| MAK CAPITAL ONE LLC |
| 7.54% | 6.84% | #2 | $53.8M | 33.6M | $46.4M | 33.6M | 00.00% | Unchanged |
| Blackstone Inc. |
| 0.1% | 0.11% | #10 | $32.8M | 20.5M | $28.3M | 20.5M | 00.00% | Unchanged |
| Syncona Portfolio Ltd |
| 100% | 89.34% | #1 | $26.6M | 16.6M | $23.0M | 16.6M | 00.00% | Unchanged |
| ARMISTICE CAPITAL, LLC |
| 0.29% | 0.39% | #4 | $24.0M | 15.0M | $21.8M | 15.8M | -800,000-5.06% | Reduce |
| Tetragon Partners GP Ltd |
| 2.39% | 2.55% | #3 | $15.2M | 9.5M | $13.1M | 9.5M | 00.00% | Unchanged |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #18 | $12.9M | 7.8M | $12.1M | 9.5M | -1.7M-17.45% | Reduce |
| Frazier Life Sciences Management, L.P. |
| 0.15% | 0.16% | #6 | $7.1M | 4.4M | $6.1M | 4.4M | 00.00% | Unchanged |
| BNP Paribas Asset Management Holding S.A. |
| 0.01% | — | #22 | $5.4M | 3.4M | $0 | 0 | +3.4M | New Buy |
| Laurion Capital Management LP |
| 0.14% | 0.2% | #8 | $5.3M | 3.3M | $4.6M | 3.3M | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $3.2M | 2.0M | $3.2M | 2.3M | -314,799-13.69% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #51 | $2.6M | 1.6M | $2.5M | 1.8M | -239,579-12.99% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $2.6M | 1.6M | $2.0M | 1.5M | +122,726+8.29% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #40 | $2.4M | 1.5M | $1.8M | 1.3M | +211,212+16.18% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $2.0M | 1.3M | $2.0M | 1.2M | +47,059+3.88% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $2.0M | 1.2M | $282,525 | 204,728 | +1.0M+498.27% | Add |
| Cetera Investment Advisers |
| <0.01% | <0.01% | #33 | $1.9M | 1.2M | $1.6M | 1.1M | +28,250+2.50% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #31 | $1.6M | 972,748 | $1.3M | 971,691 | +1,057+0.11% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #60 | $1.5M | 913,239 | $1.2M | 935,403 | -22,164-2.37% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $1.3M | 805,790 | $808,410 | 585,804 | +219,986+37.55% | Add |
| Alphabet Inc. |
| 0.02% | 0.02% | #14 | $963,602 | 698,262 | $963,602 | 698,262 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #63 | $817,699 | 511,062 | $571,714 | 414,285 | +96,777+23.36% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.02% | 0.02% | #15 | $722,245 | 451,403 | $607,484 | 440,206 | +11,197+2.54% | Add |
| Privium Fund Management B.V. |
| 0.11% | 0.1% | #9 | $581,488 | 363,430 | $501,533 | 363,430 | 00.00% | Unchanged |
| EDENTREE ASSET MANAGEMENT Ltd |
| 0.15% | 0.12% | #7 | $477,000 | 300,000 | $414,000 | 300,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.01% | <0.01% | #20 | $459,930 | 287,456 | $77,839 | 56,405 | +231,051+409.63% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #66 | $340,147 | 212,592 | $286,842 | 207,856 | +4,736+2.28% | Add |
| Erste Asset Management GmbH |
| <0.01% | <0.01% | #29 | $321,750 | 195,000 | $247,650 | 195,000 | 00.00% | Unchanged |
| DAFNA Capital Management LLC |
| 0.05% | 0.06% | #11 | $286,906 | 179,316 | $247,456 | 179,316 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #73 | $283,572 | 177,232 | $611,261 | 442,943 | -265,711-59.99% | Reduce |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.19% | 0.19% | #5 | $240,000 | 150,000 | $207,000 | 150,000 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #77 | $198,294 | 123,934 | $152,597 | 110,578 | +13,356+12.08% | Add |
| Clearstead Advisors, LLC |
| <0.01% | <0.01% | #32 | $193,772 | 121,107 | $167,128 | 121,107 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #34 | $183,813 | 114,883 | $75,532 | 54,733 | +60,150+109.90% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $181,690 | 113,556 | $160,650 | 116,413 | -2,857-2.45% | Reduce |
| Leonteq Securities AG |
| 0.01% | 0.01% | #21 | $160,000 | 100,000 | $138,000 | 100,000 | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #56 | $151,445 | 94,654 | $36,821 | 26,682 | +67,972+254.75% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #45 | $142,981 | 89,363 | $0 | 0 | +89,363 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #80 | $135,054 | 84,409 | $115,285 | 83,540 | +869+1.04% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #54 | $113,963 | 71,227 | $589,237 | 426,983 | -355,756-83.32% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #62 | $113,440 | 70,900 | $32,624 | 23,641 | +47,259+199.90% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #78 | $106,315 | 66,447 | $73,351 | 53,153 | +13,294+25.01% | Add |
| SmartHarvest Portfolios, LLC |
| 0.03% | 0.03% | #12 | $101,763 | 63,602 | $81,675 | 59,185 | +4,417+7.46% | Add |
| HighPoint Advisor Group LLC |
| <0.01% | <0.01% | #27 | $91,200 | 57,000 | $93,530 | 47,000 | +10,000+21.28% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #76 | $68,200 | 42,625 | $51,923 | 37,625 | +5,000+13.29% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #59 | $62,720 | 39,200 | $75,210 | 54,500 | -15,300-28.07% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #69 | $62,017 | 38,764 | $48,227 | 34,951 | +3,813+10.91% | Add |
| R Squared Ltd |
| 0.03% | 0.03% | #13 | $58,282 | 36,426 | $54,614 | 39,575 | -3,149-7.96% | Reduce |
| China Universal Asset Management Co., Ltd. |
| <0.01% | <0.01% | #28 | $51,080 | 31,925 | $49,124 | 35,597 | -3,672-10.32% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $45,006 | 28,129 | $38,000 | 27,597 | +532+1.93% | Add |
| Rathbones Group PLC |
| <0.01% | <0.01% | #50 | $44,880 | 28,050 | $38,709 | 28,050 | 00.00% | Unchanged |
