | $876,668 | 537,833 | -179,908-33.45% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #76 | $708,690 | 313,386 | $463,390 | 284,636 | +28,750+10.10% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #42 | $696,292 | 308,095 | $95,320 | 58,479 | +249,616+426.85% | Add |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.15% | 0.11% | #7 | $597,689 | 264,464 | $431,076 | 264,464 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #86 | $594,000 | 262,926 | $351,000 | 215,301 | +47,625+22.12% | Add |
| Potomac Capital Management, Inc. |
| 0.4% | 0.39% | #5 | $587,600 | 260,000 | $446,946 | 274,200 | -14,200-5.18% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $547,397 | 242,211 | $394,804 | 242,211 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.01% | <0.01% | #19 | $543,817 | 240,627 | $273,093 | 167,542 | +73,085+43.62% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #113 | $543,568 | 240,517 | $283,547 | 173,955 | +66,562+38.26% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #92 | $542,190 | 239,907 | $3.6M | 2.2M | -1.9M-89.01% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #88 | $510,849 | 226,039 | $341,720 | 209,645 | +16,394+7.82% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #96 | $468,679 | 207,380 | $515,561 | 316,295 | -108,915-34.43% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #117 | $366,732 | 162,271 | $294,907 | 180,925 | -18,654-10.31% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #93 | $350,920 | 155,274 | $252,802 | 155,093 | +181+0.12% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #70 | $334,595 | 148,051 | $0 | 0 | +148,051 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $284,552 | 125,908 | $205,230 | 125,908 | 00.00% | Unchanged |
| STRS OHIO |
| <0.01% | <0.01% | #38 | $273,460 | 121,000 | $161,533 | 99,100 | +21,900+22.10% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #122 | $273,042 | 120,815 | $1.5M | 919,964 | -799,149-86.87% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | — | #61 | $264,726 | 117,135 | $0 | 0 | +117,135 | New Buy |
| Stonepine Capital Management, LLC |
| 0.04% | 0.27% | #8 | $247,836 | 109,662 | $681,330 | 417,994 | -308,332-73.76% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #67 | $233,449 | 103,301 | $161,871 | 99,314 | +3,987+4.01% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #127 | $231,928 | 102,623 | $86,783 | 53,241 | +49,382+92.75% | Add |
