| Caligan Partners LP |
| 1.17% | 1.84% | #4 | $25.0M | 6.1M | $27.6M | 6.1M | +2,056+0.03% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.04% | #20 | $24.8M | 6.0M | $27.4M | 6.0M | 00.00% | Unchanged |
| BIOS Capital Management, LP |
| 36.33% | 31.7% | #1 | $15.1M | 3.7M | $16.8M | 3.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #61 | $12.8M | 3.1M | $672,217 | 147,740 | +3.0M+2,009.44% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #26 | $12.7M | 3.1M | $12.4M | 2.7M | +369,837+13.61% | Add |
| Nantahala Capital Management, LLC |
| 0.42% | 0.28% | #7 | $12.6M | 3.1M | $7.7M | 1.7M | +1.4M+82.08% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $12.2M | 3.0M | $11.1M | 2.4M | +508,696+20.76% | Add |
| Boxer Capital Management, LLC |
| 0.87% | 1.34% | #5 | $11.6M | 2.8M | $10.2M | 2.3M | +565,000+25.11% | Add |
| Trails Edge Capital Partners, LP |
| 1.79% | 0.52% | #2 | $11.3M | 2.7M | $2.3M | 500,000 | +2.2M+448.73% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $9.5M | 2.3M | $12.0M | 2.6M | -328,331-12.48% | Reduce |
| GREAT POINT PARTNERS LLC |
| 1.53% | 0.34% | #3 | $8.1M | 2.0M | $1.5M | 324,340 | +1.6M+507.44% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #33 | $8.0M | 1.9M | $10.5M | 2.3M | -367,771-15.90% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.5% | #9 | $7.3M | 1.8M | $8.4M | 1.8M | -65,223-3.53% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #47 | $6.3M | 1.5M | $1.5M | 326,809 | +1.2M+367.32% | Add |
| Woodline Partners LP |
| 0.02% | 0.02% | #25 | $5.9M | 1.4M | $6.2M | 1.4M | +80,683+5.96% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #56 | $5.6M | 1.4M | $2.5M | 538,347 | +829,365+154.06% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.07% | 0.07% | #17 | $4.9M | 1.2M | $5.4M | 1.2M | +402+0.03% | Add |
| Opaleye Management Inc. |
| 0.42% | 0.3% | #8 | $4.6M | 1.1M | $2.3M | 1.1M | +5,000+0.45% | Add |
| SummitTX Capital, L.P. |
| 0.11% | — | #11 | $4.1M | 1.0M | $0 | 0 | +1.0M | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $3.2M | 790,136 | $909,786 | 199,953 | +590,183+295.16% | Add |
| Bleichroeder LP |
| 0.54% | 0.58% | #6 | $3.0M | 736,842 | $3.4M | 736,842 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #52 | $2.8M | 683,895 | $1.2M | 257,649 | +426,246+165.44% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #54 | $2.7M | 665,662 | $550,095 | 120,900 | +544,762+450.59% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #67 | $1.9M | 464,900 | $47,200 | 28,606 | +436,294+1,525.18% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #58 | $1.8M | 442,154 | $429,588 | 94,415 | +347,739+368.31% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #51 | $1.7M | 410,375 | $1.3M | 281,801 | +128,574+45.63% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #76 | $1.5M | 371,950 | $0 | 0 | +371,950 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #41 | $1.4M | 330,783 | $0 | 0 | +330,783 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $1.0M | 253,962 | $494,317 | 108,641 | +145,321+133.76% | Add |
| AWM Investment Company, Inc. |
| 0.08% | — | #16 | $955,945 | 232,590 | $0 | 0 | +232,590 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #73 | $861,407 | 209,588 | $916,839 | 201,503 | +8,085+4.01% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #81 | $809,247 | 196,897 | $4.1M | 904,783 | -707,886-78.24% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #69 | $678,368 | 165,053 | $159,250 | 35,000 | +130,053+371.58% | Add |
| Mink Brook Asset Management LLC |
| 0.29% | 1.5% | #10 | $662,553 | 161,205 | $2.7M | 590,552 | -429,347-72.70% | Reduce |
| XTX Topco Ltd |
| 0.01% | <0.01% | #30 | $592,230 | 144,095 | $76,003 | 16,704 | +127,391+762.64% | Add |
| Seven Fleet Capital Management LP |
| 0.1% | 0.19% | #12 | $588,293 | 143,137 | $610,801 | 134,242 | +8,895+6.63% | Add |
| Creative Planning |
| <0.01% | <0.01% | #55 | $527,584 | 128,366 | $584,065 | 128,366 | 00.00% | Unchanged |
| Texas Capital Bank Wealth Management Services Inc |
| 0.03% | 0.02% | #22 | $503,594 | 122,529 | $402,675 | 88,500 | +34,029+38.45% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #71 | $503,390 | 122,479 | $0 | 0 | +122,479 | New Buy |
| Stonepine Capital Management, LLC |
| 0.06% | 0.13% | #18 | $413,951 | 100,718 | $312,530 | 68,688 | +32,030+46.63% | Add |
| Jump Financial, LLC |
| <0.01% | — | #37 | $389,711 | 94,820 | $0 | 0 | +94,820 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #75 | $293,220 | 71,343 | $0 | 0 | +71,343 | New Buy |
| Palogic Value Management, L.P. |
| 0.09% | 0.12% | #15 | $267,512 | 65,088 | $295,750 | 65,000 | +88+0.14% | Add |
| Aureus Asset Management, LLC |
| 0.01% | — | #27 | $239,202 | 58,200 | $0 | 0 | +58,200 | New Buy |
| Regency Capital Management Inc.\DE |
| 0.09% | 0.14% | #13 | $238,380 | 58,000 | $309,400 | 68,000 | -10,000-14.71% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #95 | $226,070 | 55,005 | $304,918 | 67,015 | -12,010-17.92% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #80 | $219,113 | 53,312 | $0 | 0 | +53,312 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #92 | $218,779 | 53,231 | $0 | 0 | +53,231 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #88 | $216,321 | 52,633 | $17,222 | 3,785 | +48,848+1,290.57% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #64 | $211,512 | 51,464 | $0 | 0 | +51,464 | New Buy |
