| FMR LLC |
| <0.01% | <0.01% | #34 | $48.4M | 9.7M | $51.1M | 9.7M | +6,672+0.07% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #56 | $21.8M | 4.4M | $7.9M | 1.5M | +2.9M+190.20% | Add |
| Sanofi |
| 2.53% | 4.25% | #1 | $13.5M | 2.7M | $14.3M | 2.7M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #65 | $11.4M | 2.3M | $0 | 0 | +2.3M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #43 | $9.7M | 1.9M | $9.6M | 1.8M | +106,888+5.84% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $6.8M | 1.4M | $3.4M | 637,944 | +732,806+114.87% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #70 | $5.0M | 1.0M | $1.4M | 268,520 | +733,475+273.15% | Add |
| DCF Advisers, LLC |
| 0.7% | 0.2% | #3 | $3.9M | 790,000 | $745,505 | 141,462 | +648,538+458.45% | Add |
| MARSHALL WACE, LLP |
| <0.01% | 0.01% | #30 | $3.7M | 731,897 | $10.5M | 2.0M | -1.3M-63.34% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | <0.01% | #25 | $3.0M | 601,255 | $2.1M | 400,363 | +200,892+50.18% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $2.6M | 521,411 | $2.8M | 529,078 | -7,667-1.45% | Reduce |
| ALETHEA CAPITAL MANAGEMENT, LLC |
| 0.98% | 0.06% | #2 | $2.4M | 472,935 | $120,867 | 22,935 | +450,000+1,962.07% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #68 | $2.3M | 460,653 | $1.7M | 325,907 | +134,746+41.34% | Add |
| Summit Financial, LLC |
| 0.02% | 0.03% | #17 | $2.3M | 452,264 | $2.0M | 376,749 | +75,515+20.04% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #61 | $2.2M | 448,857 | $2.0M | 376,284 | +72,573+19.29% | Add |
| Nuveen, LLC |
| <0.01% | — | #49 | $2.2M | 438,362 | $0 | 0 | +438,362 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $2.2M | 436,992 | $620,100 | 117,666 | +319,326+271.38% | Add |
| LEVIN CAPITAL STRATEGIES, L.P. |
| 0.14% | <0.01% | #6 | $2.1M | 414,000 | $52,700 | 10,000 | +404,000+4,040.00% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #53 | $1.8M | 360,764 | $0 | 0 | +360,764 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #84 | $1.8M | 359,085 | $0 | 0 | +359,085 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.11% | 0.03% | #9 | $1.7M | 343,303 | $404,000 | 76,752 | +266,551+347.29% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $1.6M | 330,402 | $5.8M | 1.1M | -772,310-70.04% | Reduce |
| Burkehill Global Management, LP |
| 0.05% | 0.08% | #12 | $1.5M | 300,000 | $1.6M | 300,000 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #42 | $1.4M | 288,420 | $1.3M | 244,771 | +43,649+17.83% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #91 | $1.1M | 226,491 | $2.1M | 294,857 | -68,366-23.19% | Reduce |
| Occam Crest Management LP |
| 0.62% | 1.74% | #4 | $1.1M | 278,498 | $2.9M | 545,098 | -266,600-48.91% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #83 | $1.1M | 212,600 | $707,834 | 134,314 | +78,286+58.29% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #52 | $1.0M | 203,663 | $0 | 0 | +203,663 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #77 | $837,826 | 167,901 | $196,803 | 37,344 | +130,557+349.61% | Add |
| Permanent Capital Management, LP |
| 0.1% | — | #10 | $748,500 | 150,000 | $0 | 0 | +150,000 | New Buy |
| PVG ASSET MANAGEMENT CORP |
| 0.42% | 0.36% | #5 | $730,790 | 146,451 | $614,510 | 146,661 | -210-0.14% | Reduce |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #45 | $715,995 | 143,486 | $691,877 | 131,286 | +12,200+9.29% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #78 | $658,699 | 132,004 | $0 | 0 | +132,004 | New Buy |
| Kingsview Wealth Management, LLC |
| 0.01% | 0.01% | #21 | $643,994 | 122,200 | $643,994 | 122,200 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $578,066 | 115,845 | $794,963 | 150,847 | -35,002-23.20% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #23 | $539,664 | 108,149 | $622,645 | 118,149 | -10,000-8.46% | Reduce |
| ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #76 | $527,987 | 105,809 | $115,218 | 21,863 | +83,946+383.96% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #98 | $480,138 | 96,220 | $1.7M | 327,655 | -231,435-70.63% | Reduce |
| Fisher Asset Management, LLC |
| <0.01% | — | #75 | $440,781 | 88,333 | $0 | 0 | +88,333 | New Buy |
| Corient Private Wealth LLC |
| <0.01% | — | #60 | $384,679 | 77,090 | $0 | 0 | +77,090 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #88 | $356,555 | 71,454 | $0 | 0 | +71,454 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #67 | $349,300 | 70,000 | $47,124 | 8,942 | +61,058+682.82% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #64 | $328,903 | 65,914 | $0 | 0 | +65,914 | New Buy |
| ALPS ADVISORS INC |
| <0.01% | — | #40 | $327,633 | 65,658 | $0 | 0 | +65,658 | New Buy |
| TD ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #62 | $325,328 | 65,196 | $497,172 | 94,340 | -29,144-30.89% | Reduce |
| XTX Topco Ltd |
| <0.01% | — | #26 | $321,331 | 64,395 | $0 | 0 | +64,395 | New Buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| <0.01% | <0.01% | #66 | $310,084 | 62,141 | $367,519 | 69,738 | -7,597-10.89% | Reduce |
| Clearstead Advisors, LLC |
| <0.01% | <0.01% | #31 | $303,716 | 60,865 | $320,759 | 60,865 | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #74 | $297,194 | 59,558 | $180,360 | 34,224 | +25,334+74.02% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #57 | $287,868 | 57,689 | $1.2M | 226,046 | -168,357-74.48% | Reduce |
