| FMR LLC |
| 0.07% | 0.11% | #147 | $1.72B | 16.1M | $2.15B | 13.2M | +3.0M+22.67% | Add |
| BlackRock, Inc. |
| 0.02% | 0.05% | #262 | $1.69B | 15.8M | $2.73B | 16.7M | -870,162-5.22% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.05% | 0.09% | #185 | $1.11B | 10.4M | $1.70B | 10.4M | +36,160+0.35% | Add |
| JPMORGAN CHASE & CO |
| 0.06% | 0.24% | #168 | $1.09B | 10.4M | $3.70B | 24.2M | -13.7M-56.82% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.02% | 0.04% | #276 | $1.04B | 9.8M | $1.58B | 9.6M | +148,734+1.54% | Add |
| BAKER BROS. ADVISORS LP |
| 4.7% | 6.97% | #10 | $937.8M | 8.8M | $1.21B | 7.4M | +1.4M+18.53% | Add |
| Capital International Investors |
| 0.18% | 0.21% | #104 | $878.3M | 8.2M | $914.9M | 5.6M | +2.6M+47.24% | Add |
| Darwin Global Management, Ltd. |
| 17.91% | 68.33% | #1 | $673.6M | 6.4M | $2.58B | 16.8M | -10.4M-61.73% | Reduce |
| AMERIPRISE FINANCIAL INC |
| 0.13% | 0.12% | #116 | $658.9M | 6.2M | $500.0M | 3.1M | +3.1M+102.10% | Add |
| Orbis Allan Gray Ltd |
| 2.23% | 1.29% | #21 | $647.9M | 6.1M | $306.2M | 1.9M | +4.2M+224.46% | Add |
| STATE STREET CORP |
| 0.02% | 0.03% | #294 | $645.3M | 6.1M | $907.8M | 5.6M | +500,475+9.01% | Add |
| D. E. Shaw & Co., Inc. |
| 0.3% | 0.55% | #81 | $633.1M | 5.9M | $922.7M | 5.6M | +295,334+5.23% | Add |
| Artisan Partners Limited Partnership |
| 0.92% | 1.71% | #38 | $580.2M | 5.4M | $1.07B | 6.5M | -1.1M-16.63% | Reduce |
| RTW INVESTMENTS, LP |
| 4.41% | 7.88% | #11 | $516.3M | 4.8M | $791.9M | 4.8M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.05% | #266 | $448.8M | 4.2M | $733.3M | 4.5M | -230,234-5.17% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | 0.06% | #217 | $363.1M | 3.4M | $505.7M | 3.1M | +312,483+10.10% | Add |
| NORGES BANK |
| 0.04% | 0.02% | #218 | $360.1M | 3.4M | $133.0M | 1.7M | +1.6M+93.80% | Add |
| CITADEL ADVISORS LLC |
| 0.04% | 0.07% | #207 | $339.9M | 3.2M | $427.3M | 2.6M | +574,802+22.00% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.11% | 0.09% | #128 | $312.2M | 2.9M | $211.8M | 1.3M | +1.6M+126.10% | Add |
| Duquesne Family Office LLC |
| 5.68% | 5.59% | #8 | $295.8M | 2.8M | $188.7M | 1.2M | +1.6M+140.42% | Add |
| Jupiter Topco LLC |
| 0.11% | — | #124 | $277.8M | 2.6M | $0 | 0 | +2.6M | New Buy |
| UBS Group AG |
| 0.04% | 0.04% | #220 | $275.8M | 2.6M | $284.1M | 1.7M | +848,981+48.86% | Add |
| FRANKLIN RESOURCES INC |
| 0.05% | 0.09% | #187 | $242.4M | 2.3M | $428.0M | 2.6M | -344,029-13.14% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.02% | 0.02% | #288 | $241.1M | 2.3M | $154.1M | 942,646 | +1.3M+139.92% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.02% | #305 | $230.7M | 2.2M | $176.4M | 1.1M | +1.1M+100.57% | Add |
| MAVERICK CAPITAL LTD |
