| RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.11% | #10 | $18.7M | 1.9M | $10.7M | 1.9M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #21 | $14.9M | 1.5M | $10.1M | 1.8M | -285,000-15.78% | Reduce |
| ACORN CAPITAL ADVISORS, LLC |
| 4.05% | 0.46% | #2 | $14.8M | 1.5M | $1.6M | 287,826 | +1.2M+427.44% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #42 | $13.9M | 1.4M | $5.3M | 947,579 | +477,079+50.35% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #61 | $13.9M | 1.4M | $1.4M | 244,899 | +1.2M+479.34% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $9.4M | 958,979 | $4.1M | 739,745 | +219,234+29.64% | Add |
| Catalio Capital Management, LP |
| 1.73% | 1.04% | #3 | $9.2M | 940,855 | $5.0M | 897,709 | +43,146+4.81% | Add |
| Avidity Partners Management LP |
| 1.45% | 0.52% | #4 | $9.0M | 924,487 | $2.6M | 463,741 | +460,746+99.35% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.01% | 0.01% | #31 | $7.7M | 786,309 | $8.6M | 1.5M | -755,781-49.01% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $6.8M | 695,264 | $842,362 | 151,232 | +544,032+359.73% | Add |
| Kalehua Capital Management LLC |
| 4.8% | — | #1 | $6.7M | 685,644 | $0 | 0 | +685,644 | New Buy |
| NEA Management Company, LLC |
| 0.35% | — | #6 | $5.6M | 576,780 | $0 | 0 | +576,780 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $5.3M | 545,700 | $7.3M | 1.3M | -769,338-58.50% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #60 | $5.2M | 531,231 | $1.1M | 206,133 | +325,098+157.71% | Add |
| Ghisallo Capital Management LLC |
| 0.03% | — | #19 | $4.9M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Soleus Capital Management, L.P. |
| 0.15% | 0.1% | #11 | $4.3M | 440,000 | $2.5M | 440,000 | 00.00% | Unchanged |
| Caption Management, LLC |
| 0.02% | 0.04% | #23 | $3.7M | 378,200 | $6.6M | 1.2M | -803,700-68.00% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #51 | $3.5M | 353,545 | $1.1M | 194,017 | +159,528+82.22% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $3.3M | 341,676 | $2.8M | 511,571 | -169,895-33.21% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #75 | $3.2M | 325,991 | $449,733 | 80,742 | +245,249+303.74% | Add |
| Affinity Asset Advisors, LLC |
| 0.14% | 0.14% | #13 | $3.1M | 312,500 | $2.8M | 500,000 | -187,500-37.50% | Reduce |
| Brevan Howard Capital Management LP |
| 0.02% | 0.01% | #22 | $3.0M | 309,817 | $1.2M | 212,367 | +97,450+45.89% | Add |
| Boxer Capital Management, LLC |
| 0.22% | 0.22% | #8 | $3.0M | 302,536 | $1.7M | 302,536 | 00.00% | Unchanged |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP |
| 0.03% | 0.02% | #17 | $2.9M | 300,000 | $1.7M | 300,000 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $2.9M | 298,997 | $1.4M | 248,957 | +50,040+20.10% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.3% | — | #7 | $2.9M | 297,460 | $0 | 0 | +297,460 | New Buy |
| Eversept Partners, LP |
| 0.14% | 0.09% | #12 | $2.7M | 276,174 | $1.7M | 299,974 | -23,800-7.93% | Reduce |
| Tetragon Partners GP Ltd |
| 0.39% | 0.11% | #5 | $2.4M | 250,300 | $573,621 | 102,984 | +147,316+143.05% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $2.1M | 207,609 | $2,496 | 471 | +207,138+43,978.34% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #73 | $2.0M | 202,506 | $168,509 | 25,766 | +176,740+685.94% | Add |
| Trexquant Investment LP |
| 0.01% | 0.01% | #27 | $1.8M | 188,368 | $1.4M | 257,903 | -69,535-26.96% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #45 | $1.8M | 188,038 | $468 | 84 | +187,954+223,754.76% | Add |
| DLD Asset Management, LP |
| 0.12% | — | #16 | $1.8M | 181,600 | $0 | 0 | +181,600 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #58 | $1.6M | 165,904 | $41,352 | 7,424 | +158,480+2,134.70% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $1.6M | 160,006 | $214,757 | 38,556 | +121,450+315.00% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $1.4M | 145,401 | $640,182 | 114,934 | +30,467+26.51% | Add |
| J. Goldman & Co LP |
| 0.03% | — | #18 | $1.3M | 135,100 | $0 | 0 | +135,100 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #83 | $1.3M | 134,818 | $0 | 0 | +134,818 | New Buy |
| SILVERBACK ASSET MANAGEMENT LLC |
| 0.14% | 0.13% | #14 | $1.3M | 130,000 | $919,050 | 165,000 | -35,000-21.21% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #44 | $1.3M | 128,451 | $715,472 | 128,451 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #67 | $1.2M | 117,969 | $2.8M | 507,500 | -389,531-76.75% | Reduce |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #39 | $1.1M | 117,600 | $1.1M | 191,527 | -73,927-38.60% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #40 | $1.1M | 108,214 | $587,156 | 105,414 | +2,800+2.66% | Add |
| C WorldWide Group Holding A/S |
| 0.02% | 0.01% | #20 | $977,000 | 100,000 | $557,000 | 100,000 | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.01% | 0.02% | #29 | $918,380 | 94,000 | $1.5M | 262,146 | -168,146-64.14% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #81 | $882,270 | 90,304 | $93,231 | 16,738 | +73,566+439.51% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #80 | $842,887 | 86,273 | $3.3M | 593,701 | -507,428-85.47% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #41 | $746,399 | 76,397 | $440,481 | 79,081 | -2,684-3.39% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #26 | $702,199 | 71,873 | $400,333 | 71,873 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | — | #47 | $623,336 | 63,801 | $0 | 0 | +63,801 | New Buy |
