| Nantahala Capital Management, LLC |
| 1.27% | 1% | #4 | $38.0M | 6.2M | $27.0M | 6.0M | +123,438+2.05% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #68 | $20.7M | 3.4M | $14.3M | 3.2M | +156,944+4.91% | Add |
| AIGH Capital Management LLC |
| 1.16% | 1.89% | #5 | $18.5M | 3.0M | $13.9M | 3.1M | -113,000-3.65% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #69 | $13.7M | 2.2M | $9.7M | 2.2M | +46,582+2.15% | Add |
| Cable Car Capital, LP |
| 4.39% | 4.47% | #1 | $13.5M | 3.0M | $13.5M | 3.0M | 00.00% | Unchanged |
| OneDigital Investment Advisors LLC |
| 0.09% | — | #16 | $10.2M | 1.7M | $0 | 0 | +1.7M | New Buy |
| AWM Investment Company, Inc. |
| 0.8% | 0.4% | #6 | $9.2M | 1.5M | $3.6M | 803,130 | +683,000+85.04% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #61 | $7.8M | 1.3M | $5.4M | 1.2M | +51,293+4.24% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.14% | 0.12% | #13 | $7.7M | 1.2M | $5.7M | 1.3M | -23,440-1.86% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #52 | $7.6M | 1.2M | $5.1M | 1.1M | +94,187+8.33% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #73 | $6.4M | 1.0M | $4.3M | 957,328 | +82,900+8.66% | Add |
| Propel Bio Management, LLC |
| 3.18% | 3.79% | #2 | $6.1M | 983,070 | $6.0M | 1.3M | -346,829-26.08% | Reduce |
| NAN FUNG TRINITY (HK) Ltd |
| 0.58% | 0.47% | #7 | $5.9M | 956,770 | $4.3M | 956,770 | 00.00% | Unchanged |
| Diametric Capital, LP |
| 0.49% | 0.71% | #9 | $4.7M | 755,021 | $2.7M | 611,520 | +143,501+23.47% | Add |
| J. Goldman & Co LP |
| 0.11% | 0.08% | #14 | $4.2M | 678,173 | $2.9M | 640,530 | +37,643+5.88% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.39% | 0.3% | #10 | $3.8M | 610,407 | $2.9M | 648,942 | -38,535-5.94% | Reduce |
| Rubric Capital Management LP |
| 0.03% | — | #23 | $3.8M | 608,771 | $0 | 0 | +608,771 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #70 | $3.7M | 603,377 | $5.0M | 1.1M | -505,293-45.58% | Reduce |
| Stonepine Capital Management, LLC |
| 0.53% | 1.52% | #8 | $3.4M | 557,284 | $3.8M | 846,587 | -289,303-34.17% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #64 | $3.4M | 552,630 | $2.0M | 435,973 | +116,657+26.76% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #45 | $3.4M | 548,300 | $2.3M | 522,445 | +25,855+4.95% | Add |
| NATIONAL BANK OF CANADA /FI/ |
| <0.01% | <0.01% | #42 | $3.1M | 500,000 | $2.2M | 500,000 | 00.00% | Unchanged |
| MONTANOVA CAPITAL, LLC |
| 0.06% | 0.31% | #18 | $3.1M | 500,000 | $12.0M | 2.7M | -2.2M-81.32% | Reduce |
| Knoll Capital Management, LLC |
| 1.72% | 1.15% | #3 | $3.0M | 485,515 | $2.2M | 485,515 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #67 | $2.8M | 454,401 | $1.3M | 288,037 | +166,364+57.76% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #35 | $2.5M | 409,075 | $892,170 | 199,145 | +209,930+105.42% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #78 | $2.3M | 372,406 | $1.8M | 394,274 | -21,868-5.55% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #86 | $2.3M | 365,559 | $3.2M | 607,641 | -242,082-39.84% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #40 | $2.2M | 360,800 | $0 | 0 | +360,800 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #62 | $2.2M | 356,427 | $122,072 | 27,248 | +329,179+1,208.08% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #57 | $2.2M | 348,018 | $1.5M | 339,515 | +8,503+2.50% | Add |
| Simplify Asset Management Inc. |
| 0.03% | 0.03% | #24 | $2.1M | 345,416 | $2.3M | 507,988 | -162,572-32.00% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #93 | $1.8M | 291,653 | $1.2M | 270,976 | +20,677+7.63% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #43 | $1.5M | 245,046 | $939,039 | 209,607 | +35,439+16.91% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #74 | $1.4M | 223,279 | $1.0M | 233,924 | -10,645-4.55% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.01% | — | #33 | $1.3M | 212,325 | $0 | 0 | +212,325 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $1.3M | 211,335 | $1.9M | 425,426 | -214,091-50.32% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #72 | $1.3M | 204,246 | $867,470 | 193,632 | +10,614+5.48% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #46 | $1.2M | 194,827 | $969,047 | 216,305 | -21,478-9.93% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #107 | $855,912 | 138,497 | $872,762 | 194,813 | -56,316-28.91% | Reduce |
| Headlands Technologies LLC |
| 0.08% | 0.03% | #17 | $773,056 | 125,090 | $283,786 | 63,345 | +61,745+97.47% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #87 | $744,777 | 120,514 | $569,448 | 127,109 | -6,595-5.19% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #98 | $673,620 | 109,000 | $636,608 | 142,100 | -33,100-23.29% | Reduce |
| Palo Alto Investors LP |
| 0.1% | 0.07% | #15 | $672,786 | 108,865 | $487,715 | 108,865 | 00.00% | Unchanged |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #55 | $652,361 | 105,560 | $772,621 | 172,460 | -66,900-38.79% | Reduce |
| Gem Investment Advisors, LLC |
| 0.38% | — | #11 | $612,339 | 99,084 | $0 | 0 | +99,084 | New Buy |
| Corient Private Wealth LLC |
| <0.01% | — | #60 | $555,632 | 89,908 | $0 | 0 | +89,908 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #85 | $510,628 | 82,626 | $254,101 | 56,719 | +25,907+45.68% | Add |
| Pale Fire Capital SE |
| 0.04% | 0.03% | #22 | $506,420 | 81,945 | $312,906 | 69,845 | +12,100+17.32% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #66 | $498,955 | 80,737 | $0 | 0 | +80,737 | New Buy |
