| PERCEPTIVE ADVISORS LLC |
| 0.65% | 0.35% | #9 | $43.3M | 1.3M | $17.8M | 715,307 | +589,539+82.42% | Add |
| BVF INC/IL |
| 1.06% | 0.99% | #8 | $41.6M | 1.3M | $31.2M | 1.3M | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 1.76% | 1.38% | #5 | $38.9M | 1.2M | $26.6M | 1.1M | +102,968+9.63% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $37.3M | 1.1M | $5.8M | 232,684 | +889,971+382.48% | Add |
| Samsara BioCapital, LLC |
| 2.9% | 2.57% | #4 | $35.3M | 1.1M | $26.5M | 1.1M | 00.00% | Unchanged |
| Kynam Capital Management, LP |
| 1.6% | 1.34% | #7 | $29.0M | 872,558 | $21.7M | 872,558 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.47% | 0.4% | #12 | $24.7M | 743,944 | $20.0M | 801,144 | -57,200-7.14% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #23 | $23.6M | 711,162 | $11.6M | 465,792 | +245,370+52.68% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $23.0M | 694,219 | $17.9M | 720,442 | -26,223-3.64% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.26% | 0.29% | #14 | $19.4M | 585,262 | $17.8M | 715,307 | -130,045-18.18% | Reduce |
| Velan Capital Investment Management LP |
| 10.36% | 7.99% | #1 | $17.0M | 512,160 | $12.8M | 512,160 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.05% | 0.04% | #19 | $15.2M | 458,029 | $11.4M | 457,441 | +588+0.13% | Add |
| ADAR1 Capital Management, LLC |
| 0.62% | 0.77% | #11 | $13.4M | 404,014 | $13.1M | 524,441 | -120,427-22.96% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $12.9M | 389,692 | $4.3M | 171,386 | +218,306+127.38% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #26 | $12.4M | 373,839 | $8.4M | 335,813 | +38,026+11.32% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $12.2M | 365,972 | $5.2M | 210,378 | +155,594+73.96% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #63 | $10.2M | 305,979 | $1.3M | 52,118 | +253,861+487.09% | Add |
| Merck & Co., Inc. |
| 1.72% | 1.94% | #6 | $9.0M | 272,351 | $6.8M | 272,351 | 00.00% | Unchanged |
| ACUTA CAPITAL PARTNERS, LLC |
| 6.25% | 4.73% | #2 | $9.0M | 270,251 | $6.7M | 269,425 | +826+0.31% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #40 | $8.1M | 244,669 | $0 | 0 | +244,669 | New Buy |
| Point72 Asset Management, L.P. |
| 0.01% | 0.02% | #28 | $7.9M | 237,827 | $17.2M | 692,111 | -454,284-65.64% | Reduce |
| KVP Capital Advisors, LP |
| 5.52% | 4.22% | #3 | $7.5M | 226,575 | $5.6M | 226,575 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #46 | $6.9M | 208,512 | $9.8M | 392,871 | -184,359-46.93% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $6.7M | 201,688 | $1.6M | 65,176 | +136,512+209.45% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #64 | $6.6M | 197,562 | $0 | 0 | +197,562 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | 0.01% | #34 | $5.8M | 175,246 | $5.5M | 222,634 | -47,388-21.29% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #42 | $5.6M | 167,997 | $0 | 0 | +167,997 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #65 | $5.3M | 159,627 | $0 | 0 | +159,627 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $5.0M | 149,216 | $677,228 | 27,187 | +122,029+448.85% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #54 | $4.2M | 125,933 | $826,165 | 33,166 | +92,767+279.71% | Add |
| Seven Fleet Capital Management LP |
| 0.63% | — | #10 | $3.8M | 159,118 | $0 | 0 | +159,118 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | — | #37 | $3.5M | 106,610 | $0 | 0 | +106,610 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #47 | $3.5M | 104,232 | $2.4M | 94,838 | +9,394+9.91% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $3.4M | 101,965 | $3.5M | 142,337 | -40,372-28.36% | Reduce |
| MACKENZIE FINANCIAL CORP |
| <0.01% | — | #38 | $3.1M | 94,767 | $0 | 0 | +94,767 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #36 | $2.9M | 86,324 | $2.4M | 97,824 | -11,500-11.76% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #75 | $1.9M | 57,305 | $427,580 | 17,165 | +40,140+233.85% | Add |
| Y-Intercept (Hong Kong) Ltd |
| 0.04% | — | #22 | $1.9M | 55,879 | $0 | 0 | +55,879 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | — | #39 | $1.8M | 55,539 | $0 | 0 | +55,539 | New Buy |
| XTX Topco Ltd |
| 0.02% | <0.01% | #24 | $1.7M | 52,169 | $204,337 | 8,203 | +43,966+535.97% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $1.6M | 49,302 | $263,473 | 10,577 | +38,725+366.12% | Add |
| Sigma Planning Corp |
| 0.04% | 0.01% | #21 | $1.5M | 45,020 | $311,873 | 12,520 | +32,500+259.58% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #72 | $1.4M | 41,369 | $0 | 0 | +41,369 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #71 | $1.2M | 36,954 | $3,462 | 139 | +36,815+26,485.61% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #82 | $1.2M | 36,140 | $470,126 | 18,873 | +17,267+91.49% | Add |
| Fisher Asset Management, LLC |
| <0.01% | <0.01% | #62 | $1.2M | 35,295 | $879,198 | 35,295 | 00.00% | Unchanged |
| Elmind Capital, LP |
| 0.27% | — | #13 | $1.1M | 32,037 | $0 | 0 | +32,037 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #81 | $1.0M | 30,526 | $3.0M | 121,502 | -90,976-74.88% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | — | #55 | $1.0M | 30,128 | $0 | 0 | +30,128 | New Buy |
| Trexquant Investment LP |
| 0.01% | 0.01% | #31 | $917,515 | 27,636 | $855,484 | 34,343 | -6,707-19.53% | Reduce |
