| Artal Group S.A. |
| 45.15% | 23.89% | #1 | $420.4M | 175.2M | $241.4M | 154.7M | +20.4M+13.20% | Add |
| FMR LLC |
| 0.01% | <0.01% | #25 | $124.3M | 51.8M | $70.3M | 45.1M | +6.7M+14.93% | Add |
| Siren, L.L.C. |
| 2.15% | 1.92% | #3 | $106.3M | 44.3M | $69.1M | 44.3M | 00.00% | Unchanged |
| Sessa Capital IM, L.P. |
| 0.76% | 0.51% | #4 | $45.5M | 19.0M | $27.9M | 17.9M | +1.0M+5.85% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #56 | $41.6M | 17.3M | $5.2M | 3.3M | +14.0M+422.20% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $23.8M | 9.9M | $14.8M | 9.5M | +382,041+4.01% | Add |
| Point72 Asset Management, L.P. |
| 0.02% | 0.02% | #17 | $19.8M | 8.3M | $12.2M | 7.8M | +436,719+5.59% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #51 | $15.0M | 6.2M | $4.9M | 3.2M | +3.1M+97.04% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #69 | $11.8M | 4.9M | $1.5M | 964,038 | +4.0M+410.12% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #80 | $5.7M | 2.4M | $852,696 | 546,600 | +1.8M+331.35% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #60 | $4.8M | 2.0M | $2.6M | 1.7M | +301,081+17.84% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #58 | $4.7M | 2.0M | $771,679 | 494,666 | +1.5M+297.97% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #54 | $4.7M | 2.0M | $2.0M | 1.3M | +645,477+49.22% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $3.9M | 1.6M | $2.1M | 1.3M | +302,287+22.69% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #79 | $3.3M | 1.4M | $4.3M | 2.8M | -1.4M-50.00% | Reduce |
| Ishara Investments LP |
| 2.21% | 1.33% | #2 | $3.1M | 1.3M | $1.4M | 902,000 | +369,000+40.91% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $2.7M | 1.1M | $7.7M | 4.9M | -3.8M-77.06% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #26 | $2.7M | 1.1M | $2.5M | 1.6M | -473,500-29.58% | Reduce |
| MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #31 | $2.3M | 963,354 | $1.2M | 772,677 | +190,677+24.68% | Add |
| ADAR1 Capital Management, LLC |
| 0.08% | 0.07% | #6 | $1.8M | 750,000 | $1.2M | 750,000 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $1.7M | 696,617 | $693,000 | 445,288 | +251,329+56.44% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #84 | $1.6M | 684,713 | $3.9M | 2.5M | -1.8M-72.43% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $1.5M | 643,444 | $1.9M | 1.2M | -556,188-46.36% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #72 | $1.4M | 586,664 | $0 | 0 | +586,664 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #94 | $1.4M | 582,900 | $5.1M | 3.2M | -2.7M-82.00% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #82 | $1.4M | 568,706 | $42,835 | 27,459 | +541,247+1,971.11% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #98 | $1.2M | 508,071 | $799,385 | 512,426 | -4,355-0.85% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #96 | $1.2M | 485,546 | $1.7M | 1.1M | -584,971-54.64% | Reduce |
| Compagnie Lombard Odier SCmA |
| 0.01% | 0.01% | #21 | $1.2M | 480,000 | $795,600 | 510,000 | -30,000-5.88% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $1.0M | 421,299 | $820,720 | 526,103 | -104,804-19.92% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| 0.06% | 0.09% | #8 | $953,326 | 397,219 | $1.5M | 930,089 | -532,870-57.29% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #88 | $929,960 | 387,483 | $164,560 | 105,487 | +281,996+267.33% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #23 | $858,905 | 357,877 | $490,798 | 314,614 | +43,263+13.75% | Add |
| Janney Montgomery Scott LLC |
| <0.01% | — | #38 | $709,315 | 295,548 | $0 | 0 | +295,548 | New Buy |
| CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | — | #71 | $618,960 | 257,900 | $0 | 0 | +257,900 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #63 | $616,523 | 256,885 | $0 | 0 | +256,885 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #89 | $594,068 | 247,528 | $0 | 0 | +247,528 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #100 | $553,128 | 230,470 | $12,105 | 7,760 | +222,710+2,869.97% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #110 | $490,538 | 204,391 | $0 | 0 | +204,391 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #103 | $431,280 | 179,700 | $0 | 0 | +179,700 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #91 | $420,492 | 175,205 | $259,581 | 166,398 | +8,807+5.29% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #57 | $420,031 | 175,013 | $288,609 | 185,006 | -9,993-5.40% | Reduce |
| Virtus Investment Advisers, LLC |
| 0.1% | — | #5 | $408,996 | 170,415 | $0 | 0 | +170,415 | New Buy |
| Headlands Technologies LLC |
| 0.04% | 0.03% | #10 | $401,275 | 167,198 | $298,462 | 191,322 | -24,124-12.61% | Reduce |
| Ikarian Capital, LLC |
| 0.04% | 0.02% | #11 | $395,218 | 164,674 | $256,892 | 164,674 | 00.00% | Unchanged |
| Quarry LP |
| 0.03% | 0.03% | #14 | $374,846 | 156,186 | $171,600 | 110,000 | +46,186+41.99% | Add |
| MetLife Investment Management, LLC |
| <0.01% | — | #34 | $351,384 | 146,410 | $0 | 0 | +146,410 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #130 | $318,964 | 132,902 | $228,175 | 169,018 | -36,116-21.37% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | — | #47 | $316,901 | 132,042 | $0 | 0 | +132,042 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #131 | $289,975 | 109,839 | $0 | 0 | +109,839 | New Buy |
