| T. Rowe Price Investment Management, Inc. |
| 0.06% | 0.04% | #18 | $93.2M | 13.4M | $63.4M | 9.9M | +3.6M+36.16% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.08% | 0.05% | #16 | $56.4M | 8.1M | $29.9M | 4.6M | +3.5M+74.86% | Add |
| Redmile Group, LLC |
| 3.21% | 2.36% | #4 | $47.8M | 6.9M | $35.6M | 5.5M | +1.4M+24.41% | Add |
| ORBIMED ADVISORS LLC |
| 0.83% | 0.8% | #6 | $43.8M | 6.3M | $40.5M | 6.3M | 00.00% | Unchanged |
| Prosight Management, LP |
| 7.12% | 5.28% | #2 | $41.3M | 6.0M | $32.2M | 5.0M | +953,438+19.05% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #63 | $27.3M | 3.9M | $3.3M | 510,806 | +3.4M+670.51% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.57% | — | #7 | $26.0M | 3.8M | $0 | 0 | +3.8M | New Buy |
| NEXTBio Capital Management LP |
| 11.9% | 9.4% | #1 | $25.9M | 3.7M | $20.3M | 3.1M | +577,441+18.33% | Add |
| Deep Track Capital, LP |
| 0.37% | — | #11 | $25.7M | 3.7M | $0 | 0 | +3.7M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $22.3M | 3.2M | $14.6M | 2.3M | +930,689+40.87% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #42 | $18.3M | 2.6M | $11.5M | 1.8M | +858,288+48.14% | Add |
| PINNACLE ASSOCIATES LTD |
| 0.14% | 0.11% | #13 | $13.0M | 1.9M | $8.8M | 1.4M | +503,219+36.78% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #40 | $12.3M | 1.8M | $0 | 0 | +1.8M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #56 | $11.0M | 1.6M | $4.2M | 645,705 | +939,051+145.43% | Add |
| CLARK ESTATES INC/NY |
| 2.29% | 2.28% | #5 | $9.9M | 1.4M | $9.5M | 1.5M | -45,481-3.08% | Reduce |
| Aberdeen Group plc |
| 0.01% | 0.01% | #27 | $9.8M | 1.4M | $7.5M | 1.2M | +246,530+21.27% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | 0.01% | #28 | $8.1M | 1.2M | $6.6M | 1.0M | +139,683+13.55% | Add |
| 683 Capital Management, LLC |
| 0.39% | 0.27% | #9 | $8.0M | 1.2M | $5.1M | 800,000 | +357,216+44.65% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #71 | $7.1M | 1.0M | $1.7M | 263,768 | +762,626+289.13% | Add |
| Boxer Capital Management, LLC |
| 0.52% | — | #8 | $6.9M | 1.0M | $0 | 0 | +1.0M | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #66 | $6.6M | 946,985 | $0 | 0 | +946,985 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #31 | $5.2M | 743,761 | $3.9M | 604,500 | +139,261+23.04% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $4.1M | 593,324 | $1.2M | 191,442 | +401,882+209.92% | Add |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #37 | $3.9M | 558,876 | $2.5M | 382,648 | +176,228+46.05% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #67 | $3.7M | 533,476 | $4.6M | 715,965 | -182,489-25.49% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #62 | $3.6M | 520,316 | $810,572 | 126,061 | +394,255+312.75% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #54 | $3.2M | 463,415 | $2.1M | 324,588 | +138,827+42.77% | Add |
| S&G Foundation |
| 0.14% | 0.15% | #14 | $3.0M | 435,749 | $2.8M | 435,749 | 00.00% | Unchanged |
| ALGERT GLOBAL LLC |
| 0.03% | 0.03% | #22 | $2.9M | 421,187 | $1.8M | 286,072 | +135,115+47.23% | Add |
| FMR LLC |
| <0.01% | <0.01% | #78 | $2.7M | 392,596 | $2.5M | 392,500 | +96+0.02% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #53 | $2.5M | 356,528 | $1.3M | 194,773 | +161,755+83.05% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #36 | $2.0M | 286,489 | $895,725 | 139,304 | +147,185+105.66% | Add |
| Hillsdale Investment Management Inc. |
| 0.04% | 0.01% | #21 | $1.8M | 263,418 | $420,522 | 65,400 | +198,018+302.78% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $1.7M | 242,932 | $1.2M | 183,246 | +59,686+32.57% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #45 | $1.6M | 227,071 | $914,989 | 142,300 | +84,771+59.57% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #69 | $1.5M | 218,505 | $577,246 | 89,774 | +128,731+143.39% | Add |
| Caption Management, LLC |
| 0.01% | — | #32 | $1.4M | 200,000 | $0 | 0 | +200,000 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $1.3M | 194,008 | $4.9M | 763,745 | -569,737-74.60% | Reduce |
| West Tower Group, LLC |
| 3.73% | — | #3 | $1.3M | 191,625 | $0 | 0 | +191,625 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $1.3M | 189,899 | $262,865 | 40,881 | +149,018+364.52% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #51 | $1.3M | 185,947 | $2.0M | 316,012 | -130,065-41.16% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #82 | $1.3M | 181,712 | $39,796 | 16,651 | +165,061+991.30% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #72 | $1.1M | 155,642 | $1.0M | 155,642 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.01% | 0.02% | #30 | $650,653 | 93,754 | $916,056 | 142,466 | -48,712-34.19% | Reduce |
| Jump Financial, LLC |
| <0.01% | <0.01% | #35 | $616,272 | 88,800 | $158,730 | 24,686 | +64,114+259.72% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.08% | 0.29% | #17 | $600,039 | 86,461 | $1.8M | 280,786 | -194,325-69.21% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #75 | $565,069 | 81,422 | $0 | 0 | +81,422 | New Buy |
| Pathstone Holdings, LLC |
| <0.01% | <0.01% | #44 | $513,255 | 73,956 | $475,538 | 73,956 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #57 | $496,536 | 71,547 | $200,372 | 31,162 | +40,385+129.60% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #64 | $496,120 | 71,488 | $0 | 0 | +71,488 | New Buy |
