| Frazier Life Sciences Management, L.P. |
| 1.08% | — | #6 | $49.7M | 7.6M | $0 | 0 | +7.6M | New Buy |
| TPG GP A, LLC |
| 0.9% | — | #8 | $44.9M | 6.9M | $0 | 0 | +6.9M | New Buy |
| venBio Partners LLC |
| 7.44% | — | #2 | $38.6M | 5.9M | $0 | 0 | +5.9M | New Buy |
| Logos Global Management LP |
| 1.53% | — | #5 | $35.4M | 5.4M | $0 | 0 | +5.4M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #65 | $34.4M | 5.3M | $1.3M | 439,360 | +4.8M+1,099.93% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #38 | $32.3M | 5.0M | $12.8M | 4.4M | +584,027+13.37% | Add |
| Paradigm Biocapital Advisors LP |
| 0.61% | — | #9 | $32.3M | 5.0M | $0 | 0 | +5.0M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $27.0M | 4.1M | $6.5M | 2.2M | +1.9M+87.82% | Add |
| Propel Bio Management, LLC |
| 13.79% | 7.17% | #1 | $26.3M | 4.0M | $11.4M | 3.8M | +247,593+6.54% | Add |
| MARSHALL WACE, LLP |
| 0.02% | <0.01% | #28 | $24.6M | 3.8M | $3.0M | 1.0M | +2.8M+269.90% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #62 | $19.2M | 2.9M | $748,104 | 254,457 | +2.7M+1,057.57% | Add |
| Venrock Adviser, LLC |
| 0.54% | — | #10 | $18.0M | 2.8M | $0 | 0 | +2.8M | New Buy |
| Vivo Capital, LLC |
| 1.64% | — | #4 | $18.0M | 2.8M | $0 | 0 | +2.8M | New Buy |
| Jupiter Topco LLC |
| 0.01% | — | #37 | $18.0M | 2.8M | $0 | 0 | +2.8M | New Buy |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.19% | — | #12 | $14.5M | 2.2M | $0 | 0 | +2.2M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #59 | $13.5M | 2.1M | $1.8M | 622,785 | +1.4M+231.21% | Add |
| Alyeska Investment Group, L.P. |
| 0.03% | — | #26 | $12.6M | 1.9M | $0 | 0 | +1.9M | New Buy |
| Simplify Asset Management Inc. |
| 0.13% | 0.05% | #15 | $9.4M | 1.4M | $3.5M | 1.2M | +247,593+20.90% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #48 | $9.3M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Caption Management, LLC |
| 0.04% | <0.01% | #23 | $9.2M | 1.4M | $88,606 | 30,138 | +1.4M+4,556.03% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #52 | $5.9M | 902,255 | $2.1M | 728,448 | +173,807+23.86% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $4.9M | 743,760 | $660,741 | 224,742 | +519,018+230.94% | Add |
| Spruce Street Capital LP |
| 0.94% | — | #7 | $4.8M | 736,637 | $0 | 0 | +736,637 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #69 | $4.6M | 711,572 | $1.5M | 510,883 | +200,689+39.28% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $3.9M | 593,751 | $929,560 | 316,177 | +277,574+87.79% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #56 | $3.6M | 546,318 | $1.9M | 641,925 | -95,607-14.89% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #81 | $3.5M | 537,596 | $0 | 0 | +537,596 | New Buy |
| KVP Capital Advisors, LP |
| 2.22% | 1.02% | #3 | $3.0M | 462,355 | $1.4M | 462,355 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #47 | $2.9M | 441,187 | $1.7M | 588,551 | -147,364-25.04% | Reduce |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #45 | $2.5M | 385,900 | $367,794 | 125,100 | +260,800+208.47% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #75 | $2.1M | 326,229 | $596,232 | 202,800 | +123,429+60.86% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #74 | $2.0M | 313,004 | $959,234 | 326,270 | -13,266-4.07% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #55 | $1.8M | 278,300 | $419,244 | 142,600 | +135,700+95.16% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #84 | $1.7M | 254,356 | $519,204 | 176,600 | +77,756+44.03% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #77 | $1.5M | 232,138 | $126,420 | 43,000 | +189,138+439.86% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.15% | — | #14 | $1.5M | 227,178 | $0 | 0 | +227,178 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #76 | $1.4M | 218,126 | $0 | 0 | +218,126 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #73 | $1.2M | 191,150 | $0 | 0 | +191,150 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #95 | $1.2M | 185,075 | $207,811 | 70,684 | +114,391+161.83% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #49 | $1.2M | 178,049 | $82,179 | 27,952 | +150,097+536.98% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #78 | $1.1M | 170,633 | $299,795 | 101,971 | +68,662+67.33% | Add |
| CANTOR FITZGERALD, L. P. |
| 0.01% | — | #35 | $794,250 | 121,631 | $0 | 0 | +121,631 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #68 | $791,534 | 121,215 | $747 | 254 | +120,961+47,622.44% | Add |
| Shay Capital LLC |
| 0.04% | 0.05% | #24 | $606,049 | 92,810 | $603,035 | 205,114 | -112,304-54.75% | Reduce |
| XTX Topco Ltd |
| 0.01% | <0.01% | #36 | $587,896 | 90,030 | $53,561 | 18,218 | +71,812+394.18% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #67 | $568,253 | 87,023 | $0 | 0 | +87,023 | New Buy |
| Blue Trust, Inc. |
| 0.01% | <0.01% | #40 | $560,849 | 85,888 | $252,511 | 85,888 | 00.00% | Unchanged |
| Diametric Capital, LP |
| 0.06% | 0.01% | #22 | $530,098 | 81,179 | $54,833 | 18,651 | +62,528+335.25% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #83 | $505,977 | 77,485 | $0 | 0 | +77,485 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #80 | $483,965 | 74,114 | $16,017 | 5,448 | +68,666+1,260.39% | Add |
