| Cormorant Asset Management, LP |
| 2.32% | 1.01% | #3 | $45.7M | 4.0M | $20.1M | 2.9M | +1.1M+37.28% | Add |
| Venrock Adviser, LLC |
| 1.12% | 0.83% | #5 | $36.9M | 3.2M | $22.2M | 3.2M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.01% | #20 | $35.2M | 3.1M | $6.1M | 877,846 | +2.2M+248.77% | Add |
| Point72 Asset Management, L.P. |
| 0.03% | — | #25 | $24.6M | 2.1M | $0 | 0 | +2.1M | New Buy |
| MPM BioImpact LLC |
| 1.36% | — | #4 | $22.3M | 1.9M | $0 | 0 | +1.9M | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 0.31% | — | #12 | $20.6M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Casdin Capital, LLC |
| 0.72% | 0.28% | #7 | $14.4M | 1.3M | $3.7M | 538,461 | +711,539+132.14% | Add |
| ADAR1 Capital Management, LLC |
| 0.54% | 0.05% | #9 | $11.7M | 1.0M | $815,930 | 117,909 | +899,896+763.21% | Add |
| Octagon Capital Advisors LP |
| 0.97% | — | #6 | $10.7M | 934,716 | $0 | 0 | +934,716 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $9.3M | 807,832 | $4.7M | 681,775 | +126,057+18.49% | Add |
| BRAIDWELL LP |
| 0.34% | — | #11 | $9.1M | 795,214 | $0 | 0 | +795,214 | New Buy |
| Squadron Capital Management LLC |
| 2.73% | 3.21% | #2 | $8.8M | 764,876 | $8.8M | 1.3M | -500,355-39.55% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.11% | — | #16 | $8.3M | 718,747 | $0 | 0 | +718,747 | New Buy |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 4.01% | 2.05% | #1 | $6.4M | 552,501 | $2.9M | 414,852 | +137,649+33.18% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #28 | $6.2M | 538,461 | $3.7M | 538,461 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.02% | 0.01% | #26 | $5.2M | 455,733 | $1.4M | 209,259 | +246,474+117.78% | Add |
| Soleus Capital Management, L.P. |
| 0.16% | — | #15 | $4.7M | 405,523 | $0 | 0 | +405,523 | New Buy |
| Freestone Grove Partners LP |
| 0.03% | — | #24 | $4.6M | 397,446 | $0 | 0 | +397,446 | New Buy |
| BOONE CAPITAL MANAGEMENT LLC |
| 0.7% | — | #8 | $3.0M | 258,390 | $0 | 0 | +258,390 | New Buy |
| DAFNA Capital Management LLC |
| 0.53% | — | #10 | $2.8M | 239,553 | $0 | 0 | +239,553 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.08% | 0.06% | #18 | $1.8M | 153,847 | $1.1M | 164,748 | -10,901-6.62% | Reduce |
| Seven Fleet Capital Management LP |
| 0.21% | — | #13 | $1.3M | 113,207 | $0 | 0 | +113,207 | New Buy |
| DV Trading LLC |
| 0.04% | — | #21 | $1.3M | 113,207 | $0 | 0 | +113,207 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $1.1M | 94,100 | $456,720 | 66,000 | +28,100+42.58% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #35 | $997,050 | 86,700 | $831,479 | 120,156 | -33,456-27.84% | Reduce |
| XTX Topco Ltd |
| 0.01% | — | #27 | $781,437 | 67,951 | $0 | 0 | +67,951 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #36 | $608,293 | 52,895 | $846,046 | 122,261 | -69,366-56.74% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | — | #32 | $547,355 | 47,596 | $0 | 0 | +47,596 | New Buy |
| Tidal Investments LLC |
| <0.01% | <0.01% | #31 | $510,071 | 44,354 | $456,955 | 66,034 | -21,680-32.83% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #37 | $408,320 | 35,506 | $0 | 0 | +35,506 | New Buy |
| Ikarian Capital, LLC |
| 0.04% | 0.02% | #23 | $389,839 | 33,899 | $234,581 | 33,899 | 00.00% | Unchanged |
| Virtus Investment Advisers, LLC |
| 0.08% | — | #17 | $364,608 | 31,705 | $0 | 0 | +31,705 | New Buy |
| ACT CAPITAL MANAGEMENT, LLC |
| 0.2% | — | #14 | $310,500 | 27,000 | $0 | 0 | +27,000 | New Buy |
| Stonepine Capital Management, LLC |
| 0.04% | — | #22 | $278,956 | 24,257 | $0 | 0 | +24,257 | New Buy |
| Verition Fund Management LLC |
| <0.01% | — | #34 | $202,331 | 17,594 | $0 | 0 | +17,594 | New Buy |
| SmartHarvest Portfolios, LLC |
| 0.05% | 0.05% | #19 | $166,072 | 14,441 | $113,260 | 16,367 | -1,926-11.77% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $163,001 | 14,174 | $77,040 | 11,133 | +3,041+27.32% | Add |
| ANTIPODES PARTNERS Ltd |
| <0.01% | <0.01% | #33 | $18,883 | 1,642 | $14,193 | 2,051 | -409-19.94% | Reduce |
| Mirae Asset Global Investments Co., Ltd. |
| <0.01% | — | #39 | $6,636 | 577 | $0 | 0 | +577 | New Buy |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #41 | $1,047 | 91 | $1,000 | 91 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #38 | $80 | 7 | $0 | 0 | +7 | New Buy |
