| BlackRock, Inc. |
| 0.04% | 0.02% | #247 | $2.56B | 13.7M | $1.09B | 11.2M | +2.5M+22.15% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 11.71% | 7.54% | #13 | $2.54B | 13.6M | $1.32B | 13.6M | -54,000-0.40% | Reduce |
| FMR LLC |
| 0.1% | 0.04% | #154 | $2.28B | 12.2M | $823.2M | 8.5M | +3.7M+44.14% | Add |
| BAKER BROS. ADVISORS LP |
| 10.74% | 5.34% | #14 | $2.14B | 11.4M | $929.3M | 9.6M | +1.9M+19.76% | Add |
| Darwin Global Management, Ltd. |
| 54.45% | 5.44% | #3 | $2.05B | 10.6M | $205.0M | 2.2M | +8.4M+380.77% | Add |
| Jupiter Topco LLC |
| 0.82% | — | #72 | $2.01B | 10.7M | $0 | 0 | +10.7M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.04% | 0.02% | #253 | $1.70B | 9.1M | $813.2M | 8.4M | +726,377+8.69% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.07% | 0.04% | #181 | $1.55B | 8.3M | $729.6M | 7.5M | +792,232+10.56% | Add |
| Nextech Invest Ltd. |
| 67.81% | 52.02% | #1 | $1.42B | 7.6M | $739.2M | 7.6M | 00.00% | Unchanged |
| Paradigm Biocapital Advisors LP |
| 22.31% | 13.23% | #6 | $1.19B | 6.4M | $647.3M | 6.7M | -294,380-4.42% | Reduce |
| UBS Group AG |
| 0.13% | 0.06% | #142 | $1.02B | 5.5M | $427.3M | 4.4M | +1.1M+24.15% | Add |
| STATE STREET CORP |
| 0.03% | 0.01% | #300 | $917.1M | 4.9M | $428.2M | 4.4M | +494,389+11.23% | Add |
| Capital World Investors |
| 0.09% | — | #164 | $750.7M | 4.0M | $0 | 0 | +4.0M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.04% | 0.02% | #244 | $736.8M | 3.9M | $323.9M | 3.3M | +604,534+18.11% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.12% | 0.11% | #144 | $719.8M | 3.8M | $586.2M | 6.0M | -2.2M-36.24% | Reduce |
| JPMORGAN CHASE & CO |
| 0.04% | <0.01% | #260 | $636.9M | 3.3M | $27.9M | 301,393 | +3.0M+994.27% | Add |
| BVF INC/IL |
| 14.2% | 8.85% | #11 | $555.3M | 3.0M | $277.8M | 2.9M | +108,378+3.79% | Add |
| Casdin Capital, LLC |
| 24.16% | 18.98% | #5 | $482.7M | 2.6M | $250.6M | 2.6M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 4.67% | 2.64% | #29 | $448.0M | 2.4M | $223.4M | 2.3M | +95,000+4.14% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | 0.04% | #226 | $447.7M | 2.4M | $314.3M | 3.2M | -841,910-26.05% | Reduce |
| Avoro Capital Advisors LLC |
| 3.86% | 2.24% | #32 | $430.2M | 2.3M | $228.0M | 2.3M | -47,444-2.02% | Reduce |
| Caligan Partners LP |
| 19.5% | 12.18% | #9 | $414.6M | 2.2M | $183.0M | 1.9M | +331,887+17.64% | Add |
| NORGES BANK |
| 0.04% | 0.01% | #239 | $404.1M | 2.2M | $49.6M | 1.4M | +753,951+53.72% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.03% | 0.02% | #261 | $399.5M | 2.1M | $212.5M | 2.2M | -52,399-2.40% | Reduce |
| Nearwater Capital Markets, Ltd |
| 6.77% | 1.56% | #22 | $392.7M | 2.1M | $65.9M | 678,000 | +1.4M+209.29% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.12% | — | #145 | $376.8M | 2.0M | $0 | 0 | +2.0M | New Buy |
| Woodline Partners LP |
| 1.16% | 0.92% | #66 | $375.1M | 2.0M | $243.8M | 2.5M | -503,707-20.10% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.05% | 0.03% | #217 | $359.0M | 1.9M | $168.8M | 1.7M | +181,549+10.46% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.03% | 0.02% | #299 | $351.3M | 1.9M | $216.8M | 2.2M | -353,200-15.85% | Reduce |
| Integral Health Asset Management, LLC |
| 13.32% | 12.79% | #12 | $337.1M | 1.8M | $267.4M | 2.8M | -950,000-34.55% | Reduce |
| Alphabet Inc. |
| 7.47% | 7.97% | #19 | $320.2M | 3.3M | $320.2M | 3.3M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| 0.06% | 0.02% | #195 | $278.7M | 1.5M | $110.2M | 1.1M | +354,848+31.30% | Add |
| Holocene Advisors, LP |
| 0.57% | 0.58% | #83 | $254.6M | 1.4M | $240.1M | 2.5M | -1.1M-44.94% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.08% | 0.01% | #166 | $242.6M | 1.3M | $11.4M | 116,787 | +1.2M+1,009.24% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.05% | 0.03% | #201 | $241.8M | 1.3M | $110.2M | 1.1M | +157,822+13.93% | Add |
| CITADEL ADVISORS LLC |
| 0.03% | 0.02% | #306 | $227.1M | 1.2M | $97.7M | 1.0M | +207,953+20.70% | Add |
| NORTHERN TRUST CORP |
| 0.02% | 0.01% | #314 | $209.2M | 1.1M | $92.8M | 954,256 | +162,854+17.07% | Add |
| Rock Springs Capital Management LP |
| 10.1% | 6.93% | #15 | $207.0M | 1.1M | $117.6M | 1.2M | -104,255-8.62% | Reduce |
| NATIONAL BANK OF CANADA /FI/ |
| 0.18% | 0.17% | #122 | $205.3M | 1.1M | $170.1M | 1.7M | -652,975-37.33% | Reduce |
| Bellevue Group AG |
| 4.13% | 3.57% | #31 | $196.3M | 1.0M | $150.2M | 1.5M | -496,442-32.14% | Reduce |
| AMERIPRISE FINANCIAL INC |
| 0.04% | 0.04% | #242 | $194.7M | 1.0M | $153.6M | 1.6M | -540,091-34.19% | Reduce |
| Pictet Asset Management Holding SA |
| 0.18% | 0.06% | #120 | $190.8M | 1.0M | $53.6M | 557,560 | +457,334+82.02% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #391 | $184.3M | 983,911 | $59.7M | 614,157 | +369,754+60.21% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.03% | 0.01% | #279 | $170.9M | 912,335 | $48.7M | 500,595 | +411,740+82.25% | Add |
| Siren, L.L.C. |
| 3.41% | 3% | #38 | $168.6M | 900,000 | $108.0M | 1.1M | -210,980-18.99% | Reduce |
| DEUTSCHE BANK AG\ |
| 0.05% | 0.01% | #215 | $166.3M | 888,019 | $45.3M | 465,758 | +422,261+90.66% | Add |
| Caption Management, LLC |
| 0.77% | 0.88% | #76 | $164.2M | 877,000 | $150.7M | 1.6M | -673,000-43.42% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #428 | $157.0M | 838,249 | $67.0M | 1.4M | -596,393-41.57% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.42% | 0.04% | #94 | $147.8M | 789,241 | $13.1M | 134,233 | +655,008+487.96% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.02% | #307 | $143.1M | 763,434 | $82.1M | 844,614 | -81,180-9.61% | Reduce |
