| ORBIMED ADVISORS LLC |
| 0.99% | 0.29% | #4 | $52.6M | 4.1M | $14.5M | 2.3M | +1.9M+83.22% | Add |
| Boxer Capital Management, LLC |
| 3.02% | — | #2 | $40.1M | 3.1M | $0 | 0 | +3.1M | New Buy |
| Atlas Venture Life Science Advisors, LLC |
| 3.93% | 1.7% | #1 | $34.6M | 2.7M | $13.4M | 2.1M | +625,000+29.87% | Add |
| BVF INC/IL |
| 0.77% | — | #6 | $29.9M | 2.4M | $0 | 0 | +2.4M | New Buy |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.26% | — | #11 | $29.7M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Point72 Asset Management, L.P. |
| 0.02% | — | #17 | $14.9M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Opaleye Management Inc. |
| 1.07% | 1.06% | #3 | $11.9M | 931,000 | $8.1M | 1.3M | -325,228-25.89% | Reduce |
| Logos Global Management LP |
| 0.44% | — | #9 | $10.2M | 800,000 | $0 | 0 | +800,000 | New Buy |
| SummitTX Capital, L.P. |
| 0.24% | — | #12 | $9.3M | 733,774 | $0 | 0 | +733,774 | New Buy |
| Ikarian Capital, LLC |
| 0.85% | — | #5 | $8.0M | 630,000 | $0 | 0 | +630,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $6.6M | 518,803 | $2.0M | 306,401 | +212,402+69.32% | Add |
| Woodline Partners LP |
| 0.01% | — | #19 | $3.6M | 286,212 | $0 | 0 | +286,212 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #27 | $3.5M | 272,752 | $120,503 | 18,770 | +253,982+1,353.13% | Add |
| Sanofi |
| 0.58% | 0.47% | #8 | $3.1M | 244,083 | $1.6M | 244,083 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $2.8M | 218,234 | $1.1M | 172,586 | +45,648+26.45% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 0.75% | 0.57% | #7 | $2.8M | 216,171 | $2.0M | 315,052 | -98,881-31.39% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | — | #15 | $2.4M | 191,727 | $0 | 0 | +191,727 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $2.3M | 179,600 | $1.3M | 206,915 | -27,315-13.20% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #38 | $2.1M | 162,747 | $421,145 | 65,599 | +97,148+148.09% | Add |
| MONIMUS CAPITAL MANAGEMENT, LP |
| 0.39% | 0.24% | #10 | $1.7M | 132,036 | $862,270 | 134,310 | -2,274-1.69% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $1.6M | 122,690 | $758,740 | 118,152 | +4,538+3.84% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $1.5M | 120,663 | $99,388 | 15,481 | +105,182+679.43% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #52 | $1.5M | 118,507 | $553,063 | 86,147 | +32,360+37.56% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #29 | $854,153 | 67,045 | $336,664 | 52,440 | +14,605+27.85% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $843,605 | 66,217 | $320,968 | 49,995 | +16,222+32.45% | Add |
| Carlyle Group Inc. |
| 0.01% | 0.07% | #21 | $769,020 | 60,363 | $7.1M | 1.1M | -1.0M-94.53% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #53 | $665,206 | 52,214 | $266,520 | 41,514 | +10,700+25.77% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #31 | $631,675 | 49,582 | $271,861 | 42,346 | +7,236+17.09% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #22 | $463,685 | 36,396 | $0 | 0 | +36,396 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #20 | $440,970 | 34,613 | $80,975 | 12,613 | +22,000+174.42% | Add |
| DAFNA Capital Management LLC |
| 0.08% | — | #14 | $419,095 | 32,896 | $0 | 0 | +32,896 | New Buy |
| Knott David M Jr |
| 0.21% | — | #13 | $387,449 | 30,412 | $0 | 0 | +30,412 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.02% | 0.01% | #18 | $353,879 | 27,777 | $178,328 | 27,777 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | — | #33 | $303,085 | 23,790 | $0 | 0 | +23,790 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #47 | $301,059 | 23,631 | $160,712 | 25,033 | -1,402-5.60% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #44 | $300,511 | 23,588 | $0 | 0 | +23,588 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #51 | $297,377 | 23,342 | $0 | 0 | +23,342 | New Buy |
| MANGROVE PARTNERS IM, LLC |
| 0.02% | — | #16 | $282,191 | 22,150 | $0 | 0 | +22,150 | New Buy |
| LPL Financial LLC |
| <0.01% | — | #45 | $231,486 | 18,170 | $0 | 0 | +18,170 | New Buy |
| Cambridge Investment Research Advisors, Inc. |
| <0.01% | <0.01% | #30 | $230,352 | 18,081 | $225,000 | 35,025 | -16,944-48.38% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #32 | $203,190 | 15,949 | $0 | 0 | +15,949 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #50 | $191,202 | 15,008 | $1,733 | 270 | +14,738+5,458.52% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #35 | $157,237 | 12,342 | $0 | 0 | +12,342 | New Buy |
| ExodusPoint Capital Management, LP |
| <0.01% | — | #28 | $144,421 | 11,336 | $0 | 0 | +11,336 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #46 | $139,223 | 10,928 | $0 | 0 | +10,928 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #26 | $138,535 | 10,874 | $0 | 0 | +10,874 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #61 | $82,259 | 6,456 | $22,458 | 11,343 | -4,887-43.08% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #48 | $61,458 | 4,824 | $12,294 | 1,915 | +2,909+151.91% | Add |
| FMR LLC |
| <0.01% | <0.01% | #65 | $43,163 | 3,388 | $21,828 | 3,400 | -12-0.35% | Reduce |
| CITIGROUP INC |
| <0.01% | — | #55 | $36,793 | 2,888 | $0 | 0 | +2,888 | New Buy |
