| Nantahala Capital Management, LLC |
| 1.29% | 0.96% | #5 | $38.9M | 5.6M | $26.2M | 6.4M | -774,836-12.15% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #74 | $33.6M | 4.8M | $17.6M | 4.3M | +550,445+12.83% | Add |
| BRAIDWELL LP |
| 0.81% | 0.43% | #6 | $21.9M | 3.2M | $12.8M | 3.1M | +50,000+1.61% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.4% | 0.28% | #11 | $18.3M | 2.6M | $10.8M | 2.6M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 0.26% | 0.1% | #12 | $17.1M | 2.5M | $5.3M | 1.3M | +1.2M+91.11% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #84 | $16.4M | 2.4M | $10.2M | 2.5M | -107,515-4.35% | Reduce |
| Stonepine Capital Management, LLC |
| 2.17% | 3.59% | #3 | $14.2M | 2.0M | $9.0M | 2.2M | -168,929-7.75% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $12.4M | 1.8M | $6.0M | 1.5M | +326,770+22.36% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #85 | $11.8M | 1.7M | $5.4M | 1.3M | +376,504+28.51% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #72 | $11.2M | 1.6M | $5.7M | 1.4M | +227,056+16.44% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | — | #29 | $10.5M | 1.5M | $0 | 0 | +1.5M | New Buy |
| PINNACLE ASSOCIATES LTD |
| 0.11% | 0.06% | #16 | $10.3M | 1.5M | $4.8M | 1.2M | +328,369+28.33% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.12% | 0.1% | #15 | $10.0M | 1.4M | $5.7M | 1.4M | +40,000+2.87% | Add |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.44% | 0.29% | #9 | $9.0M | 1.3M | $5.2M | 1.3M | +35,069+2.79% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #67 | $8.5M | 1.2M | $4.5M | 1.1M | +133,021+12.24% | Add |
| Assenagon Asset Management S.A. |
| 0.01% | <0.01% | #32 | $6.3M | 908,180 | $2.5M | 598,145 | +310,035+51.83% | Add |
| Soleus Capital Management, L.P. |
| 0.2% | 0.37% | #13 | $5.7M | 822,428 | $9.2M | 2.2M | -1.4M-63.37% | Reduce |
| Soviero Asset Management, LP |
| 2.25% | 1.4% | #2 | $5.3M | 770,000 | $2.8M | 680,373 | +89,627+13.17% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #69 | $5.2M | 752,679 | $3.1M | 752,881 | -202-0.03% | Reduce |
| AWH Capital, L.P. |
| 3.04% | 2.33% | #1 | $4.3M | 625,000 | $2.6M | 625,000 | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $3.8M | 545,702 | $2.0M | 477,077 | +68,625+14.38% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #75 | $3.7M | 530,843 | $2.1M | 515,516 | +15,327+2.97% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #78 | $3.6M | 519,154 | $3.2M | 787,329 | -268,175-34.06% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $3.4M | 497,018 | $1.9M | 472,343 | +24,675+5.22% | Add |
| Caption Management, LLC |
| 0.02% | 0.01% | #27 | $3.3M | 474,316 | $1.9M | 474,316 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $3.2M | 456,183 | $1.7M | 424,658 | +31,525+7.42% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #62 | $3.2M | 454,930 | $1.8M | 441,655 | +13,275+3.01% | Add |
| STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #46 | $2.9M | 423,174 | $1.9M | 458,396 | -35,222-7.68% | Reduce |
| CM Management, LLC |
| 1.76% | 1.37% | #4 | $2.8M | 400,000 | $1.6M | 400,000 | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #56 | $2.3M | 336,901 | $2.3M | 559,050 | -222,149-39.74% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #42 | $2.1M | 302,569 | $1.4M | 339,025 | -36,456-10.75% | Reduce |
| Walleye Capital LLC |
| 0.01% | — | #33 | $1.8M | 253,917 | $0 | 0 | +253,917 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #112 | $1.6M | 237,559 | $1.6M | 265,728 | -28,169-10.60% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #81 | $1.6M | 233,614 | $458,685 | 111,602 | +122,012+109.33% | Add |
| National Philanthropic Trust |
| 0.02% | — | #26 | $1.4M | 200,000 | $0 | 0 | +200,000 | New Buy |
| DIADEMA PARTNERS LP |
| 0.17% | 0.09% | #14 | $1.4M | 200,000 | $514,572 | 125,200 | +74,800+59.74% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #52 | $1.4M | 197,708 | $650,991 | 158,392 | +39,316+24.82% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #92 | $1.2M | 169,934 | $0 | 0 | +169,934 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #94 | $1.1M | 162,849 | $588,405 | 143,164 | +19,685+13.75% | Add |
| Krensavage Asset Management, LLC |
| 0.42% | 0.25% | #10 | $1.1M | 157,985 | $649,000 | 157,985 | 00.00% | Unchanged |
| KVP Capital Advisors, LP |
| 0.76% | — | #7 | $1.0M | 150,000 | $0 | 0 | +150,000 | New Buy |
| Trexquant Investment LP |
| 0.01% | 0.01% | #34 | $1.0M | 146,325 | $1.5M | 375,210 | -228,885-61.00% | Reduce |
| Potomac Capital Management, Inc. |
| 0.67% | 0.51% | #8 | $982,010 | 141,500 | $581,565 | 141,500 | 00.00% | Unchanged |
| NATIXIS |
| <0.01% | <0.01% | #38 | $981,573 | 141,437 | $581,306 | 141,437 | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #110 | $956,061 | 137,761 | $403,000 | 97,964 | +39,797+40.62% | Add |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #59 | $888,861 | 128,078 | $512,768 | 124,761 | +3,317+2.66% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #119 | $836,638 | 120,553 | $786,691 | 191,409 | -70,856-37.02% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | — | #120 | $769,542 | 110,885 | $0 | 0 | +110,885 | New Buy |
| XTX Topco Ltd |
| 0.01% | <0.01% | #31 | $739,117 | 106,501 | $284,042 | 69,110 | +37,391+54.10% | Add |
| ANGELES WEALTH MANAGEMENT, LLC |
| 0.03% | — | #22 | $732,482 | 105,545 | $0 | 0 | +105,545 | New Buy |
