| Flagship Pioneering, LLC |
| 4.02% | 5.22% | #1 | $61.8M | 12.7M | $60.6M | 12.7M | 00.00% | Unchanged |
| BVF INC/IL |
| 0.73% | 0.89% | #3 | $28.5M | 5.8M | $27.9M | 5.8M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #27 | $27.8M | 5.7M | $28.9M | 6.0M | -341,240-5.64% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.22% | 0.25% | #7 | $21.4M | 4.4M | $21.0M | 4.4M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #42 | $12.8M | 2.6M | $11.3M | 2.4M | +261,966+11.08% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #21 | $12.2M | 2.5M | $12.4M | 2.6M | -112,404-4.32% | Reduce |
| Euclidean Capital LLC |
| 1.75% | 1.92% | #2 | $7.7M | 1.6M | $7.5M | 1.6M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $7.3M | 1.5M | $7.1M | 1.5M | -478-0.03% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $4.4M | 910,866 | $4.1M | 848,172 | +62,694+7.39% | Add |
| Siren, L.L.C. |
| 0.07% | 0.1% | #10 | $3.5M | 720,720 | $3.4M | 720,720 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #50 | $3.4M | 697,469 | $3.2M | 679,787 | +17,682+2.60% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #34 | $2.7M | 558,685 | $2.1M | 448,976 | +109,709+24.44% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #25 | $1.8M | 377,936 | $1.9M | 406,425 | -28,489-7.01% | Reduce |
| Candriam S.C.A. |
| 0.01% | — | #18 | $1.5M | 313,765 | $0 | 0 | +313,765 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #43 | $1.5M | 309,775 | $1.3M | 275,875 | +33,900+12.29% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | 0.01% | #19 | $1.5M | 305,434 | $1.5M | 303,757 | +1,677+0.55% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $1.5M | 304,432 | $1.2M | 255,931 | +48,501+18.95% | Add |
| Birchview Capital, LP |
| 0.62% | 0.77% | #4 | $1.4M | 281,937 | $1.3M | 281,730 | +207+0.07% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #38 | $1.3M | 264,422 | $1.2M | 240,586 | +23,836+9.91% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #29 | $992,084 | 203,296 | $388,509 | 81,278 | +122,018+150.12% | Add |
| Woodline Partners LP |
| <0.01% | <0.01% | #22 | $986,468 | 202,145 | $861,992 | 180,333 | +21,812+12.10% | Add |
| B Group, Inc. |
| 0.46% | 0.36% | #5 | $976,000 | 200,000 | $487,560 | 102,000 | +98,000+96.08% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #24 | $855,981 | 175,406 | $550,001 | 115,063 | +60,343+52.44% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $801,569 | 164,256 | $650,596 | 136,108 | +28,148+20.68% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #52 | $775,051 | 158,822 | $956,062 | 200,013 | -41,191-20.59% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #30 | $636,088 | 130,346 | $495,892 | 103,743 | +26,603+25.64% | Add |
| DAFNA Capital Management LLC |
| 0.1% | 0.12% | #8 | $545,872 | 111,859 | $534,686 | 111,859 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $535,731 | 109,781 | $494,850 | 103,525 | +6,256+6.04% | Add |
| SCS Capital Management LLC |
| <0.01% | 0.01% | #20 | $522,062 | 106,980 | $511,364 | 106,980 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $449,429 | 92,096 | $311,376 | 63,676 | +28,420+44.63% | Add |
| Palumbo Wealth Management LLC |
| 0.09% | — | #9 | $447,687 | 91,739 | $0 | 0 | +91,739 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #17 | $437,248 | 89,600 | $356,588 | 74,600 | +15,000+20.11% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #62 | $387,253 | 79,355 | $380,293 | 79,559 | -204-0.26% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #69 | $381,298 | 78,135 | $84,778 | 17,736 | +60,399+340.54% | Add |
| DIADEMA PARTNERS LP |
| 0.04% | 0.07% | #13 | $326,511 | 66,908 | $382,132 | 79,944 | -13,036-16.31% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $323,247 | 66,239 | $155,636 | 32,560 | +33,679+103.44% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #55 | $317,390 | 65,039 | $240,807 | 50,378 | +14,661+29.10% | Add |
| Lynx1 Capital Management LP |
| 0.06% | — | #12 | $300,549 | 61,588 | $0 | 0 | +61,588 | New Buy |
| STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #33 | $283,499 | 58,094 | $313,783 | 65,645 | -7,551-11.50% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $261,124 | 53,509 | $141,259 | 29,552 | +23,957+81.07% | Add |
| Verdad Advisers, LP |
| 0.25% | 0.13% | #6 | $259,767 | 53,231 | $116,708 | 24,416 | +28,815+118.02% | Add |
| Persistent Asset Partners Ltd |
| 0.07% | 0.08% | #11 | $228,735 | 46,872 | $222,959 | 46,644 | +228+0.49% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.02% | — | #14 | $224,358 | 45,975 | $0 | 0 | +45,975 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #47 | $193,152 | 39,582 | $188,825 | 39,505 | +77+0.19% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $189,266 | 38,784 | $177,000 | 37,631 | +1,153+3.06% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #64 | $178,301 | 36,537 | $131,073 | 27,421 | +9,116+33.24% | Add |
| Jump Financial, LLC |
| <0.01% | <0.01% | #26 | $177,549 | 36,383 | $65,677 | 13,740 | +22,643+164.80% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #73 | $172,268 | 35,301 | $70,462 | 14,741 | +20,560+139.47% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | — | #16 | $143,989 | 29,506 | $0 | 0 | +29,506 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #65 | $142,253 | 29,760 | $143,964 | 26,660 | +3,100+11.63% | Add |
