| FEDERATED HERMES, INC. |
| 0.06% | 0.07% | #15 | $44.8M | 2.1M | $45.7M | 1.8M | +345,000+19.54% | Add |
| ORBIMED ADVISORS LLC |
| 0.63% | 0.61% | #7 | $33.5M | 1.6M | $31.0M | 1.2M | +380,750+31.81% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.1% | 0.14% | #13 | $30.6M | 1.4M | $33.0M | 1.3M | +165,732+13.01% | Add |
| Jupiter Topco LLC |
| 0.01% | — | #23 | $29.2M | 1.4M | $0 | 0 | +1.4M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #45 | $26.0M | 1.2M | $1.7M | 65,921 | +1.2M+1,755.04% | Add |
| Affinity Asset Advisors, LLC |
| 1.1% | 1.35% | #4 | $24.3M | 1.1M | $26.2M | 1.0M | +133,501+13.19% | Add |
| MPM BioImpact LLC |
| 1.28% | 2% | #3 | $21.0M | 987,448 | $25.9M | 1.0M | -13,234-1.32% | Reduce |
| TCG Crossover Management, LLC |
| 0.47% | — | #9 | $19.6M | 920,000 | $0 | 0 | +920,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $18.3M | 861,737 | $13.8M | 531,692 | +330,045+62.07% | Add |
| Woodline Partners LP |
| 0.05% | 0.03% | #17 | $15.1M | 712,753 | $8.6M | 331,987 | +380,766+114.69% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.04% | #21 | $14.9M | 700,000 | $24.6M | 950,000 | -250,000-26.32% | Reduce |
| Integral Health Asset Management, LLC |
| 0.57% | 0.19% | #8 | $14.3M | 675,000 | $3.9M | 150,000 | +525,000+350.00% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $13.9M | 655,199 | $8.8M | 337,983 | +317,216+93.86% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #31 | $11.6M | 547,415 | $6.0M | 233,369 | +314,046+134.57% | Add |
| FMR LLC |
| <0.01% | <0.01% | #42 | $10.7M | 502,826 | $8.8M | 340,695 | +162,131+47.59% | Add |
| Cable Car Capital, LP |
| 3.37% | 3.44% | #1 | $10.4M | 400,000 | $10.4M | 400,000 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #41 | $10.1M | 473,280 | $3.3M | 125,442 | +347,838+277.29% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #29 | $8.9M | 418,891 | $2.9M | 111,788 | +307,103+274.72% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #51 | $7.0M | 328,522 | $1.4M | 54,821 | +273,701+499.26% | Add |
| Candriam S.C.A. |
| 0.03% | — | #19 | $6.4M | 303,100 | $0 | 0 | +303,100 | New Buy |
| Boxer Capital Management, LLC |
| 0.44% | — | #10 | $5.8M | 274,500 | $0 | 0 | +274,500 | New Buy |
| Trails Edge Capital Partners, LP |
| 0.92% | — | #5 | $5.8M | 273,181 | $0 | 0 | +273,181 | New Buy |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.69% | 0.76% | #6 | $5.3M | 249,693 | $4.8M | 184,984 | +64,709+34.98% | Add |
| Squadron Capital Management LLC |
| 1.48% | — | #2 | $4.8M | 225,000 | $0 | 0 | +225,000 | New Buy |
| AWM Investment Company, Inc. |
| 0.41% | 0.57% | #11 | $4.7M | 222,500 | $5.2M | 200,000 | +22,500+11.25% | Add |
| LORD, ABBETT & CO. LLC |
| 0.01% | 0.01% | #22 | $4.5M | 210,442 | $3.0M | 114,635 | +95,807+83.58% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #43 | $3.5M | 164,557 | $529,655 | 20,450 | +144,107+704.68% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $3.2M | 150,887 | $614,141 | 23,712 | +127,175+536.33% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #39 | $2.9M | 136,174 | $1.9M | 72,095 | +64,079+88.88% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #61 | $2.8M | 133,771 | $0 | 0 | +133,771 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #53 | $2.4M | 112,711 | $4.9M | 190,794 | -78,083-40.93% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #40 | $2.3M | 108,347 | $0 | 0 | +108,347 | New Buy |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #33 | $1.5M | 70,409 | $2.4M | 91,772 | -21,363-23.28% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #60 | $999,664 | 47,043 | $0 | 0 | +47,043 | New Buy |
| J. Goldman & Co LP |
| 0.03% | 0.04% | #20 | $981,368 | 46,182 | $1.4M | 54,174 | -7,992-14.75% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $956,399 | 45,007 | $2,265 | 151 | +44,856+29,705.96% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #56 | $938,315 | 44,156 | $763,817 | 29,491 | +14,665+49.73% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #58 | $869,763 | 40,930 | $0 | 0 | +40,930 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $853,400 | 40,160 | $1.4M | 53,473 | -13,313-24.90% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #36 | $826,583 | 38,898 | $484,770 | 18,717 | +20,181+107.82% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #70 | $713,299 | 33,567 | $559,595 | 21,606 | +11,961+55.36% | Add |
| MANGROVE PARTNERS IM, LLC |
| 0.05% | 0.05% | #18 | $708,603 | 33,346 | $665,785 | 25,706 | +7,640+29.72% | Add |
| ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $639,795 | 30,108 | $743,252 | 28,697 | +1,411+4.92% | Add |
| XTX Topco Ltd |
| 0.01% | — | #25 | $636,374 | 29,947 | $0 | 0 | +29,947 | New Buy |
| Trexquant Investment LP |
| <0.01% | 0.01% | #27 | $534,820 | 25,168 | $1.9M | 73,651 | -48,483-65.83% | Reduce |
| Weil Company, Inc. |
| 0.09% | 0.14% | #14 | $526,256 | 24,765 | $641,414 | 24,765 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | — | #47 | $470,662 | 22,149 | $0 | 0 | +22,149 | New Buy |
| Ikarian Capital, LLC |
| 0.05% | 0.25% | #16 | $445,655 | 20,972 | $3.1M | 118,972 | -98,000-82.37% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #72 | $442,106 | 20,805 | $1.5M | 57,933 | -37,128-64.09% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #62 | $409,509 | 19,271 | $0 | 0 | +19,271 | New Buy |
