| Cormorant Asset Management, LP |
| 6.92% | 8.04% | #2 | $136.2M | 17.9M | $160.0M | 17.9M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.39% | 0.52% | #12 | $37.2M | 4.9M | $43.7M | 4.9M | 00.00% | Unchanged |
| Alphabet Inc. |
| 0.59% | 0.63% | #7 | $25.3M | 2.8M | $25.3M | 2.8M | 00.00% | Unchanged |
| Omega Fund Management, LLC |
| 13.5% | 18.05% | #1 | $25.1M | 3.3M | $29.4M | 3.3M | 00.00% | Unchanged |
| EcoR1 Capital, LLC |
| 1.05% | 1.07% | #5 | $21.5M | 2.8M | $25.3M | 2.8M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #27 | $21.3M | 2.8M | $25.2M | 2.8M | -29,046-1.03% | Reduce |
| Enavate Sciences GP, LLC |
| 5.8% | 6.69% | #3 | $20.0M | 2.6M | $23.5M | 2.6M | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #30 | $19.9M | 2.6M | $22.6M | 2.5M | +89,065+3.52% | Add |
| Novo Holdings A/S |
| 1% | 1.59% | #6 | $17.1M | 2.3M | $19.6M | 2.2M | +64,077+2.93% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $16.4M | 2.2M | $18.7M | 2.1M | +65,743+3.15% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $15.3M | 2.0M | $4.8M | 538,441 | +1.5M+272.49% | Add |
| Laurion Capital Management LP |
| 0.39% | 0.75% | #11 | $15.3M | 2.0M | $17.2M | 1.9M | +80,045+4.16% | Add |
| ARMISTICE CAPITAL, LLC |
| 0.16% | 0.21% | #14 | $13.4M | 1.8M | $11.9M | 1.3M | +436,000+32.83% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #45 | $7.9M | 1.0M | $2.0M | 226,278 | +810,291+358.10% | Add |
| Aisling Capital Management LP |
| 1.64% | 1.91% | #4 | $7.8M | 1.0M | $9.1M | 1.0M | 00.00% | Unchanged |
| Opaleye Management Inc. |
| 0.48% | 0.06% | #8 | $5.3M | 700,000 | $476,874 | 53,282 | +646,718+1,213.76% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #43 | $4.7M | 622,351 | $5.2M | 579,234 | +43,117+7.44% | Add |
| Granahan Investment Management, LLC |
| 0.15% | 0.1% | #15 | $4.3M | 558,526 | $2.1M | 231,040 | +327,486+141.74% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.46% | — | #9 | $3.5M | 460,985 | $0 | 0 | +460,985 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | 0.01% | #24 | $3.0M | 400,000 | $3.6M | 400,000 | 00.00% | Unchanged |
| ROYCE & ASSOCIATES LP |
| 0.02% | 0.06% | #20 | $2.9M | 384,941 | $5.7M | 636,522 | -251,581-39.52% | Reduce |
| Catalio Capital Management, LP |
| 0.46% | — | #10 | $2.4M | 318,407 | $0 | 0 | +318,407 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #46 | $2.3M | 300,000 | $3.9M | 437,889 | -137,889-31.49% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #35 | $2.2M | 291,522 | $2.3M | 254,329 | +37,193+14.62% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #40 | $2.2M | 286,518 | $2.6M | 290,806 | -4,288-1.47% | Reduce |
| Casdin Capital, LLC |
| 0.11% | 0.19% | #17 | $2.2M | 282,312 | $2.5M | 282,312 | 00.00% | Unchanged |
| Ensign Peak Advisors, Inc |
| <0.01% | 0.01% | #28 | $2.1M | 273,530 | $2.9M | 320,874 | -47,344-14.75% | Reduce |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #31 | $1.9M | 244,441 | $2.2M | 249,161 | -4,720-1.89% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #53 | $1.8M | 240,587 | $2.2M | 240,300 | +287+0.12% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #33 | $1.5M | 191,152 | $812,830 | 90,819 | +100,333+110.48% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #48 | $1.4M | 186,482 | $915,209 | 102,258 | +84,224+82.36% | Add |
| Sio Capital Management, LLC |
| 0.16% | 0.17% | #13 | $995,385 | 130,628 | $1.2M | 130,628 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #52 | $873,671 | 114,655 | $451,528 | 50,450 | +64,205+127.26% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $803,758 | 105,480 | $2.4M | 265,954 | -160,474-60.34% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #54 | $777,888 | 102,085 | $1.5M | 167,573 | -65,488-39.08% | Reduce |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.01% | 0.02% | #22 | $762,000 | 100,000 | $895,000 | 100,000 | 00.00% | Unchanged |
| Tidal Investments LLC |
| <0.01% | <0.01% | #32 | $711,243 | 93,339 | $735,439 | 82,172 | +11,167+13.59% | Add |
| TEMA ETFS LLC |
| 0.02% | 0.05% | #21 | $711,243 | 93,339 | $735,439 | 82,172 | +11,167+13.59% | Add |
| Brevan Howard Capital Management LP |
| <0.01% | <0.01% | #25 | $690,714 | 88,895 | $127,520 | 14,248 | +74,647+523.91% | Add |
| Palumbo Wealth Management LLC |
| 0.14% | — | #16 | $652,455 | 85,624 | $0 | 0 | +85,624 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #58 | $587,807 | 77,140 | $0 | 0 | +77,140 | New Buy |
| Jump Financial, LLC |
| <0.01% | — | #26 | $472,440 | 62,000 | $0 | 0 | +62,000 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #34 | $446,532 | 58,600 | $912,005 | 101,900 | -43,300-42.49% | Reduce |
| Avidity Partners Management LP |
| 0.05% | 0.08% | #19 | $334,160 | 43,853 | $392,484 | 43,853 | 00.00% | Unchanged |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #41 | $325,603 | 42,730 | $515,269 | 57,572 | -14,842-25.78% | Reduce |
| Virtus Investment Advisers, LLC |
| 0.07% | — | #18 | $321,716 | 42,220 | $0 | 0 | +42,220 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #49 | $213,238 | 27,984 | $319,443 | 35,692 | -7,708-21.60% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #50 | $201,816 | 26,485 | $0 | 0 | +26,485 | New Buy |
| Rafferty Asset Management, LLC |
| <0.01% | — | #36 | $172,258 | 22,606 | $0 | 0 | +22,606 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #56 | $151,425 | 19,872 | $0 | 0 | +19,872 | New Buy |