| 2.03% | — | #22 | $229.3M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Qube Research & Technologies Ltd |
| 0.17% | 0.03% | #107 | $179.4M | 1.7M | $24.3M | 148,515 | +1.5M+1,032.77% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.57% | 1.01% | #56 | $173.7M | 1.6M | $240.1M | 1.5M | +161,102+10.97% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.11% | — | #123 | $173.0M | 1.6M | $0 | 0 | +1.6M | New Buy |
| Caption Management, LLC |
| 0.8% | 0.14% | #45 | $171.3M | 1.6M | $23.5M | 143,500 | +1.5M+1,019.65% | Add |
| Integral Health Asset Management, LLC |
| 6.74% | 11.73% | #6 | $170.6M | 1.6M | $245.3M | 1.5M | +100,000+6.67% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.03% | 0.06% | #228 | $149.4M | 1.4M | $221.5M | 1.4M | +47,036+3.47% | Add |
| Bellevue Group AG |
| 3.13% | 0.04% | #16 | $148.6M | 1.4M | $1.6M | 10,034 | +1.4M+13,786.96% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.18% | 0.05% | #105 | $143.2M | 1.3M | $38.0M | 232,607 | +1.1M+477.42% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.03% | 0.04% | #255 | $142.3M | 1.3M | $198.7M | 1.2M | +120,046+9.88% | Add |
| Paradigm Biocapital Advisors LP |
| 2.65% | 4.19% | #19 | $141.4M | 1.3M | $205.1M | 1.3M | +71,489+5.70% | Add |
| NORTHERN TRUST CORP |
| 0.02% | 0.03% | #316 | $140.2M | 1.3M | $211.6M | 1.3M | +21,325+1.65% | Add |
| Bank of New York Mellon Corp |
| 0.02% | 0.04% | #269 | $140.0M | 1.3M | $206.5M | 1.3M | +50,007+3.96% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.1% | 0.03% | #132 | $133.3M | 1.3M | $38.8M | 237,017 | +1.0M+427.48% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #391 | $131.5M | 1.2M | $138.8M | 963,631 | +269,867+28.01% | Add |
| Pictet Asset Management Holding SA |
| 0.12% | 0.19% | #118 | $129.8M | 1.2M | $178.7M | 1.1M | +118,105+10.71% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.03% | #309 | $129.4M | 1.2M | $174.9M | 1.1M | +144,573+13.52% | Add |
| Hood River Capital Management LLC |
| 0.82% | 1.13% | #43 | $112.7M | 1.1M | $112.6M | 688,554 | +368,317+53.49% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.02% | #390 | $109.1M | 1.0M | $245.7M | 1.5M | -479,167-31.90% | Reduce |
| SEI INVESTMENTS CO |
| 0.09% | 0.21% | #134 | $108.3M | 1.0M | $228.2M | 1.4M | -379,924-27.22% | Reduce |
| NWI MANAGEMENT LP |
| 5% | 7.96% | #9 | $108.1M | 1.0M | $172.0M | 988,460 | +25,540+2.58% | Add |
| Castle Hook Partners LP |
| 0.49% | 4.18% | #64 | $105.9M | 993,310 | $207.6M | 1.3M | -276,444-21.77% | Reduce |
| JANE STREET GROUP, LLC |
| 0.01% | 0.01% | #365 | $105.8M | 992,028 | $74.5M | 455,601 | +536,427+117.74% | Add |
| JENNISON ASSOCIATES LLC |
| 0.06% | 0.07% | #170 | $96.5M | 905,094 | $98.9M | 604,694 | +300,400+49.68% | Add |
| Polar Capital Holdings Plc |
| 0.22% | 0.21% | #93 | $95.0M | 890,872 | $60.2M | 368,107 | +522,765+142.01% | Add |
