| RA CAPITAL MANAGEMENT, L.P. |
| 0.23% | 0.28% | #9 | $26.9M | 13.0M | $26.1M | 13.0M | 00.00% | Unchanged |
| venBio Partners LLC |
| 5.14% | 9.21% | #1 | $26.7M | 12.9M | $25.8M | 12.9M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $15.3M | 7.4M | $897,836 | 447,799 | +7.0M+1,552.42% | Add |
| Redmile Group, LLC |
| 1.03% | 1.06% | #6 | $15.3M | 7.4M | $16.0M | 8.0M | -571,684-7.18% | Reduce |
| Blackstone Inc. |
| 0.04% | 0.05% | #16 | $13.6M | 6.6M | $11.7M | 5.8M | +766,999+13.16% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.07% | 0.08% | #12 | $12.5M | 6.0M | $11.5M | 5.7M | +290,620+5.07% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.24% | — | #5 | $11.9M | 5.7M | $0 | 0 | +5.7M | New Buy |
| TCG Crossover Management, LLC |
| 0.28% | 0.75% | #8 | $11.7M | 5.7M | $26.1M | 13.0M | -7.4M-56.54% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $10.3M | 5.0M | $8.4M | 4.2M | +793,700+18.99% | Add |
| Vivo Capital, LLC |
| 0.6% | 0.53% | #7 | $6.6M | 3.2M | $6.4M | 3.2M | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #22 | $6.4M | 3.1M | $7.5M | 3.8M | -685,720-18.25% | Reduce |
| 5AM Venture Management, LLC |
| 2.2% | 1.7% | #3 | $6.3M | 3.1M | $6.1M | 3.1M | 00.00% | Unchanged |
| Almitas Capital LLC |
| 1.42% | 1.44% | #4 | $6.1M | 2.9M | $6.4M | 3.2M | -235,403-7.42% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.11% | 0.11% | #11 | $5.9M | 2.9M | $5.7M | 2.9M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $5.8M | 2.8M | $989,757 | 493,437 | +2.3M+464.98% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #25 | $4.5M | 2.2M | $3.2M | 1.6M | +590,343+37.18% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $3.2M | 1.5M | $4.0M | 2.0M | -444,965-22.38% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #57 | $3.1M | 1.5M | $352,535 | 175,828 | +1.3M+752.48% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $2.7M | 1.3M | $2.2M | 1.1M | +212,465+19.30% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #52 | $2.3M | 1.0M | $189 | 99 | +1.0M+1,055,180.81% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #45 | $1.9M | 935,669 | $274,613 | 136,964 | +798,705+583.15% | Add |
| Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #28 | $1.7M | 810,297 | $1.9M | 950,550 | -140,253-14.75% | Reduce |
| Nantahala Capital Management, LLC |
| 0.05% | — | #14 | $1.6M | 750,000 | $0 | 0 | +750,000 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $1.6M | 749,229 | $196,251 | 97,881 | +651,348+665.45% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #41 | $1.5M | 743,491 | $590,428 | 294,478 | +449,013+152.48% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $1.5M | 742,331 | $277,879 | 138,593 | +603,738+435.62% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $1.2M | 603,797 | $1.5M | 732,599 | -128,802-17.58% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.05% | — | #15 | $1.1M | 533,660 | $0 | 0 | +533,660 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #54 | $958,292 | 462,943 | $1.8M | 914,754 | -451,811-49.39% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| 0.05% | 0.01% | #13 | $856,038 | 413,545 | $138,000 | 68,987 | +344,558+499.45% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #63 | $499,104 | 241,113 | $0 | 0 | +241,113 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #59 | $493,585 | 238,447 | $0 | 0 | +238,447 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #20 | $467,969 | 226,072 | $152,524 | 76,072 | +150,000+197.18% | Add |
| Atom Investors LP |
| 0.04% | — | #17 | $454,121 | 219,382 | $0 | 0 | +219,382 | New Buy |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #31 | $363,041 | 175,382 | $184,927 | 92,233 | +83,149+90.15% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #81 | $326,798 | 157,873 | $156,081 | 85,290 | +72,583+85.10% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #75 | $310,341 | 149,923 | $22,014 | 10,980 | +138,943+1,265.42% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #76 | $306,271 | 147,957 | $2.7M | 1.4M | -1.2M-89.14% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #61 | $297,345 | 143,645 | $0 | 0 | +143,645 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #48 | $223,350 | 107,902 | $0 | 0 | +107,902 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #64 | $222,376 | 107,428 | $0 | 0 | +107,428 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #74 | $206,847 | 99,926 | $0 | 0 | +99,926 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #79 | $185,843 | 89,779 | $0 | 0 | +89,779 | New Buy |
| Verdad Advisers, LP |
| 0.16% | — | #10 | $170,154 | 82,200 | $0 | 0 | +82,200 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #87 | $157,386 | 76,032 | $1.2M | 577,783 | -501,751-86.84% | Reduce |
| Graham Capital Management, L.P. |
| <0.01% | <0.01% | #27 | $154,879 | 74,821 | $75,667 | 37,739 | +37,082+98.26% | Add |
| XTX Topco Ltd |
| <0.01% | <0.01% | #29 | $144,190 | 69,657 | $88,503 | 44,141 | +25,516+57.81% | Add |
| MetLife Investment Management, LLC |
| <0.01% | — | #36 | $134,465 | 64,959 | $0 | 0 | +64,959 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #73 | $104,815 | 50,635 | $34 | 17 | +50,618+297,752.94% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #53 | $102,842 | 49,682 | $0 | 0 | +49,682 | New Buy |
